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  • 1
    Publication Date: 2012-12-12
    Description: The earliest history of the Moon is poorly preserved in the surface geologic record due to the high flux of impactors, but aspects of that history may be preserved in subsurface structures. Application of gravity gradiometry to observations by the Gravity Recovery and Interior Laboratory (GRAIL) mission results in the identification of a population of linear gravity anomalies with lengths of hundreds of kilometers. Inversion of the gravity anomalies indicates elongated positive-density anomalies that are interpreted to be ancient vertical tabular intrusions or dikes formed by magmatism in combination with extension of the lithosphere. Crosscutting relationships support a pre-Nectarian to Nectarian age, preceding the end of the heavy bombardment of the Moon. The distribution, orientation, and dimensions of the intrusions indicate a globally isotropic extensional stress state arising from an increase in the Moon's radius by 0.6 to 4.9 kilometers early in lunar history, consistent with predictions of thermal models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Andrews-Hanna, Jeffrey C -- Asmar, Sami W -- Head, James W 3rd -- Kiefer, Walter S -- Konopliv, Alexander S -- Lemoine, Frank G -- Matsuyama, Isamu -- Mazarico, Erwan -- McGovern, Patrick J -- Melosh, H Jay -- Neumann, Gregory A -- Nimmo, Francis -- Phillips, Roger J -- Smith, David E -- Solomon, Sean C -- Taylor, G Jeffrey -- Wieczorek, Mark A -- Williams, James G -- Zuber, Maria T -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):675-8. doi: 10.1126/science.1231753. Epub 2012 Dec 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Geophysics and Center for Space Resources, Colorado School of Mines, Golden, CO 80401, USA. jcahanna@mines.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223393" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 2012-12-12
    Description: High-resolution gravity data obtained from the dual Gravity Recovery and Interior Laboratory (GRAIL) spacecraft show that the bulk density of the Moon's highlands crust is 2550 kilograms per cubic meter, substantially lower than generally assumed. When combined with remote sensing and sample data, this density implies an average crustal porosity of 12% to depths of at least a few kilometers. Lateral variations in crustal porosity correlate with the largest impact basins, whereas lateral variations in crustal density correlate with crustal composition. The low-bulk crustal density allows construction of a global crustal thickness model that satisfies the Apollo seismic constraints, and with an average crustal thickness between 34 and 43 kilometers, the bulk refractory element composition of the Moon is not required to be enriched with respect to that of Earth.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wieczorek, Mark A -- Neumann, Gregory A -- Nimmo, Francis -- Kiefer, Walter S -- Taylor, G Jeffrey -- Melosh, H Jay -- Phillips, Roger J -- Solomon, Sean C -- Andrews-Hanna, Jeffrey C -- Asmar, Sami W -- Konopliv, Alexander S -- Lemoine, Frank G -- Smith, David E -- Watkins, Michael M -- Williams, James G -- Zuber, Maria T -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):671-5. doi: 10.1126/science.1231530. Epub 2012 Dec 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Physique du Globe de Paris, Sorbonne Paris Cite, Universite Paris Diderot, Case 7071, Lamarck A, 5, rue Thomas Mann, 75205 Paris Cedex 13, France. wieczor@ipgp.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223394" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2012-12-12
    Description: Spacecraft-to-spacecraft tracking observations from the Gravity Recovery and Interior Laboratory (GRAIL) have been used to construct a gravitational field of the Moon to spherical harmonic degree and order 420. The GRAIL field reveals features not previously resolved, including tectonic structures, volcanic landforms, basin rings, crater central peaks, and numerous simple craters. From degrees 80 through 300, over 98% of the gravitational signature is associated with topography, a result that reflects the preservation of crater relief in highly fractured crust. The remaining 2% represents fine details of subsurface structure not previously resolved. GRAIL elucidates the role of impact bombardment in homogenizing the distribution of shallow density anomalies on terrestrial planetary bodies.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zuber, Maria T -- Smith, David E -- Watkins, Michael M -- Asmar, Sami W -- Konopliv, Alexander S -- Lemoine, Frank G -- Melosh, H Jay -- Neumann, Gregory A -- Phillips, Roger J -- Solomon, Sean C -- Wieczorek, Mark A -- Williams, James G -- Goossens, Sander J -- Kruizinga, Gerhard -- Mazarico, Erwan -- Park, Ryan S -- Yuan, Dah-Ning -- New York, N.Y. -- Science. 2013 Feb 8;339(6120):668-71. doi: 10.1126/science.1231507. Epub 2012 Dec 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139-4307, USA. zuber@mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23223395" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    ISSN: 1432-2242
    Keywords: DNA typing ; Genetic similarity ; Genetic structure ; Genetic resource conservation ; Vegetable and forage cole crops
