Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: RECEPTOR ; tumor ; carcinoma ; CELL ; Germany ; LUNG ; THERAPY ; CT ; DIAGNOSIS ; LUNG-CANCER ; DISEASE ; HISTORY ; liver ; PATIENT ; primary ; prognosis ; tumour ; LYMPH-NODES ; 5-FLUOROURACIL ; NO ; NEOPLASIA ; MALIGNANCIES ; METASTASIS ; metastases ; chemotherapy ; INVOLVEMENT ; SCINTIGRAPHY ; LIVER METASTASES ; SOMATOSTATIN ; POOR-PROGNOSIS ; pancreatic carcinoma ; ETOPOSIDE ; CELL CARCINOMA ; MALIGNANCY ; ENDOCRINE ; EXTRAPULMONARY ; GEMCITABINE ; NODES ; OF-THE-LITERATURE ; pancreas ; review ; small cell carcinoma ; somatostatin-analogue ; UNDIFFERENTIATED CARCINOMA
    Abstract: Small cell carcinoma (SCC) of the pancreas is a rare malignancy with an extremely poor prognosis. We present the case of a 74-year-old man with a 2-month history of upper abdominal discomfort who was diagnosed with SCC of the pancreas tail, involvement of peripancreatic and mesenteric lymph nodes and multiple liver metastases ( extended disease). A CT scan and a positive somatostatin receptor scintigraphy showed no evidence of a primary lung tumour. The diagnosis of a SCC was confirmed by biopsy. Local tumour control could be achieved by gemcitabine once a week and a long-acting somatostatin analogue once a month, but liver metastasis showed progress. Thus, 5-fluorouracil on a weekly basis was started. The patient died 8 months after diagnosis and had not been hospitalised in the meantime. Copyright (C) 2004 S. Karger AG, Basel and IAP
    Type of Publication: Journal article published
    PubMed ID: 15334003
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: ANGIOGENESIS ; CANCER ; CELLS ; ENDOTHELIAL-CELLS ; EXPRESSION ; TUMOR-CELLS ; carcinoma ; Germany ; human ; SYSTEM ; PROTEIN ; DIFFERENTIATION ; TISSUE ; LINES ; PATIENT ; ACTIVATION ; COMPLEX ; COMPLEXES ; MARKER ; TISSUES ; CELL-LINES ; PLASMA ; COLORECTAL-CANCER ; CELL-LINE ; LINE ; TISSUE FACTOR ; adenocarcinoma ; cell lines ; pancreatic cancer ; pancreatic carcinoma ; chronic pancreatitis ; PANCREATIC-CANCER ; THROMBOSIS ; LEVEL ; pancreatic ; EXTRACELLULAR-MATRIX PROTEINS ; FRAGMENT ; PULMONARY-EMBOLISM ; CLINICAL COURSE ; coagulation activation ; HUMAN DUCTAL ADENOCARCINOMAS ; NORTHERN ; thromboembolism ; VENOUS THROMBOEMBOLISM
    Abstract: AIM: To study expression of tissue factor (TF) in pancreatic cancer and its role in the development of thromboembolism. METHODS: TF expression was studied in eight human pancreatic carcinoma cell lines by Northern blot and indirect immunofluorescence. Expression of alternatively spliced TF (asTF) was assessed by RTPCR. In addition, TF expression was determined by immunofluorescence in pancreatic tissues of 19 patients with pancreatic adenocarcinoma (PCa), 9 patients with chronic pancreatitis (CP) and 20 normal controls. Plasma samples (30 PCa-patients, 13 CP-patients and 20 controls) were investigated for soluble TF levels and coagulation activation markers [thrombin-antithrombin III complex (TAT), prothrombin fragment 1 + 2 (F1 + 2)]. RESULTS: All pancreatic carcinoma cell lines expressed TF (8/8) and most of them expressed asTF (6/8). TF expression at the protein level did not correlate with the differentiation of the carcinoma cell line. All but two pancreatic cancer tissue samples stained positive for TF (17/19). In all samples of CP weak staining was restricted to pancreatic duct cells, whereas only a few subendothelial cells were positive in 9/20 of normal controls. TF and TAT levels in PCa patients were significantly elevated compared to controls whereas elevated F1 + 2 levels did not reach statistical significance compared to controls. In CP patients TAT and F1 + 2 levels proved to be significantly elevated compared to controls, although TAT elevation was less pronounced than in PCa patients. CONCLUSION: We conclude that in addition to the upregulated expression of TF on the cell membrane, soluble TF might contribute to activation of the coagulation system in pancreatic cancer. (C) 2006 The WJG Press. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 16937466
