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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  14. Internationales SkillsLab Symposium 2019; 20190329-20190330; Brandenburg (Havel)/Neuruppin; DOCV03-01 /20190325/
    Publication Date: 2019-03-26
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 0378-4371
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters B 222 (1989), S. 263-268 
    ISSN: 0370-2693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-8798
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Several types of cell strains and established cell lines of simian and human origin failed to demonstrate foci of altered cells following infection with the Mason-Pfizer monkey virus (M-PMV). However, most diploid cultures, after infection, lived longer and displayed the ability to grow in soft agar medium. The number of cell colonies developing in the soft agar was directly proportional to the amount of virus added to the culture. Two types of cell colonies were isolated from soft agar after infection of monkey foreskin cells with M-PMV. One had characteristic fibroblastic morphology, and the other showed an epithelioid cell phenotype. The ratio of fibroblastic colonies to epithelioid colonies was in excess of 20:1. The epithelioid cultures displayed a complete lack of topoinhibition, formed three dimensional cellular dome structures, and demonstrated significant karyotypic alterations. Fibroblastic sublines, on the other hand, did not show formation of domes but presented some lack of topoinhibition. The majority of cells in fibroblastic sublines also continued to show a normal rhesus chromosome complement. Although both epithelioid and fibroblastic transformed cell types produced intracellular M-PMV antigen and virus particles, the infectious virus titers were significantly different. The noninfectious virus preparations recovered from some of the fibroblastic sublines contained a high percentage of aberrant forms of M-PMV.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 80 (1968), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: SUMMARY.— Economic pressures have brought about a change in the conductors of electrical power cables; aluminium is now widely used in place of copper. The development of a jointing flux containing aminoethylethanolamine made this possible, and this has been very extensively used by the Electricity Supply Industry in this country. This amine has given rise to a high incidence of dermatitis amongst cable jointers, and is here shown to be a powerful sensitizer. Surveys have shown an incidence of dermatitis of 10% to more than 30%, in all grades of severity.A satisfactory alternative flux has been developed and is now in field use. This investigation underlines many principles of economic as well as medical importance.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract We consider eigenvaluesE λ of the HamiltonianH λ=−Δ+V+λW,W compactly supported, in the λ→∞ limit. ForW≧0 we find monotonic convergence ofE λ to the eigenvalues of a limiting operatorH ∞ (associated with an exterior Dirichlet problem), and we estimate the rate of convergence for 1-dimensional systems. In 1-dimensional systems withW≦0, or withW changing sign, we do not find convergence. Instead, we find a cascade phenomenon, in which, as λ→∞, each eigenvalueE λ stays near a Dirichlet eigenvalue for a long interval (of lengthO( $$\sqrt \lambda $$ )) of the scaling range, quickly drops to the next lower Dirichlet eigenvalue, stays there for a long interval, drops again, and so on. As a result, for most large values of λ the discrete spectrum ofH λ is close to that ofE ∞, but when λ reaches a transition region, the entire spectrum quickly shifts down by one. We also explore the behavior of several explicit models, as λ→∞.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Abstract A recently established general trace formula for one-dimensional Schrödinger operators is systematically studied in the context of short-range potentials, potentials which approach different spatial asymptotes sufficiently fast, and appropriate impurity (defect) interactions in one-dimensional solids. We prove the absolute summability of the trace formula and establish its connections with scattering quantities, such as reflection coefficients, in each case.
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  • 8
    ISSN: 1432-0851
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Clearance of IV-injected tumor cells has been correlated with levels of natural killer (NK) cell activity in recipient animals. Studies of in vivo tumor cell clearance strongly suggest a relationship between levels of NK cell activity and antitumor or antimetastatic effector function. This study outlines the applicability of three radiolabels, [125I]iododeoxyuridine, ([125I]dUrd), indium-111-oxine chelate ([111In]Ox), and chromium-51 (51Cr), to studies of tumor cell clearance in vivo. The suitability of these labels for analysis of the in vivo migration patterns of normal lymphocytes or thymus-derived T cells cultivated in vitro (CTC) is also discussed. The results indicate that [111In]Ox and 51Cr compare favorably with the more widely used [125]dUrd as radiolabels for the assessment of IV-injected tumor cell clearance from the lungs of mice. The rates of clearance of both [111In]Ox and 51Cr, like that for [125I]dUrd, correlate closely with levels of NK-cell activity of the host. Further studies with [111In]Ox reveal that treatment of recipients with anti-asialo GM1 serum, a regimen known to suppress NK-cell activity, demonstrates the appropriate reduction in isotope clearance from the lungs after NK suppression. However, clearance data obtained by monitoring levels of radioactivity in the liver after IV injection must be viewed cautiously, since the same cells labeled with [111In]Ox and [125I]dUrd had a different pattern of clearance from the liver. The same inconsistencies in clearance were observed when [111In]Ox and [125I]dUrd were injected intrafootpad (i.f.p.). Similar effects were observed when [111In]Ox or 51Cr was applied to studies of CTC migration. Levels of [111In]Ox and 51Cr remained high in the liver after IV injection, while [125I]dUrd was rapidly cleared. Normal spleen or thymic lymphocytes exhibited the expected homing to the spleen after labeling with [111In]Ox, indicating a suitability of this label for migration studies, except possibly in the liver. These results with CTC and normal lymphocytes should be considered during the formulation of immunotherapy protocols based on cell migration data, since the choice of radiolabel can result in widely divergent levels of radioactivity accumulated in some organs, and may not provide an accurate representation of the presence of viable, intact, or functional cells.
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  • 9
    ISSN: 1420-9071
    Keywords: Key words. Carbamoyl phosphate synthetase; substrate channeling; pyrimidine metabolism; arginine biosynthesis; ATP-grasp enzyme; amidotransferase.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Carbamoyl phosphate synthetase (CPS) catalyzes one of the most remarkable reactions ever described in biological chemistry, in which carbamoyl phosphate is produced from one molecule of bicarbonate, two molecules of Mg2+ATP, and one molecule of either glutamine or ammonia. The carbamoyl phosphate so produced is utilized in the synthesis of arginine and pyrimidine nucleotides. It is also employed in the urea cycle in most terrestrial vertebrates. Due to its large size, its important metabolic role, and the fact that it is highly regulated, CPS has been the focus of intensive investigation for nearly 40 years. Numerous enzymological, biochemical, and biophysical studies by a variety of investigators have led to a quite detailed understanding of CPS. Perhaps one of the most significant advances on this topic within the last 2 years has been the successful X-ray crystallographic analysis of CPS from Escherichia coli. Quite unexpectedly, this structural investigation revealed that the three active sites on the protein are widely separated from one another. Furthermore, these active sites are connected by a molecular tunnel with a total length of approximately 100 Å, suggesting that CPS utilizes this channel to facilitate the translocation of reaction intermediates from one site to another. In this review, we highlight the recent biochemical and X-ray crystallographic results that have led to a more complete understanding of this finely tuned instrument of catalysis.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Nous avons trouvé le virus SV40 chez le singeCercopithecus aethiops présumé non infecté. Par la méthode de culture des cellules du rein et en effectuant des passages rapides nous avons pu démontrer l'existence du virus même chez les animaux dépourvus d'anticorps et même dans le cas où le virus n'apparaissait pas durant le premier passage.
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