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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20091021-20091024; Berlin; DOCPO17-326 /20091015/
    Publication Date: 2009-10-16
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé On a effectué l'examen histologique de 15 échantillons biopsiques du tissu de régénération cartilagineux de la surface d'appui de l'articulation de la hanche. Ces échantillons ont été prélevés sur 15 malades qui avaient subi avec succès une ostéotomie de valgisation fémorale. Chez 6 des ces 15 patients, les 3 couches du tissu de régénération étaient fortement colorées par la safranine O. Cependant, chez 6 autres patients, cette coloration n'était observée que dans les couches intermédiaires et profondes, tandis que, chez 2 patients, seule la couche profonde était colorée. Une immuno-histochimie pratiquée avec la protéine S-100 sur 5 échantillons a permis le marquage de toutes les cellules. Ceci a montré que les cellules du tissu de régénération étaient des chondrocytes. Cependant il n'y avait pas de ligne d'ossification dans le tissu de régénération et l'agencement des cellules différait de celui d'un cartilage normal. On a noté également une discontinuité de l'os sous-chondral. Ces résultats indiquent qu'il est trés probable que le tissu de régénération soit d'origine médullaire.
    Notes: Summary In this study biopsy specimens of the surface repair tissue from the weightbearing area of the hip joint were collected from 15 patients who had undergone successful valgus osteotomy, and these were examined histologically. In 6 of the 15 patients the specimens stained strongly with safranin-O in all three layers of the matrix. However, the repair tissue from another 6 patients showed strong staining only in the intermediate and deep layers, while that from 2 patients stained only in the deep layer. Specimens from 5 patients were stained for S-100 protein and positive cells were detected in all cases, demonstrating that the cells in the repair tissue were chondrocytes. However, there was no tide mark in the repair tissue and the arrangement of the cells differed from that in normal cartilage. Discontinuity of the subchondral bone was also noted. These findings make it likely that the repair tissue was of bone marrow origin.
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  • 3
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    Electronic Resource
    Springer
    International orthopaedics 15 (1991), S. 161-165 
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Les effets des différentes techniques de préparation sur les propriétés biomécaniques et sur l'incorporation histologique de l'os ont été étudiés chez le rat pendant une période de 6 mois. Les résultats de l'étude biomécanique ont montré que la rigidité osseuse était augmentée après congélation à −80° C et lyophilisation. L'os décalcifié était très mou. Les analyses biomécaniques faites durant une période de 6 mois après la greffe ont montré une importante visco-élasticité pendant 4 à 12 semaines et une rigidité du greffon à partir de la 16ème semaine. Cette augmentation progressive de la rigidité était parallèle à l'incorporation progressive du greffon. La proportion d'incorporation du greffon a été proposée par les auteurs comme indicateur histologique de la propriété ostéo-inductive. Le meilleur rapport est donné par l'autogreffe fraîche, puis par les allogreffes préparées (congelées, lyophilisées et décalcifiées) et enfin par les allogreffes fraîches. Les valeurs de ces trois groupes présentent une différence significative sur le plan statistique.
    Notes: Summary The effects of various processing techniques on the biomechanical properties and the histological incorporation of bone grafts were investigated in a rat model over a 6 month period. The stiffness of bone increased after freezing to −80° C and freeze-drying. Decalcified bone was very soft. Visco-elasticity was pronounced at 4 to 12 weeks and the stiffness of the graft increased at 16 weeks. This progressive rise in stiffness was in line with the progressive incorporation of the graft. The bone incorporation ratio is proposed as a histological indicator of osteo-inductive properties. It was found to be best in fresh autografts, followed by processed allografts (frozen, freeze-dried and decalcified) and fresh allografts. The values of these 3 groups showed a statistically significant difference.
