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  • 1
    ISSN: 1600-0501
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Aim: The purpose of this study was to evaluate the effect of excessive occlusal load following placement of titanium implants in the presence of healthy peri-implant mucosal tissues.Materials and methods: Mandibular bilateral recipient sites in six Labrador dogs were established by extracting premolars and molars. After 3 months, two TPS (titanium plasma sprayed) implants and two SLA (sandblasted, large grit, acid etched) implants were placed on each side of the mandible in each dog. Three implants were lost in the initial healing phase, leaving 45 implants for evaluation. Following 6 months of healing, gold crowns were placed on implants on the test side of the mandible. The crowns were in supra-occlusal contact with the opposing teeth in order to create excessive occlusal load. Implants on the control side were not loaded. Plaque control was performed throughout the experimental period. Clinical measurements and standardised radiographs were obtained at baseline and 1, 3 and 8 months after loading. At 8 months, the dogs were killed and histologic analyses were performed.Results: At 8 months, all implants were osseointegrated. The mean probing depth was 2.5±0.3 and 2.6±0.3 mm at unloaded and loaded implants, respectively. Radiographically, the mean distance from the implant shoulder to the marginal bone level was 3.6±0.4 mm in the control group and 3.7±0.2 mm in the test group. Control and test groups were compared using paired non-parametric analyses. There were no statistically significant changes for any of the parameters from baseline to 8 months in the loaded and unloaded implants. Histologic evaluation showed a mean mineralised bone-to-implant contact of 73% in the control implants and 74% in the test implants, with no statistically significant difference between test and control implants.Conclusion: In the presence of peri-implant mucosal health, a period of 8 months of excessive occlusal load on titanium implants did not result in loss of osseointegration or marginal bone loss when compared with non-loaded implants.
    Type of Medium: Electronic Resource
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  • 2
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 1340-1348 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This is the first of two articles dealing with fluid flow in compressible porous media. In this article a model describing fluid flow and pressure-induced variations in porosity under stationary conditions is developed. In a forthcoming article the dynamic behavior during filtration and wet pressing of compressible porous media are presented.Fluid flow through rigid porous media is generally described by Darcy's law. The corresponding expression for compressible materials is derived in this article. This expression, the steady-state flow (SSF) equation, allows the steady-state flow to be easily calculated, either numerically, or by using the approximative analytical solutions that are also presented here. In the SSF equation optional empirical and/or theoretical permeability and compressibility relationships may be combined. Further, a new compressibility model which also applies for viscoelastic materials is presented. The influence of the compressibility of the material and the influence of precompression is illustrated.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 38 (1992), S. 1349-1356 
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: This article deals with the dynamic behavior during filtration and wet pressing of compressible porous media. An equation is developed which permits the derivation of the time dependency of porosity and flow at varying locations in a medium subjected to hydraulic pressure and/or mechanical load. Furthermore, a numerical solution that allows the equation to be solved rapidly and with high accuracy on a common PC is presented. The computer program developed in conjunction with this work has been used to illustrate the dynamics of fluid flow in some industrially important applications, such as wet pressing of paper pulp and flow in chromatography columns. The program has also been used to calculate the flow and concentration variations during mechanical impulse loading (that is, a press pulse).
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 5
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  128. Kongress der Deutschen Gesellschaft für Chirurgie; 20110503-20110506; München; DOC11dgch773 /20110520/
    Publication Date: 2011-05-20
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  128. Kongress der Deutschen Gesellschaft für Chirurgie; 20110503-20110506; München; DOC11dgch630 /20110520/
    Publication Date: 2011-05-20
    Keywords: ddc: 610
    Language: English
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  • 7
    ISSN: 0920-5632
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-0932
    Keywords: Disque intervertébral ; Réintervention ; IRM ; Tomodensitométrie ; Saccoradiculographie ; Intervertebral disk ; Reoperation ; Magnetic resonance imaging ; Computed tomography ; Myelography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The differentiation between scar tissue and disk herniation is essential in postdiskectomy problems of the lumbar spine, since reoperation on scar tissue alone is often unfavourable. Epidural scar is a vascularized tissue, and enhancement can be seen after intravenous contrast injection, allowing differentiation from avascular disk material. Ten patients who had previously undergone surgery for lumbar disk herniation and with recurrent symptoms severe enought to warrant repeat surgery were examined by myelography, magnetic resonance imaging (MRI), and computed tomography (CT) before reoperation. MRI was performed with T1- and T2-weighted sequences in sagittal and axial projections before and after intravenous contrast injection. CT scans were obtained before and during intravenous contrast infusion. Reoperation revealed scar tissue, alone or together with disk, in 9 of 10 patients. Enhancement of scar but not of disk material was observed on MRI in 8 cases, but in none on CT. No enhancement of disk was seen with either modality. The correct diagnosis was given by MRI in 9 of 10 patients and by CT in 3 of 10. CT was superior to MRI in only 1 patient, who had a bony stenosis. Myelography could not separate disk from scar in any case. In conclusion, contrast-enhanced MRI was superior to MRI without contrast, CT before and after contrast, as well as myelography in discriminating disk from scar tissue.
