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  • 1
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  36. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2018); 20180110-20180113; Garmisch-Partenkirchen; DOCV 54 /20180109/
    Publication Date: 2018-01-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Abstract: Telomere shortening is of pathogenic and prognostic importance in cancers. In the present study, we analyzed telomere length in 73 mantle cell lymphoma (MCL), 55 chronic lymphocytic leukemia (CLL), and 20 normal B-cell samples using quantitative PCR (Q-PCR) to study its association with disease characteristics and outcome. Telomere length was found to be highly variable in MCL (range, 2.2-13.8 kb; median, 4.3 kb). Telomere dysfunction in MCL was evident from comparison with normal B cells (median, 7.5 kb), but had no significant association with any biologic or clinical feature. This was in contrast to CLL, in which a significant correlation of short telomeres with poor prognostic subgroups was confirmed. There was a trend toward an increased number of genomic aberrations with shortening of telomeres in MCL. No difference in survival was observed between the groups with short and long telomeres, indicating that, as opposed to CLL, telomere length is not of prognostic relevance in MCL.
    Type of Publication: Journal article published
    PubMed ID: 23243283
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  • 3
    Keywords: INHIBITOR ; Germany ; PATHWAY ; SUPPORT ; DRUG ; PATIENT ; COMPLEX ; COMPLEXES ; DNA ; DOWN-REGULATION ; treatment ; DELETION ; resistance ; MUTATION ; chemotherapy ; leukemia ; p53 ; DAMAGE ; DNA-DAMAGE ; TP53 ; INHIBITORS ; review ; CLL ; DEFECTS ; DNA damage ; ATM ; CHALLENGES ; PROPORTION ; TP53 mutation ; 17p deletion
    Abstract: The importance of studying p53 pathway defects in chronic lymphocytic leukemia (CLL) has been promoted by the demonstration of the fundamentally different clinical course of patients with 17p deletion. The observation of resistance to chemotherapy and mutation of the remaining TP53 allele explain the clinical presentation of CLL with 17p deletion. Here we review recent evidence that cases with TP53 mutation in the absence of the deletion of 17p have a similar clinical and biological course as cases carrying the deletion 17p. In addition, other principal components of the DNA damage pathway reportedly are de-regulated by mutation (ATM), deletion (ATM) or potentially more complex down-regulation (miR-34a) in CLL. Nonetheless, challenges remain because we can only explain resistance in a proportion of the cases that are resistant to first line treatment. This is of particular practical interest because our armamentarium of drugs in clinical use that acts independent of the DNA damage pathway is growing, for example antibody-based treatment (alemtuzumab), immuno-modulating drugs (lenalidomide), CDK inhibitors (flavopiridol) and steroids.
    Type of Publication: Journal article published
    PubMed ID: 19347737
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  • 4
    Abstract: The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are currently unknown. We performed a large mutation analysis of TP53 at four centers and characterized the pattern of TP53 mutations in CLL. We report on 268 mutations in 254 patients with CLL. Missense mutations appeared in 74% of cases compared with deletions and insertions (20%), nonsense (4%) and splice site (2%) mutations. The majority (243 of 268) of mutations were located in the DNA-binding domain. Transitions were found in 131 of 268 mutations, with only 41 occurring at methylated CpG sites (15%), suggesting that transitions at CpGs are uncommon. The codons most frequently mutated were at positions 175, 179, 248 and 273; in addition, we detected a common 2-nt deletion in the codon 209. Most mutations (199 of 259) were accompanied by deletion of the other allele (17p-). Interestingly, trisomy 12 (without 17p-) was only found in one of 60 cases with TP53 mutation (without 17p-) compared with 60 of 16 in the cohort without mutation (P=0.006). The mutational profile was not different in the cohorts with and without previous therapy, suggesting that the mechanism underlying the development of mutations may be similar, independent of treatment.Leukemia advance online publication, 23 September 2010; doi:10.1038/leu.2010.208.
    Type of Publication: Journal article published
    PubMed ID: 20861914
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  • 5
    facet.materialart.
    facet.materialart.
    German Medical Science GMS Publishing House; Düsseldorf
    In:  34. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2016); 20160113-20160116; Berchtesgaden, Deutschland; DOC16dav69 /20160112/
    Publication Date: 2016-01-13
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 3556-3560 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We describe the design and performance of a low-cost, bidirectional temperature control system with very high stability and low thermal gradients in a working range from −10 to 70 °C. System elements such as thermal insulation, thermal pumps, and feedback control as well as safety features are discussed. The performance of the entire system under realistic experimental conditions is documented. Precise temperature control has led to significantly improved instrumental stability. An extension of the instrumental window towards slower measurements has been made possible. This temperature-control system is presented in the framework of the extended surface forces apparatus but is also applicable to other scientific instruments that require subnanometer positioning stability over extended periods of time. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 3566-3568 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Nanometer size indentations on polypropylene and polymethylmethacrylate were made with the atomic force microscope and were 200-nm wide and 20-nm deep for a tip penetration depth of 75 nm. To image the indentations with the same tip used for writing, the tip was retracted at high speed, thus detaching any polymer sticking on it. Nanomechanical properties of polymer are studied in the limit of shallow indentations and slow penetration speed. From the hysteresis of the force versus tip motion curve, the dissipated energy during the indentation and the inelastic deformation of the polymer surface can be measured. We find that the measured dissipated energy is proportional to the volume of the indentation times the activation energy needed to excite chain segments motion during the deformation.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 1255-1261 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Scanning probe microscopy was used to investigate electrical microcontacts in the nanometer range. With the atomic force microscope current flowing through the contact as well as current-voltage characteristics of the contact as a function of the force acting on the contact itself were recorded. With the scanning tunneling microscope current-voltage characteristics and voltage at constant current characteristics were measured as a function of the contact position. From these experiments we conclude that a TiB2 microcontact can sustain a maximum voltage of about 0.1–1 V before melting. These results were confirmed by a theoretical model. The implications for the functioning of so-called positive temperature coefficient current limiting devices based on filled polymers is discussed. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 67 (2002), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The tribological properties of a chocolate-lubricated tribo-system have been measured with a pin-on-disk tribometer employing poly(tetrafluoroethylene) (PTFE)/zirconia (ZrO2) as the tribo-pair. For this study, a series of test chocolate samples was prepared by systematic variation of conching type, particle-size distribution, milk fat/cocoa butter ratio, and lecithin content. Tribological measurements were found to be sensitive to lecithin content for all particle sizes investigated, while only being sensitive to particle size at high lecithin content. Rheological measurements were found to be sensitive to lecithin content in the case of small particle size, and sensitive to particle size in the case of low lecithin content.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 1700-1707 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: This article describes details of the operation and performance of fast spectral correlation interferometry, which allows for considerably improved operation of the surface forces apparatus. Up to 150 interference fringes can be simultaneously tracked over a wide spectral range, leading to considerably more precise and simultaneous extraction of multiple optical quantities, over a greatly extended distance range. When used for surface-separation measurement, a precision of 25 pm is readily achievable over a distance ranging from 0 to 〉10 μm. Data acquisition rates are also considerably improved, allowing for dynamic measurements. Automated actuation of optical deflectors introduces a multidimensional scanning capability to the optical probe with a lateral resolution of 1 μm. The entire process is computer controlled and features unattended batch processing of complex measurements. This publication illustrates experimental setup, methodology, measurements, and detailed error calculation for a selection of practically relevant situations in the extended surface forces apparatus. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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