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  • 1
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    Chapel Hill : University of North Carolina Press
    Keywords: Federal Writers' Project, History. ; United States, Civilization, 1918-1945. ; United States, Historiography. ; United States, Intellectual life, 20th century. ; National characteristics, American.
    Pages: xii, 293 p.
    ISBN: 0-8078-6166-9
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  • 2
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    Heidelberg
    Call number: YY Diss Hirs/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 39 p.
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  • 3
    Call number: SF77:78 ; ATV-VET:81
    Keywords: Mice / Cytology ; Histology / Atlases ; Animals, Laboratory / Anatomy and histology ; Mice / anatomy and histology
    Notes: Includes index.
    Pages: ix, 151 p. : col. ill.
    ISBN: 0306406861
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  • 4
    Keywords: Medicine ; Emergency Medicine ; Radiology, Medical ; Cardiology ; Neurology ; Neurosurgery ; Medicine & Public Health ; Imaging / Radiology ; Neuroradiology ; Neurology ; Cardiology ; Emergency Medicine ; Neurosurgery ; Springer eBooks
    Pages: : digital
    ISBN: 9783642127519
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  • 5
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    Heidelberg : Springer
    Call number: 08-Inf
    Keywords: Central Nervous System / anatomy & histology ; Brain / anatomy & histology
    Pages: 1 CD-ROM + 1 user's guide (30 p.)
    Edition: Basisversion
    ISBN: 3-540-14643-1
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  • 6
    Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
    Description / Table of Contents: 1. Gene Editing: Double-Strand Break Induced Gene Targeting and Mutagenesis 20 Years Later -- 2. The Development and Use of Zinc-Finger Nucleases -- 3.The Use and Development of TAL Effector Nucleases -- 4. Genome Editing for Neuromuscular Diseases -- 5. Phage Integrases for Genome Editing -- 6. Precise Genome Modification Using Triplex Forming Oligonucleotides and Peptide Nucleic Acids -- 7. Genome Editing by Aptamer-Guided Gene Targeting -- 8. Stimulation of AAV Gene Editing via DSB Repair -- 9. Engineered Nucleases and Trinucleotide Repeat Diseases -- 10. Using Engineered Nucleases to Create HIV-Resistant Cells -- 11. Strategies to Determine Off-Target Effects of Engineered Nucleases
    Abstract: This comprehensive volume explores human genetic engineering its pre-clinical and clinical applications, current developments, and as treatment for hereditary diseases. It presents and evaluates the most recent advances in the understanding of mammalian host DNA repair mechanisms, such as double-strand break induced gene targeting and mutagenesis, the development of zinc-finger nucleases, genome editing for neuromuscular diseases, phase integrases, triplex forming oligonucleotides and peptide nucleic acids, aptamer-guided gene targeting, AAV gene editing via DSB repair, engineered nucleases and trinucleotide repeat diseases, and creation of HIV-resistant cells. The expertly authored chapters contextualize current developments within the history of genome editing while also discussing the current and potential safety concerns of this rapidly growing field. Genome Editing: The Next Step in Gene Therapy, the latest volume in the American Society of Gene and Cell Therapy series, deftly illuminates the potential of genetic engineering technology to eradicate today’s deadliest and most prolific diseases. It is ideal reading for clinicians and researchers in genetics and immunology
    Pages: XVI, 263 p. 48 illus., 5 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9781493935093
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  • 7
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    Stuttgart : Enke
    Call number: WB700:12(2)/1/Mag ; WB700:12(2)/2/Mag ; WB700:12(2)/3/Mag
    Description / Table of Contents: 1. Abth. Die allgemeinen acuten Infectionskrankheiten.--2. Abth. Die chronischen Infections- und Intoxications-Krankheiten, parasitäre Krankheiten, infectiöse Wundkrankheiten und chronische Ernährungs-Anomalieen.--3. Abth. Die Organkrankheiten
    Pages: 3 v.
    Edition: 2. vollständig neue Bearbeitung.
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  • 8
    Call number: 09-MA:448
    Keywords: Differential equations ; Algebras, Linear
    Pages: xi, 358 p. : ill.
    ISBN: 0123495504
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  • 9
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  84. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20130508-20130512; Nürnberg; DOC13hnod090 /20130415/
    Publication Date: 2013-04-16
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 10
    ISSN: 1433-0350
    Keywords: Subdural hematoma ; Epidural hematoma ; Shunt complications ; Hydrocephalus ; CSF overdrainage ; Siphon effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nineteen pericerebral collections (18 subdural and 1 epidural) occurred in a series of 682 consecutive initial shunt insertions for hydrocephalus in children, performed between 1976 and 1984. No collections were observed in 358 reoperations performed in the same patients during the same period. The incidence rate of this complication is nearly four times higher after 2 years of age than in younger children (6.5% versus 1.7%). The rate is also higher, regardless of age, in noncommunicating than in communicating hydrocephalus. Pericerebral collections are observed with high- as well as low-closing pressure valves. Pericerebral collections after shunting were diagnosed in 80% of the cases less than 2 months after surgery. They were asymptomatic in nearly 60% of the cases but could become symptomatic later when they were not treated. At the onset at least, these pericerebral collections are compensated by the outflow of an equal quantity of intraventricular CSF so that ICP is only moderately elevated. Postshunt pericerebral collections may be the consequence of CSF loss at the time of surgery. In most cases, however, they are due to a CSF overdrainage by the valve. This overdrainage, together with the reversal of CSF flow in the highly resistant CSF pathways of hydrocephalus, establishes a pressure lower in the ventricles than in the subarachnoid space and tends to open up the subdural space. The treatment of postshunt subdural collections is the insertion of a simple tubing without valve between the subdural space and the peritoneum, the ventriculoperitoneal shunt being left in place. With this treatment, more than 80% of the collections disappeared or were improved. No complications or secondary aggravation were observed in any of these patients.
    Type of Medium: Electronic Resource
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