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  • 1
    ISSN: 1432-0738
    Keywords: Skin tests ; Delayed hypersensitivity ; Classification and labelling of dangerous substances
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Current European Community (Annex V) guidelines recommend the use of 20 test animals in the guinea pig maximisation test for skin sensitisation. The suitability, for classification and labelling purposes, of reducing the number of test animals has been examined by analysing the results of 40 studies submitted to the Health and Safety Executive, and by the use of a mathematical model. Our results suggest that in most cases an experiment with ten test animals can be used to determine satisfactorily whether a substance should be labelled with the risk phrase “may cause sensitisation by skin contact”. However, serious consideration should be given to the need for additional investigation if two or three of the ten test animals show a sensitisation response. The highest nonirritant concentration of a substance should be used at challenge. Clearer guidance in Annex V on evaluating challenge responses would be beneficial.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 32 (1955), S. 31-42 
    ISSN: 1420-9136
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Description / Table of Contents: Résumé Depuis déjà plusieurs années le Dominion Observatory emploie la méthodeByerly pour étudier la direction des dislocations causées par les trembrements de terre et 34 séismes en tout ont été analysés jusqu'à présent. Pour tous ces tremblements de terre, sauf 3, la solution s'appuie sur des données fournies par des investigateurs de séismes, qui ont collaboré en répondant à des questionnaires. A la lumière des résultats obtenus à date nous pouvons conclure que la faille transversale a joué un rôle plus important dans l'évolution tectonique qu'on ne lui en attribue normalement. Dans la région partant de l'Alaska, passant par la colombie Britannique, et allant jusqu'à Seattle, la faille transversale est prédominante dans seulement 2 des 6 tremblements de terre, cependant qu'ailleurs la faille transversale semble être de règle. Des 10 tremblements de terre survenus dans le sud de l'océan Pacifique, un au Japon et 6 aux îles Kouriles qui ont été analysés, tous demontrent une dislocation horizontale pour des profondeurs de centre variant de moins que la normale jusqu'à 550 km. Dans les Aléoutiennes 2 des 3 séismes analysés et dans l'Amérique du Sud 4 des 5, résultaient de failles transversales. Le centre d'un des tremblements de terre en Amérique du Sud se trouvait à 600 km de profondeur. Si les résultats des traterre vaux subséquents continuent d'augmenter l'importance de la faille transversale, les théories déjà existantes de l'écroulement de la terre devront être modifiées. Cette étude pourrait être sensiblement accélée si les données du mouvement premier des tremblements de terre étaient ajoutées aux Bulletins des stations séismologiques. Nous insistons fortement pour que cette mesure soit adoptéc.
    Notes: Summary For the past several years the Dominion Observatory at Ottawa has been applyingByerly's method to study the direction of faulting in earthquakes, a total of 34 earthquakes having been analysed to date. For all but 3 of these earthquakes the solutions have been based on data supplied by co-operating seismologists through the medium of questionnaires. It is the conclusion of the work to date that transcurrent faulting plays a more important part in tectonic processes than is normally ascribed to it. In the area from Alaska through the British Columbia coast to Seattle only 2 out of 6 earthquakes were predominately transcurrent, but elsewhere transcurrent faulting appears to be the rule. Of 10 earthquakes from the Southwest Pacific, 1 from Japan and 6 from the Kuriles so far analysed, all exhibit transcurrent faulting, for depths of focus ranging from less than normal to 550 km. In the Aleutians 2 of the 3 earthquakes analysed, and in South America 4 of the 5, resulted from transcurrent faults. The group of South American earthquakes included one at 600 km. If subsequent work should continue to give evidence of the importance of transcurrent faulting, existing theories of the earth's failure will have to be modified. Such studies could be speeded up very much if all stations would include data on first motion in their bulletins. A strong plea is made that this should be done.
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 62 (1991), S. 96-99 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An atomic hydrogen beam source, compatible with ultrahigh vacuum and clean surface conditions, has been developed. Hydrogen atoms (H0) of thermal energy distribution are produced by dissociation of hydrogen molecules in a radio-frequency (rf) glow discharge. The resulting mixture of atoms and molecules is allowed to flow from the discharge vessel to the vacuum test chamber through a capillary, resulting in the formation of a beam. Dissociation fractions [ 1/2 H0/(H2+ 1/2 H0)] of 〉0.5 and H0 fluxes of 〉2×1017 H0/s were achieved. Locating the rf power source adjacent to the discharge vessel resulted in a compact device which is easy to maintain and operate.
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 21 (2003), S. 113-114 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The French prime minister, Jean-Pierre Raffarin, and his ministerial colleagues for industry and research announced in mid-December a package of tax-cutting measures for research-based companies that industry representatives have broadly welcomed. If approved by the French parliament, French ...
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 205-205 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As part of a continuing program of support for the Cartagena Protocol on BioSafety, worth around $100 million, the United Nations Environment Program (UNEP; Nairobi, Kenya) has launched a $38.4 million scheme to help establish up to 100 biosafety administrative bodies in developing ...
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  • 6
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 3-4 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Research at the International Maize and Wheat Improvement Center (CIMMYT; El Batan, Mexico) has cast some doubt on controversial earlier reports that DNA from genetically modified maize has been transferred to local varieties in Mexico. Although the earlier work describes the apparently widespread ...
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 20 (2002), S. 859-860 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A political tiff surrounding the UK government's choice of vaccine strain to combat threats of a smallpox epidemic caused by bioterrorism has reopened the debate about the effectiveness of homeland security measures worldwide. Most experts seem to agree that there is little or no technical reason ...
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 495-495 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Preempting UK Prime Minister Tony Blair's call for a general election at the beginning of May, the UK's BioIndustry Association (BIA; London) published it's “Manifesto for Biotechnology” on April 26th. In it, the BIA highlights several specific areas for government action such as animal ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 397-398 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A report from the European Parliament (Strasbourg, France) on biotechnology has some very positive things to say about the potential of the field in Europe and makes many recommendations on specific ways in which Europe can improve its performance in both the spheres that underpin biotechnology and ...
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature biotechnology 19 (2001), S. 1089-1089 
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Loans backed by French government guarantees could allow French companies to take advantage of current distressed valuations in biotechnology by embarking on acquisitive sprees in Germany, the United Kingdom, or the United States. The proposal for Plan Biotech 2002, which is to go before the French ...
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