Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; BLOOD ; COMMON ; COHORT ; RISK ; GENE ; TIME ; MARKER ; primary ; GENETIC POLYMORPHISMS ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; single nucleotide polymorphism ; ACID ; NO ; HEALTH ; PLASMA ; AGE ; etiology ; cancer risk ; case-control studies ; European Prospective Investigation into Cancer and Nutrition ; GASTRIC-CANCER ; nutrition ; STOMACH-CANCER ; SINGLE ; DEFICIENCY ; ONCOLOGY ; case control study ; case-control study ; REGRESSION ; ASSOCIATIONS ; VARIANT ; INCREASE ; SINGLE NUCLEOTIDE POLYMORPHISMS ; prospective studies ; gastric cancer ; METHYLENETETRAHYDROFOLATE REDUCTASE ; MTHFR ; LEVEL ; biomarker ; case control studies ; HELICOBACTER-PYLORI INFECTION ; GENOTYPE ; LOCUS ; single-nucleotide ; USA ; C677T POLYMORPHISM ; prospective ; prospective study ; INCREASED RISK ; odds ratio ; cancer research ; CANCER-RISK ; CHINESE POPULATION ; nested case-control study ; case control ; LOGISTIC-REGRESSION ; MENDELIAN RANDOMIZATION ; PLASMA-CONCENTRATION ; chronic atrophic gastritis ; gastric ; pepsinogen ; MTHFR POLYMORPHISMS ; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE ; EPIC-EURGAST ; MICROBIOLOGICAL ASSAY
    Abstract: Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Our nested case-control study within the European Prospective Investigation into Cancer and Nutrition cohort is the first prospective study of blood folate levels and gastric cancer. Gastric cancer cases (n = 247) and controls (n = 631) were matched for study center, age, sex, and time of blood donation. Two common single nucleotide polymorphisms of the MTHFR gene were determined, as were plasma concentrations of folate, cobalamin (vitamin B12), total homocysteine, and methylmalonic acid (cobalamin deficiency marker) in prediagnostic plasma. Risk measures were calculated with conditional logistic regression. Although no relations were observed between plasma folate or total homocysteine concentrations and gastric cancer, we observed a trend toward lower risk of gastric cancer with increasing cobalamin concentrations (odds ratio, 0.79 per SD increase in cobalamin; P = 0.01). Further analyses showed that the inverse association between cobalamin and gastric cancer was confined to cancer cases with low pepsinogen A levels (marker of severe chronic atrophic gastritis) at the time of blood sampling. The 677 C -〉 T MTHFR polymorphism was not associated with gastric cancer, but we observed an increased risk with the variant genotype of the 1298 A -〉 C polymorphism (odds ratio, 1.47 for CC versus AA; P = 0.04). In conclusion, we found no evidence of a role of folate in gastric cancer etiology. However, we observed increased gastric cancer risk at low cobalamin levels that was most likely due to compromised cobalamin status in atrophic gastritis preceding gastric cancer
    Type of Publication: Journal article published
    PubMed ID: 18006931
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: CANCER ; COHORT ; RISK ; IMPACT ; CARCINOGENESIS ; BIOMARKERS ; ASSOCIATION ; polymorphism ; POLYMORPHISMS ; VARIANTS ; HEALTH ; PLASMA ; AGE ; colorectal cancer ; smoking ; COLORECTAL-CANCER ; FIBER ; COLON-CANCER ; MASS-SPECTROMETRY ; EPIC ; nutrition ; education ; NESTED CASE-CONTROL ; physical activity ; ONCOLOGY ; case-control study ; REGRESSION ; ASSOCIATIONS ; VARIANT ; PHYSICAL-ACTIVITY ; biomarker ; methods ; dietary patterns ; GENOTYPE ; LOCUS ; prospective ; CANCER-RISK ; nested case-control study ; COMMON MUTATION ; MTHFR POLYMORPHISMS ; FOLIC-ACID ; Genetic ; FOLATE STATUS ; METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM ; nested case control study ; C677T MTHFR POLYMORPHISM ; CARBON METABOLIC PATHWAY ; HUMAN METHIONINE SYNTHASE
    Abstract: Background: A potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort. Methods: In this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber. Results: Overall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; P-trend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C -〉 T, MTHFR1298A -〉 C, MTR2756A -〉 G, MTRR66A -〉 G, and MTHFD11958G -〉 A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; P-trend) TT versus CC = 1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC = 0.74 (0.39-1.37); 0.34]. The SLC19A180G -〉 A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59); 〈0.01]. Conclusions: This large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms. Impact: Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions. Cancer Epidemiol Biomarkers Prev; 19(5); 1328-40. (C)2010 AACR
    Type of Publication: Journal article published
    PubMed ID: 20447924
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...