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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of neurocytology 29 (2000), S. 765-773 
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract NPC1 is a member of a family of polytopic membrane-bound proteins with sterol-sensing domains. Inactivating mutations of NPC1 are responsible for most cases of Niemann-Pick type C disease, whose hallmark is progressive neurodegeneration. The precise molecular mechanisms whereby defective NPC1 function leads to neurodegeneration are unknown. In the brain, we have previously found NPC1 to localize predominantly within perisynaptic astrocytic processes. Here we have mapped the regional distribution of NPC1 in the monkey brain. Dense NPC1 immunoreactivity was observed in telencephalic structures, including the cerebral neocortex, hippocampus, caudate nucleus and putamen, whilst light immunostaining was observed in diencephalic structures, including the globus pallidus, thalamus and hypothalamus. Light staining was also generally observed in the midbrain, pons, medulla oblongata and cerebellum, except the inferior olive, which was densely stained. By light microscopy, only a few indistinctly labeled cell bodies were observed even within densely labeled regions, where most of the immunoreactivity appeared to be due to the large numbers of labeled cellular processes. On electron microscopy, these processes were identified as glial, and not neuronal. The astrocytic localization of NPC1 was further confirmed by double labeling for NPC1 and GFAP. The regional pattern of NPC1 expression suggests that areas normally expressing low levels of the NPC1 protein are more susceptible to neuronal degeneration in Niemann-Pick type C disease.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 78 (2001), S. 204-206 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The electron spin resonance (ESR) is optically detected by monitoring the microwave-induced changes in the circular polarization of the neutral exciton (X) and the negatively charged exciton (X−) emission in CdTe quantum wells with low density of excess electrons. We find that the circular polarization of the X and X− emission is a mapping of the spin polarization of excess electrons. By analyzing the ESR-induced decrease in the circular polarization degree of the X emission, we deduce the microwave-induced electron spin-flip time 〉0.1 μs, which is much longer than the recombination time of X and X−. This demonstrates that the optically detected ESR in type I quantum wells with low density of excess electrons does not obey the prerequisite for the conventional optically detected magnetic resonance. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Metal-oxide-semiconductor (MOS) capacitance–voltage (C–V) characteristics in the accumulation mode have been measured and simulated for polycrystalline Si gate MOS capacitors with various oxide thicknesses (40–200 A(ring)) on p-type (100) Si substrates. The discrepancy between experimental data and theoretical prediction by classical MOS theories is clarified by taking quantization effects into account. The experimentally determined "effective dielectric thicknesses'' in the semiconductors are found to be in good agreement with the values calculated from quantization effects for MOS capacitors with thinner oxides (〈80 A(ring)). The effective dielectric thicknesses at oxide electric fields of 2–6 MV/cm have been determined to be 2–3 A(ring) larger for the quantum mechanical case than for the classical case.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Properties ofR-matrix theory that are useful for studying muon-catalyzed fusion reactions are reviewed, and applications to the dtμ system are discussed, using both “improved adiabatic” and non-adiabatic (variational) wave functions. We give complex eigenvalues and α-μ sticking fractions for the (L, v)=(0,0) and (0, 1) states of dtμ using variational Hamiltonian matrix elements that have been properly symmetrized by means of the Block operator. Expressions for the fusion rate and α-μ sticking fraction are developed from a time-dependent theory that uses the complex-energy states corresponding to the poles of the systemS-matrix. These are shown to reduce with the appropriate approximations to the expressions and values commonly used. Additional nuclear effects on these quantities can easily be studied within the framework developed, but they are not expected to be large.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2242
    Keywords: Embryo rescue ; Glycine spp. ; Intersubgeneric hybrids ; Soybean ; Wide hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Employing a different culture strategy, we obtained a greatly improved frequency of embryo rescue in intersubgeneric soybean hybrids. Successful crosses were obtained in 31 different genotype combinations between nine Brazilian soybean lines as the female parents and 12 accessions from Glycine canescens, G. microphylla, G. tabacina and G. tomentella. The hybrid pod retention rate dropped to about 10% during the first 8 days after pollination and stayed largely unchanged up to the 20th day. Immature harvested seeds fell into three size groups: Group 1, smaller than 1.3 mm (mostly empty seed coats); Group 2, 1.9–5.0 mm; Group 3, larger than 5 mm (from selfing). A total of 90 putative hybrid embryos were rescued using a highly enriched B5 medium to nourish the newly dissected embryos. The growing embryos were then placed in a high osmotic, modified B5 medium to induce maturation and dormancy. Schenk and Hildebrandt medium was used to germinate the dormant, partially dehydrated, physiologically mature embryos. Approximately 37% of the rescued embryos developed into plantlets in vitro, and approximately 8% grew into mature plants in the greenhouse. Morphological, cytological and isoenzyme patterns confirmed the hybrid status of all seven mature plants, all of which were generated using G. tomentella G 9943 as the paternal parent. It was observed that all soybean lines crossed with G 9943 were capable of producing mature hybrid plants. There was no correlation between the initial size of Group 2 seeds and plant survival rate. The hybrids were cloned by grafting and treated with colchicine. One of the treated plants displayed chromosome doubling.
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  • 7
    ISSN: 0730-2312
    Keywords: monoclonal antibody ; ELISA ; adipocyte plasma membranes ; SDS-PAGE ; protein composition ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: A monoclonal antibody (LA-1) to an adipocyte-specific plasma membrane protein (64 kD) was used to examine the differential expression of this protein in genetically lean and genetically obese pigs. Enzyme-linked immunosorbent assay (ELISA) implied the differential expression of the 64 kD protein in adipocyte plasma membranes having different genetic background. Sodium dodecyl-sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of genetically lean, genetically obese, and contemporary subcutaneous adipocyte plasma membranes did not indicate any obvious qualitative differences in protein composition. Corresponding immunoblots utilizing LA-1 confirmed the presence of the 64 kD protein in contemporary and genetically lean adipocyte plasma membranes but absence in genetically obese adipocyte plasma membranes. LA-1 labelled intact adipocytes isolated from contemporary and genetically lean adipose tissue but did not react with isolated genetically obese adipocytes. The ability to bind to intact adipocytes indicates that the protein is exposed to the extracellular environment. The migration pattern of the protein was not affected by enzymatic deglycosylation by endoglycosidase-F suggesting that the protein is not highly, if at all, glycosylated. Presence of the 64 kD protein in genetically lean but not genetically obese adipocyte plasma membranes indicates the identification of a novel adipocyte-specific surface protein associated, either directly or secondary to the onset of obesity, with genetic predispositions for either genetically lean or obese body types in swine.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 18 (1976), S. 1557-1572 
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Tower cycling fermentors for the production of single-cell protein from volatile substrates were studied. The mass transfer, mixing and circulation patterns, and residence time distribution (RTD) curves were investigated in these vessels. This study suggests that the tower cycling fermentors for volatile substrates fermentation may improve product yields and at the same time reduce the power consumption, thereby resulting in a significant increase in operating cost savings and capital profits. The results of this research further indicate a future potential for commercial scale tower cycling fermentors.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Analytica Chimica Acta 295 (1994), S. 127-134 
    ISSN: 0003-2670
    Keywords: Computer perception ; Expert systems ; Structure elucidation ; Topological symmetry
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Nuclear Physics 66 (1965), S. 449-464 
    ISSN: 0029-5582
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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