Key Words HIV infection
Ketotifen; nutritional status
Tumor Necrosis Factor alpha
Tumor Necrosis Factor Receptors
Springer Online Journal Archives 1860-2000
Chemistry and Pharmacology
Abstract Objective: Tumor necrosis factor alpha (TNF-α) is involved in the genesis of HIV-associated malnutrition. We performed an open-label trial on the effects of ketotifen, an in vitro inhibitor of TNF-α release from peripheral blood mononuclear cells (PBMCs), on the nutritional status and TNF-α release of HIV-infected subjects. Patients: Six HIV-infected subjects received oral ketotifen 4 mg per day for 84 days and were followed up for an additional 70-day period. Body composition was measured by bioelectrical impedance analysis. TNF-α plasma levels, TNF-α release from PBMCs, and plasma concentration of soluble TNF receptors were measured repeatedly during the study and control period. Results: During ketotifen intake, TNF-α release from stimulated PBMCs significantly decreased (68 vs 155 pg ml−1), but not TNF-α and soluble TNF receptor plasma concentrations. Subjects gained weight (+ 2.7 kg), whereas weight loss was observed after cessation of treatment (−1.6 kg). Conclusion: Ketotifen inhibits TNF-α release from stimulated PBMCs and might thus be useful in the management of HIV-associated malnutrition.
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