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  • 1
    Keywords: Medicine ; Radiology, Medical ; Cardiology ; Medicine & Public Health ; Cardiology ; Diagnostic Radiology ; Springer eBooks
    Pages: : digital
    ISBN: 9781849960830
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  • 2
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    New York, NY : Springer Science+Business Media, LLC
    Keywords: Medicine ; Ophthalmology ; Medicine & Public Health ; Ophthalmology ; Springer eBooks
    Pages: : digital
    ISBN: 9781461401254
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  • 3
    Call number: QZ350:367
    Keywords: Multiple Myeloma / immunology ; Multiple Myeloma / genetics
    Description / Table of Contents: Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz
    Pages: xiii, 306 p. : ill.
    ISBN: 1588293920
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    QZ350:367 available
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  • 4
    Keywords: Life sciences ; Biotechnology ; Agriculture ; Life sciences ; Agriculture ; Biotechnology ; Plant Genetics and Genomics ; Springer eBooks
    Description / Table of Contents: RNA-seq Analysis in Plant-Fungus Interactions -- Study of Oil Palm Photosynthesis using Omics Technologies -- Molecular Marker Technology for Genetic Improvement of Underutilised Crops -- Transcription Factors Associated with Abiotic Stress and Fruit Development in Oil Palm -- Sensing Crop Diseases -- Development of Genomic Resources and Assessing their Potential for Accelerated Acacia Breeding -- Engineering of Secondary Metabolites in Tissue and Cell Culture of Medicinal Plants: An Alternative to Produce Beneficial Compounds using Bioreactor Technologies -- Bioreactor Technology for Sustainable Production of Valuable Plant Metabolites: Challenges and Advances -- Cisgenesis and Intragenesis as New Strategies for Crop Improvement -- Use of dsRNA in Crop Improvement -- Alternative Strategy in Crop Protection: Protease Inhibitors from Turmeric -- Sustainable Supply Chains: Utilisation of Whole Crops for New Product Development -- Food Losses in Rice Milling -- Elicitors and Their Roles in Plant Defence against Pathogens Particularly Basidiomycetes -- Induction of Systemic Resistance for Disease Suppression -- Tools and Targeted Genes for Plant Disease Detection
    Abstract: The book covers the latest development in the biosciences field covering key topics in crop improvement including €˜ómic approaches to improving sustainable crop production, advancement in marker technology, strategies in genetic manipulation, crop quality and sustainability and plant microbe interaction detailing on proven technologies to address critical issue for agricultural sustainability which are beneficial for researchers and students. The book also includes aspects of preserving crops after harvest as this is a key factor in promoting sustainable crop quality in terms of addressing waste, choosing the appropriate packaging and moving crops through the food and industrial supply chain.℗ An important strategy to overcome the challenges in providing food for the world population in a sustainable manner is through concerted efforts by crop scientists to embrace new technologies in increasing yield, quality and improving food safety while minimizing adverse environmental impact of the agricultural activities. ℗ Most of the proven molecular and genetic technologies in crop science have been tested and verified in model plants such as Arabidopsis and tomato. The technologies, when deployed on various plant species of importance for human nutrition and industrial applications, including cereals, vegetables, fruits, herbs, fibre and oil crops, face many challenges, not only due to their longer life cycle but many other physiological and environmental factors affecting yield and quality of plant products.℗ Furthermore, major impacts on crop production due to catastrophic diseases and global climate change needs urgent and innovative solutions. ℗ Therefore a℗ systematic approach, employing various leading-edge technologies that enable the functional elucidation of key pathway genes via €˜ómics tools, genome wide association with desired phenotypes and development of cost effective and practicable molecular tools for selection, is vital. The International Conference on Crop Improvement was held to address these and other pressing issues. ℗ This volume summarizes the keynote presentations from the meeting and highlights addition discussions that are critical to crop improvement in a challenging time
    Pages: XVIII, 388 p. 47 illus., 34 illus. in color. : online resource.
    ISBN: 9783319650791
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  • 5
    Call number: YY Diss Piet/Mag
    Keywords: DKFZ-publications / academic dissertations
    Pages: 65 p.
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    YY Diss Piet/Mag departmental collection or stack – please contact the library
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  • 6
    Keywords: Medicine ; Medical records / Data processing ; Medicine & Public Health ; Health Informatics ; Springer eBooks
    Pages: : digital.