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  • 4
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Dix patients avec un cal vicieux en rotation du fémur ou du tibia ont fait l’objet d’une correction par une ostéotomie intramédullaire à foyer fermé. Il y avait 9 hommes et une femme. L’âge moyen est compris entre 18 et 56 ans. Huit patients présentaient un cal en rotation externe du fémur et les deux autres avaient un tibia déformé. Le cal vicieux en rotation variait de 30 à 60 degrés et était associéà un raccourcissement de 15 à 30 mm dans 6 cas. Toutes les ostéotomies de dérotation ont été réalisées par section intramédullaire et fixées par clou verrouillé. Le raccourcissement a été corrigé dans le même temps opératoire. Le plus récent contrôle des patients montre que la déformation résiduelle est moins que 5 degrés et le raccourcissement de moins de 15 mm. Tous les patients étaient satisfaits de la longueur et la mobilité du membre inférieur opéré. Il n’y eut aucune complication per- ou postopératoire sauf un retard de consolidation. Dans ce dernier cas, la consolidation fut obtenue à 2 ans sans intervention supplémentaire. L’ostéotomie intramédullaire est la fa*on la plus sûre d’obtenir la correction d’un cal vicieux rotatoire d’un os long, avec un taux de complication minimal.
    Notes: Summary. Ten patients with rotational deformities after fractures of the femur or tibia were treated by closed intramedullary osteotomy. Eight had an external rotation deformity of the femur and 2 had deformities of the tibia. The rotational deformity varied from 30° to 60° and 6 patients had shortening of 15 mm to 30 mm. The osteotomies were carried out with an intramedullary saw and were fixed by an interlocking nailing. Shortening was corrected at the same time. At follow up the average rotational deformity was less than 5° and shortening less than 15 mm. All the patients felt that they had a normal range of movement and equal length. There were no complications, except for one case of delayed union in which consolidation occurred at 24 months without any further procedures.
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  • 5
    ISSN: 1420-908X
    Keywords: Collagen ; Arthritis ; Cyclosporin and hyaluronan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum hyaluronan (HA) levels were measured in a rat model of collagen arthritis using a sandwich enzyme-linked immunosorbent assay. Values became elevated as the arthritis developed, correlating with its severity. Daily subcutaneous treatment with cyclosporin at the dose of 25 mg/kg per day for fourteen days completely prevented anti-type II collagen antibody production and the serum HA increase as well as development of collagen arthritis. HA in the blood may thus provide a good quantitative marker for joint disease in rat collagen arthritis with potential as a tool for evaluation of drug efficacy in this experimental model.
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  • 6
    ISSN: 1420-908X
    Keywords: Immunity ; Type II collagen ; Proteoglycan ; Osteoarthritis ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We measured immunity to type II collagen and proteoglycans in osteoarthritic C57BL mice to determine whether it is related to osteoarthritis pathogenesis. Histological examination revealed articular cartilage lesions in all mice and synovitis in only a few mice. Immunological responses to type II collagen were found in collagen arthritic mice, but not in C57BL mice. Furthermore, immunological responses to proteoglycans were observed in proteoglycan-immunized mice, but not in C57BL mice. Therefore, articular cartilage degeneration may not result in autoimmunity to type II collagen and proteoglycans in osteoarthritis of C57BL mice, and immune responses to these components may not be a primary etiology of osteoarthritis in this model.
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  • 7
    ISSN: 1573-9686
    Keywords: Osteoporosis ; Trabecular structure ; Bone metabolism ; Femoral neck fracture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Progression of osteoporosis is caused by a decline in bone formation activity relative to the resorption activity. In this paper, the authors carried out a theoretical analysis of the progression of osteoporosis to estimate the osteoporotic change in the upper end of the femur. According to this analysis, the progression rate of osteoporosis in cancellous bone depends on the product of remodeling activity,R act, and the trabecular structure parameter,K tr. To confirm that the theoretical results were reasonably comparable to actual osteoporotic change, these two factors were measured in rabbits. From the results, it was concluded that the highest progression rate was shown in bar/barlike trabecular structure (type 3); the next highest rate, was shown in plate/bar-like structure (type 2); and the plate/plate-like structure (type 1) was the most insensible. Furthermore, the bone volume fractions of cancellous bone were measured at the upper end of human femurs with and without osteoporosis. Then the measured value was compared with the theoretical value for each type of trabecular structure. Results showed that the decrease in bone volume fraction predicted by Eq. 7 was well in accord with the actual decrease.
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  • 8
    ISSN: 1573-6814
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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