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Mutant Presenilin 2 Transgenic Mouse: Effect on an Age-Dependent Increase of Amyloid β-Protein 42 in the Brain (1998)

Oyama, Fumitaka ; Sawamura, Naoya ; Kobayashi, Kimio ; [et al.]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 71 (1998), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: The N141I missense mutation in presenilin (PS) 2 is tightly linked with a form of autosomal dominant familial Alzheimer's disease (AD) in the Volga German families. We have generated transgenic mouse lines overexpressing human wild-type or mutant PS2 under transcriptional control of the chicken β-actin promoter. In the brains of transgenic mice, the levels of human PS2 mRNA were found to be five- to 15-fold higher than that of endogenous mouse PS2 mRNA. The amyloid β-protein (Aβ) 42 levels in the brains of mutant PS2 transgenic mice were higher than those in wild-type PS2 transgenic mice at the age of 2, 5, or 8 months. In addition, the Aβ42 levels appeared to increase steadily in the mutant PS2 transgenic mouse brains from 2 to 8 months of age, whereas there was only a small increase in wild-type transgenic mice between the ages of 5 and 8 months. There was no definite difference in the levels of N-terminal and C-terminal fragments between wild-type and mutant PS2 transgenic mice at the age of 2, 5, or 8 months. These data show a definite effect of the PS2 mutation on an age-dependent increase of Aβ42 content in the brain.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1046/j.1471-4159.1998.71010313.x

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Isolation and Characterization of Helicobacter Species from the Stomach of the House Musk Shrew (Suncus murinus) with Chronic Gastritis (1998)

Goto, Kazuo ; Ohashi, Hiroaki ; Ebukuro, Susumu ; [et al.]

Springer

Current microbiology 37 (1998), S. 44-51

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ISSN: 1432-0991

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract. A Gram-negative, motile bacterium with bipolar sheathed flagella (one at each end) was isolated from the stomach of house musk shrews (Suncus murinus) with chronic gastritis. The isolates grew at 37°C under microaerophilic conditions, but not under aerobic conditions; rapidly hydrolyzed urea; were catalase, oxidase, alkaline phosphatase, and arginine aminopeptidase positive; reduced nitrate to nitrite; and were resistant to cephalothin and nalidixic acid, but sensitive to tetracycline, erythromycin, and chloramphenicol. This bacterium was found on gastric epithelial cells by electron microscopy. In addition, a coccoid form of the bacteria was found in vacuoles formed in the epithelial cells of some of the house musk shrews tested. These results, including 16S rRNA gene sequence analysis, strongly suggested that this bacterium should be classified as a novel Helicobacter species. It is proposed that this bacterium should be called “Helicobacter suncus.”

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/s002849900335

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A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord (2006)

Kaneko, Shinjiro ; Iwanami, Akio ; Nakamura, Masaya ; [et al.]

[s.l.] : Nature Publishing Group

Nature medicine 12 (2006), S. 1380-1389

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ISSN: 1546-170X

Source: Nature Archives 1869 - 2009

Topics: Biology , Medicine

Notes: [Auszug] Axons in the adult mammalian central nervous system (CNS) exhibit little regeneration after injury. It has been suggested that several axonal growth inhibitors prevent CNS axonal regeneration. Recent research has demonstrated that semaphorin3A (Sema3A) is one of the major inhibitors of axonal ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nm1505

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Lymphocyte engraftment conveys immunity and alters parasite development in scid mice infected withEchinococcus multilocularis (1993)

Playford, Matthew C. ; Ooi, Hong-Kean ; Ito, Mamoru ; [et al.]

Springer

Parasitology research 79 (1993), S. 261-268

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ISSN: 1432-1955

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Abstract Severe combined immune-deficient (scid) mice, which lack functional B- and T-lymphocytes, were infected withEchinococcus multilocularis larval tissue before or after reconstitution with lymphoid cells from immunocompetent donor mice. Untreated scid mice were highly susceptible toE. multilocularis infection, while scid mice reconstituted with purified lymphocytes derived from either infected or uninfected normal donor mice were capable of almost totally suppressing the growth of the larval cyst mass. The somatic development of the larval parasite varied according to the infection status of the cell donor, with protoscolices forming in scid mice reconstituted with cells from uninfected normal mice but not in those receiving cells from infected normal mice. These results confirm earlier findings that lymphocytes are important in suppressing the growth ofE. multilocularis cysts in the intermediate host and also indicate that protoscolex development is influenced by lymphocytes or their products.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00932179

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Investigations on polyethers containing nitro-groups. I. The cationic copolymerization of glycidyl nitrate with other cyclic ethers (1970)

Abe, Satsuki ; Ito, Mamoru ; Namba, Keiho

New York : Wiley-Blackwell

Die Makromolekulare Chemie 134 (1970), S. 121-127

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ISSN: 0025-116X

Keywords: Chemistry ; Polymer and Materials Science

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Physics

Description / Table of Contents: Die kationische Copolymerisation von Glycidylnitrat (GN) mit einigen cyclischen Äthern wurde durchgeführt, um die Bedingungen zu ermitteln, unter denen Glycidylnitrat mit diesen Äthern copolymerisiert.Propylenoxid (PO), 3.3-Bis(chlormethyl)oxacyclobutan (BCMO), Tetrahydrofuran (THF) und Trioxan (TO) wurden als Comonomere angewendet. Bortrifluorid-Komplexe von LEWIS-Säuren waren die aktivsten Katalysatoren. Die Copolymerisationsparameter wurden abgeschätzt: r1 = 0.03, r2 = 1.85 für die Copolymerisation von GN(M1)/PO(M2); r1 = 0.07, r2 = 0.88 für die Copolymerisation von GN(M1)/THF(M2); r1 = 0.3, r2 = 0.35 für die Copolymerisation von GN(M1)/TO(M2).

Notes: Cationic copolymerizations of glycidyl nitrate (GN) with some cyclic ethers were carried out to determine conditions under which glycidyl nitrate could be copolymerized with other ethers. Propylene oxide (PO), 3.3-bis(chloromethyl) oxacyclobutane (BCMO), THF and trioxane (TO) were used as comonomers. In LEWIS acids, boron trifluoride complexes were the most active catalysts.The copolymerization parameters were estimated as follows: r1 = 0.03 and r2 = 1.85 for GN(M1)/PO(M2), r1 = 0.07 and r2 = 0.88 for GN(M1)/THF(M2) and r1 = 0.3 and r2 = 0.35 for GN(M1)/TO(M2) copolymerization.

Additional Material: 5 Ill.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1002/macp.1970.021340110

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