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  • 1
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Chromosomal studies were carried out in bone marrow and testes of mice treated with lysergic acid diethylamide (LSD-25) in acute and chronic experiments, in blood cultures of rhesus monkeys (Macaca mulatta) treated with LSD-25 in vitro, and in blood cultures and testicular preparations of rhesus macaques treated with LSD. No increase in chromosomal damage was observed in bone marrow or testes, but all blood cultures treated with LSD in vitro and some of the blood cultures from rhesus macaques treated in vitro showed a significant increase in chromosomal breaks and rearrangements.
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  • 2
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 204 (1964), S. 189-190 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Recently, a series of benzomorphans with narcotic antagonist activity7 also has been shown to possess potent clinical analgesic efficacy8'9. These compounds, too, were found inactive in several animal analgesic tests7. One of them, cyclazocine, was shown to increase the aversive shock threshold of ...
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  • 3
    ISSN: 1432-2072
    Keywords: Long-Acting Perphenazine ; Long-Acting Fluphenazine ; Conditioned Avoidance Behavior ; Locomotor Treadwheel Activity ; Phenothiazines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The enanthate ester of perphenazine, when administered subcutaneously in oil, but not in aqueous solution or suspension, exerted significant conditioned avoidance and locomotor depression in the rat for a substantially longer time than either equipotent or equimolar doses of its free base. The effects were still observable 18–21 days after a single injection of the ester. 2. The prolonged action of perphenazine enanthate probably can be attributed to a combination of a tissue oil-depot and hydrolysis of the ester to form the free base. 3. Perphenazine enanthate possesses approximately one-third the mg potency of fluphenazine enanthate. In equivalent behavioral dosage, however, perphenazine enanthate exhibits a duration of action equal to that of fluphenazine enanthate. 4. Increasing the dose had little additive effect in terms of duration of activity which suggests that lower doses, which presumably could dimmish the incidence of untoward side effects, might be used without significantly diminishing the intensity or duration of therapeutic activity.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 12 (1968), S. 286-302 
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 5
    ISSN: 1432-2072
    Keywords: Mouse ; Animal Behavior ; Observational Measurement ; Drugs ; Biological Assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A systematic observational method is described for comprehensively assessing and quantifying the behavioral and physiologic state of the mouse and its response to drugs. With this method, the pattern profile of various classes of pharmacologic agents and their members can be identified and differentiated, and the relative specificity of their actions defined. The method is applicable to a wide range of investigative goals. Inter- and intra-observer reliability studies have shown it to meet the pragmatic requirements for research.
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  • 6
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A conceptual framework for psychopharmacology is presented to guide experimentation, new drug development, pre-clinical drug evaluation, and the therapeutic selection and use of psychiatric drugs. The more important considerations for pre-clinical evaluation are analyzed and discussed, what constitutes an adequate animal assessment, and phenothiazine-like tranquilizers are used to illustrate the process of new drug development and evaluation. Discussed are the predictions required from animals to man, and the nature and range of information and methodological approaches required to achieve this. Stressed are the importance of systematic multidimension observational procedures, information on minimal dose effects rather than ED 50's, and on acquiring information of therapeutic relevance. The therapeutic effects of phenothiazines in man are reviewed, areas for drug improvement defined, and attention directed to procedures for testing agents of this type. Also reviewed are drug affects in animals predictive of anti-psychotic activity, extrapyramidal stimulation, sedative-hypnotic, and a variety of other effects for man.
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  • 7
    ISSN: 1432-2072
    Keywords: Foot Shock ; Mouse ; Distress Arousal ; Fighting ; Locomotor Activity ; Vocalizing ; Recovery Time ; Imipramine ; Methamphetamine ; Perphenazine ; Methadone ; Pentobarbital ; Ethyl Alcohol ; Chlordiazepoxide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Methodologic studies were undertaken to establish the optimal conditions of continuous foot shock stimulation (3 min at 0.08 mA) for investigating drug effects on distress-evoked behavior, e.g., vocalizing, leaping, running, fighting and recovery latencies. The drugs subsequently studied under these conditions (imipramine, methamphetamine, methadone, perphenazine, pentobarbital, ethyl alcohol and chlordiazepoxide) could be distinguished and classified from the profiles of action obtained. Greatest overall reduction of the distress-evoked behaviors in diminishing order were produced by perphenazine, methadone, ethyl alcohol and chlordiazepoxide. Methadone most selectively reduced leaping responses; perphenazine most selectively prolonged recovery time latencies. None of the agents reduced fighting at doses that did not also modify the other modes of responding.
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