    ISBN: 9781461434955
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  • 7
    Keywords: Medicine ; Internal Medicine ; Endocrinology ; Pediatrics ; Medicine & Public Health ; Endocrinology ; Internal Medicine ; Pediatrics ; Springer eBooks
    Pages: : digital
    ISBN: 9781607613176
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  • 8
    Keywords: Bacteriology ; Nucleic Acids ; Proteins  ; Medical Microbiology ; Bacteriology ; Nucleic Acid Chemistry ; Receptors ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
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  • 9
    Keywords: Bacteriology ; Nucleic Acids ; Proteins  ; Medical Microbiology ; Bacteriology ; Nucleic Acid Chemistry ; Receptors ; Medical Microbiology ; Springer eBooks
    Description / Table of Contents: Part I:Biochemistry/Structural Biology – Enzymes -- Chapter 1: Cyclic Dinucleotide Signaling In Mycobacteria -- Chapter 2: Structure and regulation of EAL domain proteins -- Chapter 3: Insights into the molecular basis of biofilm dispersal from crystal structures of di-domain containing proteins -- Chapter 4: Structure and function of HD-GYP phosphodiesterases -- Chapter 5: A unified catalytic mechanism for c-di-NMP hydrolysis by DHH/DHHA1 phosphodiesterases -- Chapter 6: Enzymatic degradation of linear dinucleotide intermediates of cyclic dinucleotides -- Part II:Biochemistry/Structural Biology – Receptors -- Chapter 7: Detection of cyclic dinucleotide binding proteins -- Chapter 8: Non-canonical c-di-GMP binding modes -- Part III:Biochemistry/Structural Biology – Sensing -- Chapter 9: Sensory domains that control cyclic di-GMP-modulating proteins: a critical frontier in bacterial signal transduction -- Part IV:Cyclic di-AMP biochemistry and physiology -- Chapter 10: Metabolic regulation by cyclic di-AMP signaling -- Chapter 11: Osmoregulation via cyclic-di-AMP signaling -- Part V:Population diversity -- Chapter 12: Measuring individual cell c-di-GMP: Identifying population diversity and c-di-GMP heterogeneity.-Part VI:Cyclic di-GMP and exopolysaccharide regulation -- Chapter 13: Activation of bacterial cellulose biosynthesis by cyclic-di-GMP -- Chapter 14: The Regulation of Alginate Biosynthesis viaC-di-GMPSignaling -- Part VII:Environmental bacteria -- Chapter 15: Cyclic di-GMP Signaling in Bacillus subtilis -- Chapter 16: C-di-GMP signaling systems in the Gram-positive Bacillus cereus group -- Chapter 17: Cyclic-di-AMP in Bacillus subtilisbiofilm formation.-Chapter 18: Regulation by c-di-GMP in Myxococcusxanthus -- Chapter 19: Light-regulated nucleotidesecond messenger signalingin cyanobacteria -- Chapter 20: C-di-GMP-dependent regulation of antibiotic biosynthesis in Lysobacter -- Chapter 21: Cyclic di-GMP signalingin extreme acidophilic bacteria -- Part VIII:Pathogens -- Chapter 22: Signals modulating cyclic di-GMP pathways in Vibrio cholera -- Chapter 23: Cyclic di-GMP regulation of gene expression -- Chapter 24: Cyclic di-GMP signaling in Salmonella enterica serovar Typhimurium -- Chapter 25: Cyclic di-GMP signaling in the phytopathogen Xanthomonas campestris pv. Campestris -- Chapter 26: Cyclic di-AMP in Mycobacterium tuberculosis -- Chapter 27: Cyclic di-AMP signaling in Streptococcus pneumonia -- Part IX:Gram-negative bacteria -- Chapter 28: Regulation of cyclic-di-GMP signaling in Pseudomonas aeruginosa -- Chapter 29: Unconventional Cyclic di-GMPSignalling in Escherichia coli -- Chapter 30: Cyclic di-GMP in Burkholderia spp -- Chapter 31: Cyclic di-GMP and the regulation of biofilm dispersion -- Part X:Cyclic di-GMP signaling in eukaryotes -- Chapter 32: Cyclic-di-GMP activates adenylate cyclase A and protein kinase A to induce stalk formationin Dictyostelium -- Part XI:Interference Strategies -- Chapter 33: Targeting cyclic di-nucleotide signaling with small molecules -- Part XII:Novel cyclic di-nucleotides -- Chapter 34: Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes -- Chapter 35: Microbial cyclic GMP-AMP signaling pathways.-Part XIII:Honorary cyclic nucleotides -- Chapter 36: 2’,3’-cyclic mononucleotide metabolism and possible roles in bacterial physiology -- Part XIV:Horizontal gene transfer -- Chapter 37: Horizontal transfer of c-di-GMP associated genes. Theoretical underpinnings and future perspectives.-Part XV:Conclusion -- Chapter 38: Conclusion
