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  • 1
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  • 3
    Online Resource
    Online Resource
    Dordrecht : : Springer Science+Business Media,
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9789048132713
    Series Statement: Advances in experimental medicine and biology,
    Language: English
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  • 4
    Online Resource
    Online Resource
    Dordrecht : : Springer Netherlands,
    In: Springer eBooks
    Type of Medium: Online Resource
    ISBN: 9789400728882
    Series Statement: Advances in experimental medicine and biology,
    Language: English
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  • 5
    Online Resource
    Online Resource
    Dordrecht : : Springer Netherlands, | Dordrecht : : Springer Netherlands :
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: XXXI, 1415 p. 170 illus., 113 illus. in color. eReference. , online resource.
    Edition: 2nd ed. 2015.
    ISBN: 9789400766860
    Language: English
    Note: Microscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of ��-Cell Failure -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in ��-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Exocytosis in Islet ��-Cells -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Mechanisms of Pancreatic ��-Cell Apoptosis in Diabetes and Its Therapies -- ��-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The ��-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve ��-Cell Function in Diabetes -- Immunology of ��-Cell Destruction -- Prevention of ��-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote -- Successes and Disappointments with Clinical Islet Transplantation -- Exercise-induced pancreatic islets adaptations in health and disease -- Role Reg family proteins on islet cell growth and survival -- Circadian control of islet function -- Zinc Transporters in the pancreas -- Making Islets from Human Embryonic Stem Cells -- Chloride channels and Transporters in ��-cell physiology -- Pancreatic beta cells in metabolic syndrome -- Insulin and IGF-1 receptor signalling in insulin secreting cells -- Beta cell store-operated ion channels -- Isolation of Rodent Islets of Langerhans -- Anionic Transporters� and Channels in Pancreatic Islet Cells -- Glucose-Induced Apoptosis in Pancreatics Islets -- In Vivo Biomarkers for Detection of Beta Cell Death -- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes -- Islet Encapsulation -- Islet Isolation for Autotransplantation -- Islet Xenotransplantation: recent advances and future prospects -- Molecular basis of cAMP signaling in pancreatic beta cells -- NADPH Oxidase in Beta Cell Dysfunction -- Pancreatic Neuroendocrine Tumors -- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells -- Reproductive Hormones and Islet Adaptation to Metabolic Stress -- Stem Cells in Pancreatic Islets -- Transcriptional co-Activators in Beta-Cell Function and Disease Pathology.
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  • 6
    In: Springer Nature eBook
    Description / Table of Contents: This volume details the fundamentals of the CRISPR-Cas system, and its protocols illustrate advances in CRISPR-Cas techniques for efficient genome editing. Introductory chapters provide a wide horizon of CRISPR/Cas-based methods and applications. Additional chapters guide readers through HDR-mediated editing, sgRNA design, the step-by-step procedure of multiplex adenine base editing experiments in rice, generating mutants for rice, wheat, Brachypodium, Barley, Flax, and Phytophthora, visual screening of mutants, gene deletion (knock-out), tagging (knock-in) in mammalian cells, the cloning-free (DNA-free) technique, cell-penetrating peptides, generating a genome-edited banana, and nuclear genome editing of Chlamydomonas employing CRISPR-Cpf1 combined with a single-stranded DNA (ssODN) repair template. Authoritative and cutting-edge, CRISPR-Cas Methods aims to assist researchers who are new to the field and are aiming to learn how best to adopt this technology for a particular organism.
    Type of Medium: Online Resource
    Pages: XIV, 278 p. 67 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9781071606162
    Series Statement: Springer Protocols Handbooks,
    Language: English
    Note: 1. Efficient Homologous Recombination Mediated in Planta Gene Targeting by Egg-cell Specific Expression of Staphylococcus aureus Cas9 from Arabidopsis -- 2. Rice gene knockout or down regulation through CRISPR-Cas9 -- 3. Simultaneous CRISPR/Cas-mediated Single Base Editing in Rice Plant at More than One Locus -- 4. CRISPR-Cas9 Mediated Genome Editing of the Model Grass Species Brachypodium distachyon -- 5. CRISPR/Cas9-mediated Gene Editing of the Plant Pathogenic Oomycete Phytophthora palmivora -- 6. An effective CRISPR/Cas9 technology for efficiently isolating positive transformants and transgene-free mutants in a wide range of plant species -- 7. An optimized RNA-guided Cas9 system for efficient simplex and multiplex genome editing in barley -- 8. Genome editing of mammalian cells using CRISPR/Cas: From in silico designing to in-culture validation -- 9. Cloning free (DNA-free) CRISPR/Cas9-mediated gene knockout in human liver cell line and its detection -- 10. A procedure to design guide RNA, assembly fragments, and detect mutation for genome editing in flax -- 11. Delivery of Cas9/sgRNA RNP into wheat microspores using synthetic CPP for genome editing and gene expression modulation -- 12. CRISPR- Cas9 mediated gene editing in wheat: a step by step protocol -- 13. CRISPR-Cas9 based genome editing of banana -- 14. Homology-directed transgene-free gene editing in Chlamydomonas reinhardtii.
