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  • 1
    Online Resource
    Online Resource
    Cham : : Springer International Publishing, | Cham : : Springer International Publishing :
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: XVIII, 388 p. 47 illus., 34 illus. in color. , online resource.
    ISBN: 9783319650791
    Language: English
    Note: RNA-seq Analysis in Plant-Fungus Interactions -- Study of Oil Palm Photosynthesis using Omics Technologies -- Molecular Marker Technology for Genetic Improvement of Underutilised Crops -- Transcription Factors Associated with Abiotic Stress and Fruit Development in Oil Palm -- Sensing Crop Diseases -- Development of Genomic Resources and Assessing their Potential for Accelerated Acacia Breeding -- Engineering of Secondary Metabolites in Tissue and Cell Culture of Medicinal Plants: An Alternative to Produce Beneficial Compounds using Bioreactor Technologies -- Bioreactor Technology for Sustainable Production of Valuable Plant Metabolites: Challenges and Advances -- Cisgenesis and Intragenesis as New Strategies for Crop Improvement -- Use of dsRNA in Crop Improvement -- Alternative Strategy in Crop Protection: Protease Inhibitors from Turmeric -- Sustainable Supply Chains: Utilisation of Whole Crops for New Product Development -- Food Losses in Rice Milling -- Elicitors and Their Roles in Plant Defence against Pathogens Particularly Basidiomycetes -- Induction of Systemic Resistance for Disease Suppression -- Tools and Targeted Genes for Plant Disease Detection.
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  • 2
    Online Resource
    Online Resource
    Singapore : : Springer, | Singapore : : Springer Singapore :
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: X, 405 p. 58 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789811399138
    Series Statement: Advances in Experimental Medicine and Biology, 1175
    Language: English
    Note: Introduction to neuroglia: history, definition, development and main functions -- Evolution of astroglia -- Physiology of astroglia -- Glicoryne system: glial cells as secretory cells of the CNS -- Physiology of oligodendroglia and NG-2 glia -- Physiology of microglia -- General pathophysiology of neuroglia -- Neuroglia in ageing -- In vivo imaging of neuroglia in neurodegenerative diseases -- Astroglia in leukodystrophies -- Astrocytes in ALS -- Astroglia in Alzheimer's disease -- Oligodendrogia in Alzheimer's disease -- Microglia in AD -- Neuroglia in Parkinson's disease -- Neuroglia in Huntington disease -- Neuroglia as a therapeutic target -- Stem cell derived neuroglia: new tool for research and treatment of neurodegenerative diseases.
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  • 3
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9781607613176
    Series Statement: Contemporary endocrinology
    Language: English
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  • 4
    Type of Medium: Book
    Pages: 65 p.
    Language: German
    Note: Thesis (diploma) -- Universität Hannover, Hannover, 2006.
    Location: DKFZ
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  • 5
    Online Resource
    Online Resource
    Singapore : : Springer Singapore :
    In: Springer Nature eBook
    Description / Table of Contents: This book presents the latest knowledge and the most recent research results in the field of ganglioside biochemistry. The early chapters cover all relevant background on sialic acids and their biosynthesis, on N-glycolylneuraminic acid (Neu5Gc), which cannot be synthesized by humans, and on general aspects of ganglioside research. Ganglioside adsorption, disorders of ganglioside degradation, and the regulation of gangliosides are thoroughly discussed. A major focus of the book is the role of gangliosides in cancer. Here, the discussion encompasses, for example, the biological importance, antigenicity, and immunological actions of tumor-associated gangliosides (TAGs), the significance of different glycolipids and gangliosides as TAGs, and emerging anti-cancer vaccine strategies. The ability of sialic acids and TAGs of tumor cells to escape immunosurveillance and immunoediting also receives detailed attention. The significance of sialic acids in regulation of the complement system is explained, and the closing chapter focuses especially on the role of sialyl T antigen in cancer. The book will be of value for all who are interested in functional glycobiology and glycomic studies.
    Type of Medium: Online Resource
    Pages: XVI, 214 p. 57 illus., 48 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811558153
    Language: English
    Note: Preface: Carbohydrates- the third life chain -- 1. Glycosylation -- 2. N-Glycan and O-glycan glycosylation in eukaryotes -- 3. Sialyltransferase, sialylation and sulfoylation -- 4. Congenital disorders of glycosylation (CDG) of N-glycoprotein -- 5. Neuraminic acids/sialic acids (N-acetyl- and N-glycolylneuraminic acid) -- 6. Biosynthesis of sialic acid -- 7. Neu5Gc (N-glycolylneuraminic acid) -- 8. Gangliosides -- 9. Gangliosides and tumor-associated ganglioside (TAG) modulate receptor-tyrosine kinases (RTKs) -- 10. Sialic acids and TAGs of tumor cells to escape immunesurveillance and immuneediting -- 11. Tumor characteristics in tumor related carbohydrates.
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  • 6
    Online Resource
    Online Resource
    Singapore : : Springer Singapore :
    In: Springer Nature eBook
    Description / Table of Contents: This book reviews recent progress in understanding of the signaling and biochemistry of GM3 ganglioside in eukaryotic cells. GM3 is the simplest of the gangliosides and the precursor of other gangliosides. It is expressed in the outer leaflet of plasma cell membranes and has roles in the recognition, interaction, binding, adhesion, and motility of cells. In addition, GM3 has been documented to have functional roles in cell migration, proliferation, senescence, and apoptosis. The full range of topics of interest are addressed in the book. The early chapters discuss the synthesis of GM3, its molecular localization in cells, and its basic function as an interacting molecule. The ways in which GM3 exerts its effects via various growth factor receptors are fully explored. Current knowledge of the part played by GM3 in health and disease is discussed in depth. For example, its roles in preventing inflammation, inhibiting tumor angiogenesis and tumor growth, and suppressing arthritis are highlighted, and attention drawn to the significance of GM3 as a driver of impaired wound healing in diabetics. The book will be of interest to all who want a comprehensive update on research in this field.
