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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  43. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20120913-20120915; Bremen; DOCFTIIP11 /20120910/
    Publication Date: 2012-09-11
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  43. Jahrestagung der Deutschen Gesellschaft der Plastischen, Rekonstruktiven und Ästhetischen Chirurgen (DGPRÄC), 17. Jahrestagung der Vereinigung der Deutschen Ästhetisch-Plastischen Chirurgen (VDÄPC); 20120913-20120915; Bremen; DOCFV101 /20120910/
    Publication Date: 2012-09-11
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  68. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 7. Joint Meeting mit der Society of British Neurological Surgeons (SBNS); 20170514-20170517; Magdeburg; DOCMi.13.06 /20170609/
    Publication Date: 2017-06-09
    Keywords: ddc: 610
    Language: English
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  • 4
    ISSN: 1432-1440
    Keywords: Essential hypertension ; Beta-blockade ; Blood volume ; Renin ; Catecholamines ; Essentielle Hypertonie ; Betablokkade ; Blutvolumen ; Renin ; Katecholaminexkretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Untersuchungen bei 55 Patienten mit benigner essentieller Hypertonie zeigten die Betablocker Bufuralol (22 Patienten) und Propranolol (33 Patienten) trotz unterschiedlicher Eigenschaften bezüglich intrinsischer sympathomimetischer Aktivität bei einem Dosisverhältnis von 1:4 dieselbe antihypertensive Wirksamkeit. Eine Normalisierung des Blutdrucks fand sich unter Betablocker-Monotherapie in einem Viertel der Fälle. Körpergewicht und Plasma- und Blutvolumen blieben während vier- bis sechswöchiger Behandlung mit Bufuralol oder Propranolol unverändert, die Plasmakaliumkonzentration stieg leicht an. Bufuralol bewirkte eine etwas geringere Hemmung der Plasmareninaktivität (PRA) (−47%) als Propranolol (−69%). Unter beiden Beta-blockern korrelierte die Blutdruckabnahme umgekehrt mit der Kontroll-PRA (p<0,05). Im Gegensatz zu Propranolol fand sich unter Bufuralol keine signifikante Beziehung zwischen Blutdruck- und Reninänderungen. Dagegen korrelierten die Bufuralol-induzierten Druckänderungen mit Änderungen der Noradrenalinexkretion (r=0,41;p<0,05). Patientengruppen mit niedriger, normaler oder hoher Kontroll-PRA zeigten zudem im Mittel ein paralleles Verhalten der Urinkatecholamine. Diese Befunde sind mit dem Konzept vereinbar, daß PRA beim unbehandelten essentiellen Hypertoniker teilweise ein Index der sympathischen Aktivität ist, und daß letztere eine wichtige Determinante für die Blutdrucksenkung bei Betablokkade ist. Der antihypertensive Effekt von Bufuralol scheint renin-unabhängig zu sein und könnte teilweise die Folge einer Abnahme an freiem peripherem Noradrenalin sein.
    Notes: Summary Studies in 55 patients with benign essential hypertension showed that the beta-blockers bufuralol (22 patients) and propranolol (33 patients) at a dose ratio of 1:4, possess comparable antihypertensive efficacy despite different properties regarding intrinsic sympathomimetic activity. Beta-blocker-monotherapy normalized blood pressure (<140/90 mm Hg) in one fourth of the patients. Body weight and plasma and blood volumes remained unchanged during beta-blockade of four to six weeks duration, the mean plasma potassium was slightly increased. The inhibition of plasma renin activity (PRA) was more pronounced with propranolol (−69%) than with bufuralol (−47%). Wirth both beta-blockers decreases in blood pressure correlated inversely with pre-treatment PRA (p<0.05). Propranolol-induced changes in blood pressure correlated also with associated changes in PRA (p<0.005); in contrast, no such relationship was observed with bufuralol. The blood pressure effects of bufuralol, however, correlated significantly with changes in urinary noradrenaline excretion (r=0.41;p<0.05). Patient sub-groups with low, normal or high pre-treatment PRA in the average showed a comparable pattern of pre-treatment noradrenaline excretion and patients with normal renin levels excreted more adrenaline than those with low renin levels (p<0.01). These data are consistent with the concept that in untreated essential hypertension PRA may be an index of adrenergic activity, the latter representing an important determinant of blood pressure response to beta-blockade. The blood pressure lowering effects of bufuralol in benign essential hypertension seem to be independent of renin and may be related, at least partly, to diminished free peripheral noradrenaline levels.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9071
    Keywords: Retinal pigment epithelium ; epithelium ; permeability ; hyperplasia ; pathology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In rats with retinopathies induced by excess fluorescent light or injections of urethane, the retinal pigment epithelium (RPE) undergoes focal hyperplasia. Neither intravascularly injected horseradish peroxidase or lanthanum nitrate penetrated the sensory retina at these hyperplastic sites. Electron microscopy revealed that this was due to the persistence of intact, tight junctions among a single layer of hyperplastic cells facing the sensory retina. These junctions prevented intraocularly injected microperoxidase from passing as well. Cells within the hyperplastic foci were connected only by adherent junctions that presented no permeability barrier.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1090-6487