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  • 7
    Online Resource
    Online Resource
    Dordrecht : : Springer Science+Business Media B.V.,
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: digital
    ISBN: 9789400702653
    Series Statement: Advances in experimental medicine and biology,
    Language: English
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  • 8
    Online Resource
    Online Resource
    Dordrecht : : Springer, | Dordrecht : : Springer Netherlands :
    In: Springer Nature Living Reference
    Description / Table of Contents: This book contains critical background information, and recent advances made in essentially all areas of islet research. It is a major reference book, the first of its kind, for islet researchers, and diabetes researchers. Anybody, including the experts, and the beginners, interested in the study of islet physiology, and diabetes, will find this book extremely useful. The book is robust in its breadth: it deals with anatomy, histology, ultra-structure, evolution and comparative anatomy, imaging, developmental biology, programming, apoptosis, mitochondrial function, metabolism, cellular signaling, electrophysiology, oscillation of hormone secretion, islets of model animals, immunology, proteomics, regenerative medicine, clinical advances, and islet transplantation. Individual chapters contributed by a large number of experts and enthusiasts, not only provide a balanced view of the recent advances made in the respective fields, but also provide directions and thoughts for future research. Thanks to vivid and colorful illustrations, tables and sketches, the book as a whole, and the individual chapters make reading a pleasant experience. If you are interested in diabetes research, you will love to have a personal copy of this book.
    Type of Medium: Online Resource
    Pages: 800 p. 240 illus., 200 illus. in color. , online resource.
    ISBN: 9789400768840
    Language: English
    Note: Microscopic Anatomy of the Human Islet of Langerhans -- The Comparative Anatomy of Islets -- Approaches for Imaging Islets: Recent Advances and Future Prospects -- Islet Cell Development -- High Fat Programming of β-Cell Failure -- Electrophysiology of Islet Cells -- ATP-Sensitive Potassium Channels in Health and Disease -- Role of Mitochondria in β-cell Function and Dysfunction -- Basement Membrane in Pancreatic Islet Function -- Calcium Signaling in the Islets -- Electrical Bursting, Calcium Oscillations, and Synchronization of Pancreatic Islets -- Exocytosis in Islet β-Cells -- Proteomics and Islet Research -- Wnt Signaling in Pancreatic Islets -- Mechanisms of Pancreatic β-Cell Apoptosis in Diabetes and Its Therapies -- β-Cell Function in Obese-Hyperglycemic Mice [ob/ob Mice] -- Islet Structure and Function in the GK Rat -- The β-Cell in Human Type 2 Diabetes -- Clinical Approaches to Preserve β-Cell Function in Diabetes -- Immunology of β-Cell Destruction -- Prevention of β-Cell Destruction in Autoimmune Diabetes: Current Approaches and Future Prospects -- Islet Isolation for Clinical Transplantation -- Human Islet Autotransplantation: The Trail Thus Far and the Highway Ahead -- Modulation of Early Inflammatory Reactions to Promote -- Successes and Disappointments with Clinical Islet Transplantation -- Exercise-induced pancreatic islets adaptations in health and disease -- Role Reg family proteins on islet cell growth and survival -- Circadian control of islet function -- Zinc Transporters in the pancreas -- Making Islets from Human Embryonic Stem Cells -- Chloride channels and Transporters in �-cell physiology -- Pancreatic beta cells in metabolic syndrome -- Insulin and IGF-1 receptor signalling in insulin secreting cells -- Beta cell store-operated ion channels -- Isolation of Rodent Islets of Langerhans -- Anionic Transporters and Channels in Pancreatic Islet Cells -- Glucose-Induced Apoptosis in Pancreatics Islets -- In Vivo Biomarkers for Detection of Beta Cell Death -- Inflammatory Pathways Linked to Beta Cell Demise in Diabetes -- Islet Encapsulation -- Islet Isolation for Autotransplantation -- Islet Xenotransplantation: recent advances and future prospects -- Molecular basis of cAMP signaling in pancreatic beta cells -- NADPH Oxidase in Beta Cell Dysfunction -- Pancreatic Neuroendocrine Tumors -- Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic Alpha-Cells -- Reproductive Hormones and Islet Adaptation to Metabolic Stress -- Stem Cells in Pancreatic Islets -- Transcriptional co-Activators in Beta-Cell Function and Disease Pathology.
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  • 9
    Online Resource
    Online Resource
    Cham : : Springer International Publishing | Cham : : Springer International Publishing :
    In: Springer eBooks
    Type of Medium: Online Resource
    Pages: XVI, 416 p. 53 illus., 4 illus. in color. , online resource.