    Type of Medium: Online Resource
    Pages: VII, 138 p. 32 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811556524
    Language: English
    Note: 1. History of sialic acids, gangliosides and GM3 -- 2. Synthesis of GM3 -- 3. Molecular localization of GM3 in cells -- 4. Basic function of GM3 as an interacting molecule -- 5. GD3 mimetics with a neurite forming capacity -- 6. GM3 as a pathogenic infection receptor -- 7. GM3 and related gangliosides prevent inflammation and atherosclerosis -- 8. GM3 has an anti-tumor capacity -- 9. GM3 suppresses tumor angiogenesis -- 10. Interaction between EGFR and GM3 -- 11. Membrane ganglioside-specific neuraminidase 3 (NEU3) regulates GM3 signaling -- 12. Regulation of GM3-mediated EGFR signaling by NEU3 sialidase -- 13. VEGFR-GM3 interaction in angiogenesis -- 14. GM3, competing with GM1, interaction with urokinase plasminogen activator receptor (uPAR) in endothelial caveolar-lipid rafts inhibits angiogenesis -- 15. GM3 interacts with TGFβ Rs in the epithelial-mesenchymal transition (EMT) during posterior capsular opacification (PCO) formation -- 16. Galectin-1 promotes tumor growth and escapes immune surveillance -- 17. GM3-HGFR, FGFR and PDGFR cancer cell behavior, and IGF-1R in diabetic wound healing -- 18. GM3, caveolin-1 and insulin receptor in insulin resistance -- 19. GM3 suppresses arthritis -- 20. GM3 protects cochlear hair cells and hearing from corti degeneration -- 21. GM3 increases osteoclast differentiation via direct GM3 cooperation with RANKL and IGF-1 -- 22. GM3 in leukemic cells into terminal differentiation -- 23. α2,3-Sialyllactose (3SL) or α2,6-sialyllactose (6SL) of GM3 glycan in innate immunity. .
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  • 7
    Call number: QZ200:377
    Type of Medium: Book
    Pages: 36 p
    Language: English
    Location: DKFZ
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  • 8
    Book
    Book
    Totowa, N.J. : : Humana Press,
    Call number: QZ350:367
    Type of Medium: Book
    Pages: xiii, 306 p. : , ill.
    ISBN: 1588293920 (alk. paper) , 1592599168 (e-ISBN)
    Series Statement: Methods in molecular medicine ;
    Language: English
    Note: Multiple myeloma: challenges and opportunities / Douglas Joshua, Ross D. Brown, and P. Joy Ho -- Immunophenotyping of plasma cells in multiple myeloma / Gema Mateo Manzanera, Jesús F. San Miguel Izquierdo, and Alberto Orfao de Matos -- Plasma cell labeling index / Philip R. Griepp and Shaji Kumar -- Conventional cytogenetics in myeloma / Lynda J. Campbell -- Multicolor spectral karyotyping in multiple myeloma / Jeffrey R. Sawyer -- Detection of chromosome 13 deletions by fluorescent in situ hybridization / Scott VanWier and Rafael Fonseca -- Comparative genomic hybridization for analysis of changes in DNA copy number in multiple myeloma / Pulivarthi H. Rao -- Southern blotting of IgH rearrangements in B-cell disorders / Edna Yuen and Ross D. Brown -- Identification and assembly of V genes as idiotype-specific DNA fusion vaccines in multiple myeloma / Surinder S. Sahota, Mark Townsend, and Freda K. Stevenson -- Identification of clonotypic IgH VDJ sequences in multiple myeloma / Brian J. Taylor ... [et al.] -- Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in myeloma / Mara Compagno ... [et al.] -- Incomplete DJH rearrangements / David González and Ramón Garcia-Sanz ... , Identification of malignant plasma cells by mRNA in situ hybridization / Ross D. Brown and P. Joy Ho -- The SCID-hu myeloma model / Joshua Epstein and Shmuel Yaccoby -- The 5T2MM murine model of multiple myeloma: maintenance and analysis / Karin Vanderkerken ... [et al.] -- Determination of telomerase activity and telomere length / Kai-da Wu and Malcolm A.S. Moore -- Dendritic cell/myeloma hybrid vaccine / Dajing Xia, Tim Chan, and Jim Xiang -- Genetically engineered myeloma cell vaccine / Siguo Hao, Tim Chan, and Jim Xiang -- An in vitro osteoclast-forming assay to measure myeloma cell-derived osteoclast-activating factors / Andrew C.W. Zannettino ... [et al.] -- Clonality detection of the expanded T-cell populations in patients with multiple myeloma / Daniel M-Y. Sze -- Detecting mismatch repair defects in myeloma / Mark Velangi ... [et al.] -- Methylation-specific polymerase chain reaction / Oliver Galm and James G. Herman -- Making sense of DNA microarray data / Wei-min Liu, Sunhee K. Ro, and Walter H. Koch.
    Location: DKFZ
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  • 9
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9781849960830
    Language: English
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  • 10
    Online Resource
    Online Resource
    New York, NY : : Springer Science+Business Media, LLC,
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9781461401254
    Language: English
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