    Abstract: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions
    Pages: XVIII, 657 p. 108 illus., 96 illus. in color. : online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030333089
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  • 10
    Keywords: Biomedical Engineering ; Biomedical Engineering/Biotechnology ; Regenerative Medicine/Tissue Engineering ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: I.The Fate of Stem Cell by Biomaterials -- 1.Biomaterials for stem cell homing in in situ tissue regeneration -- 2.A novel strategy for simple and robust expansion of human-induced pluripotent stem cells using botulinum hemagglutinin -- 3.Growth and differentiation of the stem cells of dental apical papilla on polycaprolactone-based scaffolds -- 4.Impact of three-dimentional culture systems on hepatocyte differentiation and beyond, Thamil Selvee Ramasamy -- II.Controlling of Signal Pathway of Stem Cell by Biomaterials -- 5.Modulation of inflammatory reaction in the development of biomaterials for osteogenesis -- 6.Novel Physiologically mimicking biomatix platform for advancing regeneration and re-creating organ capillaries -- 7.Silk fibroin participates wound healing processes via NF-kB signaling -- 8.The role of natural-based polymers in advanced therapies for autoimmune diseases -- III.Functional Biomaterials for Regenerative Medicine -- 9.Applications of biomimetic hydrogel-based materials for musculoskeletal tissue engineering -- 10.Injectable biomaterials for regenerative medicine -- 11.Advanced injectable alternatives for osteoarthritis -- 12.Engineering of hydrogel materials for biomedical applications -- 13.Injectable nanocomposite hydrogel for biomedical applications -- 14.Advances in waterborne polyurethane-based biomaterials for biomedical applications -- 15.Medical applications of collagen and hyaluronan in regenerative medicine -- IV.Inorganic Biomaterials for Regenerative Medicine -- 16.Calcium phosphate biomaterials for clinical application in dentistry -- 17.Novel biodegradable metals for regenerative medicine -- 18.Stem cell and advanced nano bioceramic interactions -- 19.Fabrication of nano-hydroxyapatite by hydrothermal treatment for biomedical applications -- 20.Use of TiO2 in the bone regeneration -- V.Smart Natural Biomaterials for Regenerative Medicine -- 21.Natural gum-based scaffolds for tissue engineering and regenerative medicine -- 22.Silk for bone regeneration -- 23.Collagen type I: A versatile biomaterial -- 24.Naturally derived and artificially engineered cellular matrices for regenerative medicine -- 25.Natural ECM biomaterial for tissue engineering applications -- 26.Mussel-inspired biomaterials for cell and tissue engineering -- 27.Tissue engineered skin grafts based on natural/synthetic polymers -- 28.Demineralized dentin matrix as a carrier of recombinant human bone morphogenetic proteins -- 29.Prospects of natural polymeric scaffolds in nerve tissue-regeneration -- 30.Chitosan-based dressing materials for problematic wound management
    Abstract: This book explores in depth a wide range of new biomaterials that hold great promise for applications in regenerative medicine. The opening two sections are devoted to biomaterials designed to direct stem cell fate and regulate signaling pathways. Diverse novel functional biomaterials, including injectable nanocomposite hydrogels, electrosprayed nanoparticles, and waterborne polyurethane-based materials, are then discussed. The fourth section focuses on inorganic biomaterials, such as nanobioceramics, hydroxyapatite, and titanium dioxide. Finally, up-to-date information is provided on a wide range of smart natural biomaterials, ranging from silk fibroin-based scaffolds and collagen type I to chitosan, mussel-inspired biomaterials, and natural polymeric scaffolds. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth the latest enabling technologies for regenerative medicine
    Pages: XI, 537 p. 163 illus., 105 illus. in color. : online resource.
    ISBN: 9789811309472
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