    Keywords: 78.55.Et ; 61.72.Nn ; 71.70.Ch ; 71.70.Ej ; 71.35.Cc
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Manifestations of bulk crystalline regions with stacking faults are detected in the reflection and photoluminescence spectra of CdS1-x Sex crystals with a variety of compositions. The magnitude of the crystal-field anisotropy and the spin-orbit splitting in these crystals are estimated. It is shown that reabsorption affects the form of the photoluminescence in crystals with stacking faults.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0827
    Keywords: Liposomes ; Hydroxyapatite ; Aggregation ; Atherosclerosis ; Calcification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary Some stages in the calcification of atherosclerotic plaques may involve associations between lipids and hydroxyapatite (HA) by surface interactions. Liposomes, artifical membranous lipid vesicles, have been used in this study as model structures for biological calcification processes. Liposome (containing cholesterol and phosphatidylcholine in most cases) suspensions were prepared by sonication, after which HA seed crystals were added to the suspensions and stirred at 37°C. Aliquots of the liposome suspensions were analyzed for particle size distribution and by transmission electron microscopy and electron diffraction. The results showed that HA induced aggregation of liposomes and modifications of the microscopic shapes of the liposomes in the aggregates. These data can be explained by the electron diffraction pattern where superimposition of liposome reflection and crystal reflection exists and may suggest organic-inorganic interaction. The potential of HA crystals to induce formation of liposome aggregates may be seen as a step in atherosclerotic plaques calcification.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: It has been hypothesized that changes in heating systems and insulation of homes in developed countries have generated an indoor climate favorable to organisms that excrete allergens inducing sensitization and allergic disease. The purpose of this study was to determine the influence of the installation of highly insulated windows and central heating systems on indoor climate, and mite-allergen (Der f 1) and mold spore concentrations. Methods: The bedrooms of 98 apartments were examined before and 7 months (mean) after installation of insulated windows and central heating systems. The air-exchange rate, temperature, and humidity were measured. In settled dust on carpets and mattresses, the number of colony-forming mold spores and the Der f 1 concentration were determined. The inhabitants completed a questionnaire about their lifestyles and housing conditions. Results: The air-exchange rate decreased from geometric mean 0.73 to 0.52 per hour (P=0.029). Temperature (mean 13.4 vs 17.5°C, P<0.001), and absolute humidity (mean 4.6 g vs 6.2 g H2O/kg air, P<0.001) increased. Relative humidity remained nearly unchanged (mean 47.6 vs 49.1%). Der f 1 concentrations on carpets (geometric mean 0.65 vs 1.28 μg/g dust, P<0.001) and mattresses (geometric mean 1.56 vs 2.40 μg/g, P=0.002) increased. Among the fungi that were analyzed, only the thermotolerant species Aspergillus fumigatus increased (geometric mean 20 vs 60 colony-forming units/g carpet dust, P=0.02). Conclusions: The findings of this study suggest that the installation of insulated windows and central heating systems is associated with an increase of Der f 1 concentrations in carpet and mattress dust and A. fumigatus in carpet dust in apartment bedrooms.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The oesophago-gastric junction functions as an anti-reflux barrier preventing increased exposure of the oesophageal mucosa to gastric contents. Failure of this anti-reflux barrier results in gastro-oesophageal reflux disease, and may lead to complications such as oesophagitis, Barrett’s oesophagus and eventually oesophageal carcinoma.Recent studies have suggested that transient lower oesophageal sphincter relaxation is the main mechanism underlying gastro-oesophageal reflux. It involves a prolonged relaxation of the lower oesophageal sphincter, mediated by a vago-vagal neural pathway, synapsing in the brainstem.Several drugs, such as atropine, baclofen and loxiglumide, have been shown to reduce the rate of transient lower oesophageal sphincter relaxations and concomitantly the number of reflux episodes. These findings illustrate that transient lower oesophageal sphincter relaxations may represent a potential new target for the pharmacological treatment of gastro-oesophageal reflux disease.It is possible that the reduction in the number of transient lower oesophageal sphincter relaxations may also contribute to the beneficial effect of fundoplication and new endoscopic anti-reflux procedures. It should be emphasized, however, that other factors, such as low lower oesophageal sphincter pressure, the presence of a hiatal hernia and impaired oesophageal peristalsis, are also of great importance. Therefore, whether the targeting of transient lower oesophageal sphincter relaxations is the ‘golden bullet’ in anti-reflux therapy remains to be proven, as evidence of an effective control of gastro-oesophageal reflux in reflux patients is still lacking.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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