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  • 1
    Keywords: Bioavailability • Brassica vegetables • Cancer • Glucosinolates • Isothiocyanates
    Abstract: Glucosinolates (GLSs) are found in Brassica vegetables. Examples of these sources include cabbage, Brussels sprouts, broccoli, cauliflower and various root vegetables (e.g. radish and turnip). A number of epidemiological studies have identified an inverse association between consumption of these vegetables and the risk of colon and rectal cancer. Animal studies have shown changes in enzyme activities and DNA damage resulting from consumption of Brassica vegetables or isothiocyanates, the breakdown products (BDP) of GLSs in the body. Mechanistic studies have begun to identify the ways in which the compounds may exert their protective action but the relevance of these studies to protective effects in the human alimentary tract is as yet unproven. In vitro studies with a number of specific isothiocyanates have suggested mechanisms that might be the basis of their chemoprotective effects. The concentration and composition of the GLSs in different plants, but also within a plant (e.g. in the seeds, roots or leaves), can vary greatly and also changes during plant development. Furthermore, the effects of various factors in the supply chain of Brassica vegetables including breeding, cultivation, storage and processing on intake and bioavailability of GLSs are extensively discussed in this paper.
    Type of Publication: Journal article published
    PubMed ID: 19035553
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  65. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC); 20140511-20140514; Dresden; DOCMI.16.01 /20140513/
    Publication Date: 2014-05-14
    Keywords: amygdalohippocampectomy ; temporal infarction ; epilepsy outcome ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    ISSN: 1365-2958
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Transcriptional regulation of the deoP2 promoter by the cyclic AMP/cyclic AMP receptor protein complex (cAMP/CRP) and the CytR repressor requires two high-affinity CRP targets located around -41 and -93 bp preceding the start site for transcription. Here we report the structure of cddP, another CRP/CytR-regulated promoter. In common with what was found in deo, the cdd promoter also contains multiple CRP targets. Thus, using the DNasel footprinting procedure, tandem CRP binding sites were identified around -41 and -93. These findings support a general model for CytR binding and CytR regulation, in which (i) CytR and the CRP/cAMP complex bind to similar or Identical targets, (ii) two or more targets are necessary for proper binding of CytR to a promoter region, and (iii) CytR represses transcription by antagonizing cAMP/CRP activation.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 70 (1999), S. 2960-2967 
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Calculations of focal properties and third-order aberration coefficients are presented for atom mirrors based on elastically deformed single-crystal surfaces. Biaxial loading of the mirrors is achieved by a combination of a uniform applied pressure and rectangular boundary conditions. The results are calculated for readily available single-crystal wafers of Si(111) with a thickness of 50 μm and a usable free standing diameter of 18 mm. Focusing of beams at non-normal incidence requires the principal radii of curvature, in planes normal to the mirror plane, to be different. The ratio of these principal radii of curvature is shown to be insensitive to the applied pressure and can be varied by a factor greater than 10 by changing the boundary conditions from square (1:1) to rectangular (1:2). © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 64 ambulante Patienten mit eindeutiger Harnwegsinfektion erhielten zufallsgemäß entweder 250 mg Cefroxadin viermal täglich oder 500 mg Cephalexin viermal täglich über einen Zeitraum von zehn Tagen. Bevor die Patienten in die Therapiegruppen eingeteilt wurden und an den Tagen 0, 1, 3, 7 und 21 wurde der Urin kulturell getestet. Wegen nichtsignifikanter Bakteriurie am Tag 0 wurde bei 20 Patienten die Behandlung vorzeitig beendet. Beide Behandlungsschemata — wobei die Dosis von Cefroxadin nur die Hälfte der Cephalexindosis ausmachte — zeigten während der Behandlung gute Wirksamkeit; statistisch signifikante Unterschiede zwischen den beiden Medikamenten waren nicht nachzuweisen. In beiden Behandlungsgruppen waren bei der Kontrolluntersuchung mehrere Rezidive festzustellen. Nur bei drei Patienten der Cefroxadin-Gruppe wurden unerwünschte Nebenwirkungen des Medikamentes mitgeteilt, in der Cephalexin-Gruppe hingegen in keinem Fall.
    Notes: Summary A total of 64 out-patients with significant urinary tract infection were randomly allocated to treatment with cefroxadine 250 mg q.i.d. or cephalexin 500 mg q.i.d. for ten days. Urine cultures were performed before allocation to the treatment groups and on Days 0, 1, 3, 7 and 21. Twenty patients discontinued treatment prematurely because of insignificant bacteriuria on Day 0. Both drug regimes — the cefroxadine dose was half that of cephalexin — showed good activity during treatment, and no statistically significant differences were found between the two drugs. At follow-up, several relapses were found in both treatment groups. Adverse drug reactions were only reported by three patients in the cefroxadine group, and by none in the cephalexin group.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 6 (1999), S. 1554-1561 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Resistive magnetohydrodynamic spectra of toroidal plasmas are calculated using the recently developed Jacobi–Davidson eigenvalue solver. Poloidal mode coupling in finite aspect ratio tokamaks yields gaps in the ideal Alfvén continuous spectrum. If resistivity is included, the ideal continua disappear and are replaced by damped global waves located on specific curves in the complex frequency plane. The end points of these curves join the tips of the ideal continua and the boundaries of the ideal spectral gap. The eigenfunctions of the waves on these resistive curves are shown to have definite parity in the poloidal harmonics. It is shown that for very small toroidicity the topology of the resistive spectrum is completely different from the cylindrical one. Independent of the size of the inverse aspect ratio the ideal gap remains visible in the resistive spectrum. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Plasmas 7 (2000), S. 4208-4222 
    ISSN: 1089-7674
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The magnetohydrodynamic (MHD) spectra of toroidally rotating, axisymmetric tokamaks are analyzed. The continuous spectrum equations for the coupled localized Alfvén and slow modes are derived. The effect of flow on this spectrum is threefold: Doppler shift, centrifugal, and Coriolis effects enter. By exploiting a low-β, large aspect ratio expansion, the newly found low frequency Δm=0 Alfvén gap [van der Holst et al., Phys. Rev. Lett. 84, 2865 (2000)] located on the rational mode surfaces is analyzed. This gap is created by the geodesic curvature of the field lines, together with finite pressure, and by centrifugal and Coriolis effects. It is determined by a three mode interaction involving a central Alfvén mode and two sideband slow modes. From the same scheme, another new purely flow-induced gap inside the Δm=0 gap is found. Also, toroidal flow-induced Alfvén eigenmodes (TFAE) are found in the Δm=0 gap. All of these waves may be useful for MHD spectroscopy. Since the gap structures as well as the global wave are in the low frequency regime, they will have important implications for stability. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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