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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  80. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20090520-20090524; Rostock; DOC09hnod334 /20090417/
    Publication Date: 2009-04-25
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20091021-20091024; Berlin; DOCWI60-1338 /20091015/
    Publication Date: 2009-10-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  44. gemeinsamen Tagung der Bayerischen Urologenvereinigung und der Österreichischen Gesellschaft für Urologie und Andrologie; 20180614-20180616; Rosenheim; DOC18urobay086 /20180517/
    Publication Date: 2018-05-18
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    Keywords: Germany ; MODEL ; PERFUSION ; PHASE-I ; IMAGES ; imaging ; QUANTIFICATION ; HEPATOCELLULAR-CARCINOMA ; liver ; BLOOD-FLOW ; MICROCIRCULATION ; REPERFUSION ; TRANSPLANTATION ; CONTRAST ; CONTRAST AGENT ; MR ; SEQUENCE ; SEQUENCES ; magnetic resonance ; MAGNETIC-RESONANCE ; magnetic resonance imaging ; DISPLAY ; MORPHOLOGY ; HEAD ; ISCHEMIA ; dynamic MRI ; HEPATIC PERFUSION ; development ; PHASE ; COIL ; Phase I ; CIRCULATION ; MEDICINE ; MEDIA ; RESONANCE ; German ; PHARMACOKINETIC ANALYSIS ; CONTRAST-MEDIA ; SCANNER ; isolated organs
    Abstract: The investigation of reperfusion of organs after an ischaemic phase is of great interest in transplantation medicine. This work presents an experimental organ model for the examination of isolated canine livers by means of magnetic resonance imaging in reperfusion experiments. The perfusion of the organs inside a perfusate container in the scanner's head coil was performed with approximately physiological conditions for 1.5 hours. The pumps for the perfusate circulation were installed outside the scanner's room, where oxygenation and heating of the perfusate was also performed. In the MR examinations, T1- and T2-weighted sequences could be used to display the morphology of the organs and the spatial perfusion distribution after administration of contrast media. The images revealed oedema development during reperfusion and an inhomogenous perfusion distribution. Thus, the model allows for the non-invasive investigation of morphology and perfusion distribution in isolated reperfused organs
    Type of Publication: Journal article published
    PubMed ID: 17879818
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  • 5
    Keywords: IN-VIVO ; SYSTEM ; magnetic resonance ; virus ; monitoring
    Type of Publication: Journal article published
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  59. Jahrestagung der Südwestdeutschen Gesellschaft für Urologie e.V. - Urologie im Südwesten: Innovation aus Tradition; 20180606-20180609; Offenburg; DOC18swdgu031 /20180605/
    Publication Date: 2018-06-05
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 7
    ISSN: 1435-1803
    Keywords: Key words Torsades de Pointes – guinea pig hearts – veratridine – DPI 201-106 – Magnesium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Torsades de Pointes (TdP) is a polymorphic ventricular arrhythmia which can degenerate into ventricular fibrillation. The most typical symptom of TdP is the ECG morphology where QRS complexes seem to rotate around the isoelectric baseline. Bradycardia and delayed repolarization are regarded as pathophysiologic predispositions. For better understanding of the pathophysiology and the evaluation of therapeutic or proarrhythmic potential of drugs, a functional experimental model is needed. In the present study, an experimental model of polymorphic tachyarrhythmias taken as TdP equivalents in isolated guinea pig hearts was developed. The hearts were perfused by the Langendorff technique. Bradycardia was induced by dissection of the sinus node, and prolongation of the QT interval by infusion of two inhibitors of the sodium channel inactivation, veratridine and DPI 201-106. TdP equivalents were triggered reproducibly by application of electrical single stimuli at the end of the T wave. Experiments with different concentrations of the channel active substances alone and in combination, with different perfusion times and mode of electrical stimulation (single pulse versus train stimulation), showed the highest incidence for TdP equivalents by means of an initial 30 min long infusion of 0.5 μM each veratridine and DPI 201-106 in combination with electrical single stimuli. After finishing the infusion with the channel active substances but still with lasting effects from them, TdP equivalents were triggered repeatedly in five of six experiments. The reasons for this increased TdP susceptibility after finishing the infusion are not known. In a separate series of six similarly arranged experiments, the incidence for TdP equivalents could be decreased from 83% to 12.5% (p〈0.001) by increasing the concentration of magnesiumm in the perfusate from 1.17 to 5.0 mM. With these experiments, the clinically known therapeutic effect of magnesium suppressing TdP could be demonstrated in an in vitro model for the first time. The results suggest that this model could be used as a base for further studies of clinical relevant drugs, especially antiarrhythmic agents, to obtain hints of possible risks of proarrhythmic effects or of suitability for therapeutic use at TdP attacks.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1435-4373