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    Keywords: EXPRESSION ; SYSTEM ; GENOME ; NF-KAPPA-B ; ACTIVATION ; INDUCTION ; T-CELLS ; GENE-REGULATION ; STERNBERG CELLS ; FACTOR-BINDING
    Abstract: Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific accessible chromatin by global mapping of DNaseI hypersensitive sites and analyzed enriched TF-binding motifs in these regions. Applying this unbiased approach to classical Hodgkin lymphoma (HL), a common B-cell-derived lymphoma with a complex pattern of deregulated TFs, we discovered interferon regulatory factor (IRF) sites among the top enriched motifs. High-level expression of the proinflammatory TF IRF5 was specific to HL cells and crucial for their survival. Furthermore, IRF5 initiated a regulatory cascade in human non-Hodgkin B-cell lines and primary murine B cells by inducing the TF AP-1 and cooperating with NF-kappaB to activate essential characteristic features of HL. Our strategy efficiently identified a lymphoma type-specific key regulator and uncovered a tumor promoting role of IRF5.
    Type of Publication: Journal article published
    PubMed ID: 25288773
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    Abstract: Apart from its unique histopathological appearance with rare tumor cells embedded in an inflammatory background of bystander cells, classical Hodgkin lymphoma (cHL) is characterized by an unusual activation of a broad range of signaling pathways involved in cellular activation. This includes constitutive high-level activity of nuclear factor-kappaB (NF-kappaB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), activator protein-1 (AP-1) and interferon regulatory factor (IRF) transcription factors (TFs) that are physiologically only transiently activated. Here, we demonstrate that inactivation of the putative ubiquitin E3-ligase PDLIM2 contributes to this TF activation. PDLIM2 expression is lost at the mRNA and protein levels in the majority of cHL cell lines and Hodgkin and Reed-Sternberg (HRS) cells of nearly all cHL primary samples. This loss is associated with PDLIM2 genomic alterations, promoter methylation and altered splicing. Reconstitution of PDLIM2 in HRS cell lines inhibits proliferation, blocks NF-kappaB transcriptional activity and contributes to cHL-specific gene expression. In non-Hodgkin B-cell lines, small interfering RNA-mediated PDLIM2 knockdown results in superactivation of TFs NF-kappaB and AP-1 following phorbol 12-myristate 13-acetate (PMA) stimulation. Furthermore, expression of PDLIM2 is lost in anaplastic large cell lymphoma (ALCL) that shares key biological aspects with cHL. We conclude that inactivation of PDLIM2 is a recurrent finding in cHL and ALCL, promotes activation of inflammatory signaling pathways and thereby contributes to their pathogenesis.
    Type of Publication: Journal article published
    PubMed ID: 27538486
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Keywords: CELLS ; EXPRESSION ; proliferation ; SURVIVAL ; CELL ; Germany ; KINASE ; screening ; SYSTEM ; GENE ; GENES ; transcription ; cell line ; LINES ; NF-KAPPA-B ; ACTIVATION ; COMPLEX ; COMPLEXES ; TRANSCRIPTION FACTOR ; T-CELL ; CELL-LINES ; TRANSGENIC MICE ; LESIONS ; LYMPHOMA ; REED-STERNBERG CELLS ; NUMBER ; CELL-LINE ; LINE ; PATHOGENESIS ; FACTOR-KAPPA-B ; CONSTITUTIVE ACTIVATION ; KAPPA-B ; OVEREXPRESSION ; cell lines ; COMPLEX-FORMATION ; ABSENCE ; molecular ; INCREASE ; TARGET GENE ; TARGET GENES ; NUCLEAR ; LOCUS ; LYMPHOMAS ; T-NHL ; IKK ; anaplastic ; HODGKIN-LYMPHOMA ; function ; ALCL ; LARGE-CELL LYMPHOMA ; CANDIDATE PROTOONCOGENE BCL-3 ; DISEASE TUMOR-CELLS ; ONCOPROTEIN BCL-3 ; P50 HOMODIMERS ; classical Hodgkin lymphoma