    ISBN: 9783319444093
    Language: English
    Note: 1. Role of Bacillus genus in the production of value added compounds -- 2. Bacillus: as bioremediator agent of major environmental pollutants -- 3. Growth Promotion of Non-legumes by the Inoculation of Bacillus species -- 4. Management of the Western Corn Rootworm, Diabrotica virgifera virgifera LeConte, Using Transgenic Bt Maize -- 5. The efficiency of Bacillus species as PGPR and biocontrol agent under adverse environmental conditions -- 6. Contribution of Bacillus thuringiensis subsp. israelensis in biological control by its mosquitocidal activity against diptera -- 7. Bacillus spp., a promising biocontrol agent of root, foliar and postharvest diseases of plants -- 8. Bacillus spp. and their Biotechnological Roles in Green Industry -- 9. Application of Bacillus spp. for sustainable cultivation of potato (Solanum tuberosum L.) and the benefits -- 10. Phytostimulation and biocontrol by the plant-associated Bacillus amyloliquefaciens FZB42 - an update -- 11. Potential and Prospects of Aerobic Endospore Forming Bacteria (AEFB) in Crop Production -- 12. Thermostable α-Amylase from Geobacillus – A Review -- 13. New insights in plant associated Paenibacillus species: biocontrol and plant-growth promoting activity -- 14. Lactobacillus: A Potential Probiotic -- 15. Expanding the horizons for the use of Paenibacillus species as PGPR for sustainable agriculture -- 16. Bacillus spp.: A prolific siderophore producer -- 17. Can Bacillus species enhance nutrients availability in agricultural soils?.
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  • 10
    In: Springer eBooks
    Description / Table of Contents: This book provides a comprehensive resource for researchers and students involved with studying the roles of Bacilli in sustainable crop production technologies. Chapters included in the book not only elaborate on beneficial traits of Bacilli, but also highlight utilization of these microbes for producing industrially important antibiotics, enzymes, probiotics and other useful biochemicals. Feeding ever increasing world population from shrinking arable acreage led to a synthetic input (fertilizer, growth regulator, pesticide etc.) based crop production system, which has been creating both environmental and health hazards and may also make the whole production system unsustainable. Researchers, food producers and consumers alike, now realize that this world needs effective, environmentally smart agricultural technologies that are safe for people use less synthetic inputs and protect natural resources. To overcome the challenge of increasing food production with a significant reduction of agrochemicals use, a great deal of interest and research have been devoted to beneficial microorganisms/biostimulants in recent days with noteworthy positive results. Bacillus based biopesticide together with other bio-rational approaches may play a critical role in helping all the key drivers of sustainable, environmentally responsible food production with enhanced food quality. Although multiple strains of Bacillus spp. showed promise to contribute to the sustainable agriculture by making nutrients available to plants, providing additional defense to adverse abiotic and biotic stresses, research on Bacillus based product formulation, rate and crop selection, optimization of application timing are urgently needed. As crop plants are more vulnerable to abiotic and biotic stresses at the seedling stage, optimization of application timing should aid in alleviating those stresses for the successful completion of life cycle of a plant.
    Type of Medium: Online Resource
    Pages: VI, 335 p. 66 illus., 26 illus. in color. , online resource.
    Edition: 1st ed. 2019.
    ISBN: 9783030151751
    Series Statement: Bacilli in Climate Resilient Agriculture and Bioprospecting,
    Language: English
    Note: 1. Management of fungal diseases on cucumber (Cucumis sativus L.) and tomato (Solanum lycopersicum L.) crops in greenhouses using Bacillus subtilis -- 2. Bacillus species: A potential plant growth regulator -- 3. Bacilli in the Biocontrol of Mycotoxins -- 4. Bacillus subtilis and its effect on the post-harvest of fruit and flowers -- 5. Plant growth-promotion by ACC deaminase-producing Bacilli under salt stress conditions -- 6. Bacillus subtilis-mediated Abiotic Stress Tolerance in Plant -- 7. Exploring the Utility of Aneurinibacillus as a Bioinoculant for Sustainable Crop Production and Environmental Applications -- 8. Phylogeny and Taxonomy of agriculturally important Bacillus species -- 9. Endophytic Bacillus species induced systemic resistance to plant diseases -- 10. Genomics and Post-genomics Approaches for Elucidating Molecular Mechanisms of Plant Growth Promoting Bacilli -- 11. Tapping the Potential of Metabolomics in New Natural Products Discovery from Bacillus Species -- 12. Genomic insights and comparative genomics of Bacillus species having diverse mechanisms of biocontrol against fungal phytopathogens -- 13. Bacillus species as biocontrol agents for fungal plant pathogens -- 14. Application Method and Efficacy of Bacillus spp in Mitigating Abiotic and Biotic Stresses and Enhancing Plant Performance -- 15. Bacillus thuringiensis-based Gene Pyramiding a way Forward for a Combined Horizontal and Vertical Resistance in Plant -- 16. Probiotic Bacilli in Sustainable Aquaculture.
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