    Keywords: Pneumonia ; Bronchoalveolar lavage ; Diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The bacterial index (BI) as defined by the sum of log10 colony-forming units (cfu) of microorganisms per milliliter of bronchoalveolar lavage (BAL) fluid, i.e., a multiplication of the single cfu/ml, has been used to distinguish between polymicrobial pneumonia (BI≥5) and colonization (BI〈5). Since many false-positive results are to be expected using this parameter, the diagnostic value of the BI was studied prospectively by obtaining bacteriologic cultures of BAL fluid in 165 consecutive unselected patients. In 27 cases the diagnosis of bacterial pneumonia was established on clinical criteria. In 133 patients pneumonia could be excluded, and in five patients the diagnosis remained unclear. Using a cut-off of ≥105 cfu/ml BAL fluid, sensitivity and specificity for the diagnosis of pneumonia were 33% (9/27) and 99% (132/133), respectively. Sensitivity was mainly influenced by prior treatment with antibiotics, being 70% (7/10) in untreated and 12% (2/17) in treated patients. Applying the BI methodology at a cut-off of ≥ 5, however, resulted in an unacceptably high rate of 16 additional false-positive results, thus lowering the specificity to 87% (116/133;P〈0.0001) while increasing the sensitivity to only 41% (11/27;P=0.77). In conclusion, given the high rate of false-positive results, the methodology of the BI is of doubtful value for the diagnosis of bacterial pneumonia by BAL in an unselected patient group. By applying the absolute number of cfu/ml BAL fluid, however, positive bacteriologic cultures of BAL fluid are highly specific for the diagnosis of pneumonia. Their sensitivity is limited by previous antibiotic therapy.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1435-4373
    Keywords: Key words Pneumonia ; Bronchoalveolar lavage ; Diagnosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The bacterial index (BI) as defined by the sum of log10 colony-forming units (cfu) of microorganisms per milliliter of bronchoalveolar lavage (BAL) fluid, i.e., a multiplication of the single cfu/ml, has been used to distinguish between polymicrobial pneumonia (BI≥5) and colonization (BI〈5). Since many false-positive results are to be expected using this parameter, the diagnostic value of the BI was studied prospectively by obtaining bacteriologic cultures of BAL fluid in 165 consecutive unselected patients. In 27 cases the diagnosis of bacterial pneumonia was established on clinical criteria. In 133 patients pneumonia could be excluded, and in five patients the diagnosis remained unclear. Using a cut-off of ≥105 cfu/ml BAL fluid, sensitivity and specificity for the diagnosis of pneumonia were 33% (9/27) and 99% (132/133), respectively. Sensitivity was mainly influenced by prior treatment with antibiotics, being 70% (7/10) in untreated and 12% (2/17) in treated patients. Applying the BI methodology at a cut-off of ≥5, however, resulted in an unacceptably high rate of 16 additional false-positive results, thus lowering the specificity to 87% (116/133;P〈0.0001) while increasing the sensitivity to only 41% (11/27;P=0.77). In conclusion, given the high rate of false-positive results, the methodology of the BI is of doubtful value for the diagnosis of bacterial pneumonia by BAL in an unselected patient group. By applying the absolute number of cfu/ml BAL fluid, however, positive bacteriologic cultures of BAL fluid are highly specific for the diagnosis of pneumonia. Their sensitivity is limited by previous antibiotic therapy.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1435-1803
    Keywords: Potassium channel openers ; monophasic action potentials ; refractory period ; dofetilide ; calcium currents ; guinea pig ventricular myocytes ; whole cell patch clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the potassium channel openers (KCO), cromakalim or pinacidil, were evaluated in an anesthetized porcine model of pacing- and ischemia-induced ventricular fibrillation (VF). Hearts were paced at 180 bpm and the left anterior descending coronary artery was occluded until VF was induced. Reproducible times to VF (in seconds) were obtained allowing at least 20 min recovery following defibrillation. Cromakalim (0.3 mg/kg) or pinacidil (3 mg/kg) produced equivalent drops in mean arterial blood pressure. At these doses, cromakalim reduced monophasic action potential duration measured at 90% repolarization (APD90). Although time to VF in the cromakalim group was significantly greater than the vehicle treated group, it was not significantly different from its predrug value. In contrast, pinacidil reduced APD90, and significantly increased time to VF from 134±5 to 322±62 s (p〈0.05). Neither cromakalim nor pinacidil affected whole-cell calcium currents recorded in guinea pig myocytes. During ischemia, cromakalim or pinacidil further reduced APD90; however, pinacidil had a two-fold greater effect than did cromakalim. The Class III antiarrhythmic agent, dofetilide, prolonged APD90, but did not increase time to VF. In conclusion, the increased time to VF observed with pinacidil coincides with its ability to shorten APD, and is consistent with activation of ATP-sensitive K+ channels (K+ ATP). It is suggested that indirect reduction of calcium influx through K+ ATP activation and APD shortening is sufficient to increase time to VF in this model. However, the inability of dofetilide to be effective suggests that this model would not be useful to test for Class III antiarrhythmic agents.
    Type of Medium: Electronic Resource
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