Springer Online Journal Archives 1860-2000
Abstract Cultured embryonic cells from Rattus (Mastomys) natalensis were treated with the base analogues 5-bromodeoxyuridine and 2-aminopurine, the viruses herpes simplex virus and adenovirus type 12, and the carcinogens 7,12-dimethylbenz(a)anthracene and urethan. Treatment with these agents, except urethan, causes an increase in the incidence of chromosome aberrations. The induced aberrations are not randomly distributed among the chromosomes or within a chromosome. The X chromosome, especially its long arm, is more sensitive to these agents than is any other chromosomes in the complement. — A possible relationship among the high incidence of damage, the positive heteropycnosis, and the late replication in the X chromosome of R. natalensis is discussed.
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