    Notes: Résumé Il est essentiel de faire la part entre la fibrose cicatricielle et une hernie discale au cours des récidives symptomatiques survenant après une discectomie lombaire, car la réintervention pour une fibrose cicatricielle isolée aboutit le plus souvent à un résultat défavorable. La fibrose épidurale est un tissu vascularisé qui peut être rehaussé par l'injection intra-veineuse d'un produit de contrast permettant de la distinguer du matériel discal avasculaire. Dix patients ayent été préalablement opérés pour hernie discale et présentant une récidive symptomatique assez sévère pour justifier un éventuel geste chirurgical, ont été explorés avant la réintervention par saccoradiculographie, IRM et tomodensitométrie. L'IRM a été rélisée avec des séquences pondérées en T1 (T1-w) et T2 (T2-w), dans les plans sagittal et transversal, avant et après injection d'un produit de contraste. Les coupes tomodensitométriques ont été réalisées avant et pendant la perfusion intraveineuse du produit de contraste. Chez 9 patients sur 10, la réintervention a mis en évidence le tissue cicatriciel, seul ou accompagné de substance discale. Dans 8 cas l'IRM a permis de mettre en évidence un rehaussement au niveau de la fibrose cicatricielle, sans aucune prise de contraste au niveau du disque; en aucun cas celà n'a été observé au scanner. Quelle que soit la modalité d'exploration, aucun rehaussement n'a été observé au niveau de la substance discale. Le diagnostic correct a été donné par l'IRM dans 9 cas sur 10 et par le scanner dans 3 cas seulement sur 10. La tomodensitométrie ne s'est montrée supérieure à l'IRM que chez un seul patient qui présentait une sténose canalaire osseuse. En aucun cas la saccoradiculographie n'a pu distinguer le disque du tissu cicatriciel. En conclusion, l'IRM avec injection de contraste est effectivement supérieure à l'IRM sans contraste, à la tomodensitométrie avec ou sans injection, ainsi qu'à la saccoradiculographie, pour distinguer la substance discale de la fibrose cicatricielle post-opératoire.
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  • 9
    ISSN: 1432-0983
    Keywords: Key words Laccase ; Trametes versicolor ; Heterologous expression ; Pichia pastoris
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A cDNA coding for laccase was isolated from the ligninolytic fungus Trametes versicolor by RNA-PCR. The cDNA corresponds to the gene lcc1, which encodes a laccase isoenzyme of 498 amino-acid residues preceded by a 22-residue signal peptide. The lcc1 cDNA was cloned into the vector pHIL-D2 for expression in Pichia pastoris under the control of the AOX1 promoter. Transformants were found to secrete active recombinant enzyme after induction with methanol. The use of growth medium buffered to pH 6.0 and control of pH during cultivation were found to be important, or even necessary, for obtaining activity in liquid cultures. The effect of exchanging the native secretion signal for the Saccharomyces cerevisiae α-factor pre-pro secretion signal was studied by cloning the portion encoding the mature enzyme into the vector pPIC9. The activity obtained for the construct encoding the native laccase signal sequence was found to be seven-fold higher than for the construct encoding the α-factor secretion signal. Utilisation of the P. pastoris pep4 mutant strain SMD1168 was found to provide a two-fold higher level of activity compared with P. pastoris GS115.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1041
    Keywords: dixyrazine ; gas chromatographic assay ; mass spectrometric assay ; plasma concentration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A gas chromatographic — mass spectrometric method for the determination of dixyrazine in plasma has been developed. The method was found to offer high specificity, sensitivity, accuracy and precision and should be adequate for analysis of dixyrazine kinetics in man. There appeared to be great inter-individual variation in the disposition of the drug.
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