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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 194 (1994), S. 251-264 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 115 (1986), S. viii 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physics Letters A 194 (1994), S. 251-264 
    ISSN: 0375-9601
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A genetic technique for insect population control has been tested in cages under field conditions at two different locations in British Columbia. The method entails the population replacement of standard insects by those bearing compound autosomes using the principle of negative heterosis, thus permitting control or elimination through conditional mutations. Both native- and laboratory-derived compound strains of the fruitfly Drosophila melanogaster were tested in population cages against standards in the laboratory and at the two field sites. Those compound-bearing insects originating from the wild were the most successful, both in the laboratory and the field, in displacing standards from the cages down to a minimum initial ratio of 5 compounds to 1 standard. The importance is stressed of collecting strains from the wild, and performing the necessary genetic manipulations as rapidly as possible, prior to releasing the rearrangement in the field for control purposes.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2242
    Keywords: Compound ; free-arm strains ; Drosophila melanogaster ; Unstable genetic isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Crosses between compound-2L; free-2R (free-arm) and standard strains of Drosophila melanogaster produce two classes of inviable aneuploid hybrids in equal proportions: monosomic 2L and trisomic 2L. The lethal period for monosomics occurs during embryogenesis while the trisomics survive to late pupae. Since the hybrids are inviable, standard and free-arm strains within a mixed population remain genetically isolated. Genetic isolation in the absence of mating isolation offers an extreme example of unstable equilibrium. Relative fitness data indicate that an unstable equilibrium will be established between free-arm and standard strains at a ratio of 2.5∶1. Indeed, in three cage experiments established at initial ratios of 3∶1, free arms to standards, laboratory (Oregon R) or native (Okanagan S) standard strains were completely replaced in approximately 100 days by free-arm lines derived either from laboratory or from native genetic background. In contrast, one cage established at an initial ratio of 4∶1 failed to show replacement and for 92 days remained at approximately the initial ratio. Subsequent genetic analysis of flies removed from this cage identified the presence of an anomalous strain through which genetic information was transferred reciprocally between the free-arm and standard lines. The second chromosomes carried by this strain consisted of a free-2R and a standard second on the right arm of which was attached a duplication for all of 2L. While the origin of the 2L·2R+2L chromosome was uncertain, genetic and cytological examinations revealed that it represented the reciprocal crossover product expected from an exchange that generated a F(2R). Additional crosses disclosed that the transmission frequency of the asymmetrical pair of second chromosomes, as well as their right-arm crossover products, was disproportionately in favor of the short arm. Since unequal transmission was invariably greater from female parents, this phenomenon was viewed as further evidence in support of the drag hypothesis.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Hypotonische Streuungen, die in radiobestrahlten Kulturen menschlicher Lymphozyten Chromosomenaberrationen erkennen liessen, traten dort siebenmal häufiger auf als in unbestrahlten Kulturen; offenbar das Ergebnis einer wärmefreien Bestrahlung. Trotz des Fehlens bedeutender Unterschiede in der DNA-Synthese, der Zellvergrösserung und im mitotischen Index zwischen bestrahlten und unbestrahlten Kulturen kam es zu Aberrationen.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 31 (1990), S. 1610-1615 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Moment invariants [functions of the moments of a Vlasov distribution that are invariant under Sp(6)] are classified using Young diagrams. The connection between the moment invariants and the Poincaré invariants is established. An application using the moment invariants as phase space coordinates is considered for a matching section in a particle-beam accelerator, and a Lie–Poisson numerical integration algorithm for the moment dynamics is proposed.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1467
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Physics
    Notes: Summary The real-valued Maxwell-Bloch equations on ℝ3 are investigated as a Hamiltonian dynamical system obtained by applying an S1 reduction to an invariant subsystem of a dynamical system on ℂ3. These equations on ℝ3 are bi-Hamiltonian and possess several inequivalent Lie-Poisson structures parametrized by classes of orbits in the group SL(2, ℝ). Each Lie-Poisson structure possesses an associated Casimir function. When reduced to level sets of these functions, the motion takes various symplectic forms, from that of the pendulum to that of the Duffing oscillator. The values of the geometric (Hannay-Berry) phases obtained in reconstructing the solutions are found to depend upon the choice of Casimir function, that is, upon the parametrization of the reduced symplectic space.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1440
    Keywords: Nifedipine gastrointestinal therapeutic system ; Essential hypertension ; Ambulatory blood pressure measurement
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The nifedipine gastrointestinal therapeutic system (GITS) is a recently developed controlled-release formulation for once-a-day dosing. We evaluated the influence of morning versus evening administration of the drug in a randomized double-blind cross-over study including 15 essential hypertensives. Five patients had to be excluded from blood pressure analysis because of noncompliance (three cases) or intolerable side effects (two cases). To assess the exact duration of the antihypertensive efficacy noninvasive automatic ambulatory blood pressure monitoring was performed. After a placebo period patients were given 30 mg nifedipine GITS either at 1000 or 2200 hours. Twenty-four-hour systolic and diastolic blood pressure profiles documented a sustained antihypertensive effect of both nifedipine regimens throughout the whole period without affecting the circadian rhythm. Statistical analysis revealed no significant difference between morning and evening administration. Two patients stopped their medication because of intolerable side effects (fatigue and muscle cramps, respectively). Two more cases suffered from mild reversible headache which provoked no discontinuation of the drug. In conclusion our results document a sustained antihypertensive efficacy of 30 mg nifedipine GITS in patients with moderate essential hypertension. Time of administration has no impact on day- and nighttime blood pressure control.
    Type of Medium: Electronic Resource
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  • 10
    Publication Date: 2018-04-28
    Description: Introduction An unbalanced intestinal microbiota may mediate activation of the inflammatory pathways seen in psoriatic arthritis (PsA). A randomised, placebo-controlled trial of faecal microbiota transplantation (FMT) infused into the small intestine of patients with PsA with active peripheral disease who are non-responsive to methotrexate (MTX) treatment will be conducted. The objective is to explore clinical aspects associated with FMT performed in patients with PsA. Methods and analysis This trial is a randomised, two-centre stratified, double-blind (patient, care provider and outcome assessor), placebo-controlled, parallel-group study. Eighty patients will be included and randomised (1:1) to either placebo (saline) or FMT provided from an anonymous healthy donor. Throughout the study, both groups will continue the weekly self-administered subcutaneous MTX treatment, remaining on the preinclusion dosage (15–25 mg/week). The clinical measures of psoriasis and PsA disease activity used include the Short (2-page) Health Assessment Questionnaire, the Dermatology Quality of Life Index, the Spondyloarthritis Research Consortium of Canada Enthesitis Index, the Psoriasis Area Severity Index, a dactylitis digit count, a swollen/tender joint count (66/68), plasma C reactive protein as well as visual analogue scales for pain, fatigue and patient and physician global assessments. The primary end point is the proportion of patients who experience treatment failure during the 6-month trial period. The number of adverse events will be registered throughout the study. Ethics and dissemination This is a proof-of-concept clinical trial and will be performed in agreement with Good Clinical Practice standards. Approvals have been obtained from the local Ethics Committee (DK-S-20150080) and the Danish Data Protection Agency (15/41684). The study has commenced in May 2017. Dissemination will be through presentations at national and international conferences and through publications in international peer-reviewed journal(s). Trial registration number NCT03058900 ; Pre-results.
    Keywords: Clinical trials (epidemiology), Open access, Rheumatology
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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