    Abstract: Transcription factor nuclear factor kappa B (NF-kappaB) plays a central role in the pathogenesis of classical Hodgkin lymphoma (cHL). In anaplastic large-cell lymphomas (ALCLs), which share molecular lesions with cHL, the NF-kappaB system has not been equivalently investigated. Here we describe constitutive NF-kappaB p50 homodimer [(p50)2] activity in ALCL cells in the absence of constitutive activation of the IkappaB kinase (IKK) complex. Furthermore, (p50)2 contributes to the NF-kappaB activity in Hodgkin/Reed-Sternberg (HRS) cells. Bcl-3, which is an inducer of nuclear (p50)2 and is associated with (p50)2 in ALCL and HRS cell lines, is abundantly expressed in ALCL and HRS cells. Notably, a selective overexpression of Bcl-3 target genes is found in ALCL cells. By immunohistochemical screening of 288 lymphoma cases, a strong Bcl-3 expression in cHL and in peripheral T-cell non-Hodgkin lymphoma (T-NHL) including ALCL was found. In 3 of 6 HRS cell lines and 25% of primary ALCL, a copy number increase of the BCL3 gene locus was identified. Together, these data suggest that elevated Bcl-3 expression has an important function in cHL and peripheral T-NHL, in particular ALCL.
    Type of Publication: Journal article published
    PubMed ID: 16123212
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    Keywords: CANCER ; IRRADIATION ; Germany ; imaging ; DISEASE ; HISTORY ; DRUG ; SURGERY ; PATIENT ; treatment ; COMPUTED-TOMOGRAPHY ; ABNORMALITIES ; ANGIOGRAPHY ; SMALL-INTESTINE ; COMPLICATIONS ; INFLAMMATORY-BOWEL-DISEASE ; STENOSIS ; technique ; PUSH-ENTEROSCOPY ; DRUGS ; ENDOSCOPY ; BOWEL ; Crohn disease ; gastrointestinal bleeding ; jejunal stenosis ; wireless capsule enteroscopy
    Abstract: Wireless capsule enteroscopy, being a novel, painless investigative technique, is reported to be significantly superior to push enteroscopy in its ability to find bleeding abnormalities in the small intestine. Here we report a case of acute jejunal obstruction following wireless capsule endoscopy. The patient had a 1-month history of gastrointestinal bleeding of unknown source. Further evaluation including gastroscopy and colonoscopy, angiography and computed tomography (angio-CT), and radio-labeled erythrocytes scan failed to reveal a source of bleeding. Therefore, wireless capsule enteroscopy was performed. Before capsule endoscopy, there was no clinical or imaging evidence of strictures or stenosis. At readmission it could be shown that there were two inflamed strictures of the small intestine. The capsule was detected at a stricture of the small intestine detected by abdominal ultrasonography and conventional computed tomography. The patient underwent a medical treatment with steroidal and other anti-inflammatory drugs for a total of 23 days and was discharged without complaints. Acute laparotomy after readmission with jejunal ileus proofed the capsule occluding two highly inflamed jejunal stenosis caused by Crohn disease. The present case demonstrates the potential for complications when wireless capsule enteroscopy is performed in the presence of intestinal strictures. Any history of inflammatory bowel disease, abdominal irradiation, cancer, obstruction, and abdominal surgery must be elicited in detail and may exclude the use of wireless capsule enteroscopy
    Type of Publication: Journal article published
    PubMed ID: 16411112
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    Keywords: COMBINATION ; evaluation ; Germany ; VOLUME ; DISEASE ; TIME ; PATIENT ; IMPACT ; QUALITY ; NO ; FEASIBILITY ; prospective studies ; small bowel ; methods ; capsule endoscopy ; YIELD ; prospective ; prospective study ; PEOPLE ; WORLD ; China ; DOUBLE-BALLOON ENTEROSCOPY ; ELECTROLYTE ; laxative ; preparation ; PULL ENTEROSCOPY ; TRANSIT ; transit time ; visibility
    Abstract: AIM: To determine the effect of Prepacol (R), a combination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol (R) accelerated small bowel transit time (262 55 min vs 287 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol (R) has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. (c) 2008 WJG. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 18395907
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 72 (1950), S. 5318-5319 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...