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Effective conservation and the use of plant genetic resources are essential for future agricultural progress. Critical to this conservation effort is the development of genetic markers which not only distinguish individuals and accessions but also reflect the inherent variation and genetic relationships among collection holdings. We have examined the applicability of the random amplified polymorphic DNA (RAPD) assay for quick, cost-effective, and reliable use in addressing these needs in relation to collection organization and management. Twenty-five decamer oligonucleotide primers were screened individually with a test array composed of individuals representing a range of genetic relationships in Brassica oleracea L. (vegetable and forage cole crops). Over 140 reproducible, polymorphic fragments were generated for study. Each individual of the test array exhibited a unique molecular genotype and composites specific for accessions and botanical varieties could be established. An analysis of similarity based on amplified DNA fragments reflected the known genetic relationships among the selected entries. These results demonstrated that RAPD markers can be of great value in gene bank management for purposes of identification, measurement of variation, and establishment of genetic similarity at the intraspecific level.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1420-9071
    Keywords: Cyclic AMP ; receptors ; adenylyl cyclase ; phosphodiesterase ; protein kinase ; cAMP analogs
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract cAMP plays an essential role duringDictyostelium development both outside and inside the cell. Membrane-bound receptors and adenylyl cyclase are responsible for sensing and producing extracellular cAMP, whereas a phosphodiesterase is responsible for maintaining a low basal level. The molecular events underlying this type of hormone like signalling, which are now beginning to be deciphered, will be presented, in the light of cAMP analogue studies. The importance of intracellular cAMP for cell differentiation has been demonstrated by the central role of the cAMP dependent protein kinase. Mutants as well as strains obtained by reverse genetics will be reviewed which lead to our current understanding of the role of intracellular cAMP in the differentiation of both stalk and spore cells.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Balsalazide is a 5-aminosalicylic acid (mesalazine) pro-drug which has an inert carrier molecule instead of the sulfapyridine moiety of sulfasalazine. It is designed to deliver 5-aminosalicylic acid to the colonic mucosa without the sulfapyridine-associated side-effects encountered with sulfasalazine.Several studies have confirmed the efficacy and patient tolerance of balsalazide. When compared to mesalazine at equivalent doses, it induced symptomatic and complete remission of acute ulcerative colitis in a greater proportion of patients. In particular, patients with resistant left-sided disease were shown to have a higher probability of achieving remission. Balsalazide was beneficial in patients with troublesome nocturnal symptoms. It has a similar efficacy in maintaining remission when compared to sulfasalazine and mesalazine. The advantage of balsalazide over other 5-aminosalicylic acid compounds is its superior patient tolerability with minimal side-effects.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 340 (1989), S. 144-146 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The pDd56-Tag-cat and pDd63-Tag-cat constructs direct temporally correct, cell-type-specific and DIF-inducible gene expression after transformation into Dictyostelium (Fig. 1 a, b)3'9. They contain the simian virus 40 (SV40) nuclear localiz-ation signal10, and staining of cells with monoclonal ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 675-678 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The clone pTR48 contains a 2-kilobase (kb) cDNA insert derived from the human transferrin mRNA8. Using this clone as a probe, a set of five overlapping cDNA clones was isolated containing, in total, 5 kb of sequence derived from the human transferrin receptor mRNA (Fig. 1). The mRNA is slightly ...
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract The use of paint as a coating for toys intended for sale on the European market is controlled by a European Standard (EN 71-3: 1994-European Standard for the Safety of Toys, Part 3—Migration of Elements). This work is the result of a preliminary study organised by the European Commission to produce a new paint reference material which can be used to validate the test methods given in the European Standard. The migration of elements from painted panels and comminuted paint produced by the Laboratory of the Government Chemist, (U.K.) was studied. Several methods were used in this certification exercise and this work reports the recults of neutron activation analysis and inductively coupled plasma mass spectrometry to determine the migration of As, Ba, Cd, Cr, Hg, Pb, Se and Sb into a simulated stomach environment. Replicate extracts obtained from paint samples gave a precision of within 10% for most elements by both analytical techniques for the paint panels and for the comminuted paint sample. This preliminary study has shown that the standard method can provide reproducible results for each of the paint materials studied and indicates that the study should be continued to produce a fully certified paint reference material.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 35 (1994), S. 4145-4156 
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A space–time, locally identical to the usual de Sitter space–time but globally different because of a kink in its light cone field, is described in various coordinate systems. Two separate coordinate patches are needed. Each original patch is geodesically incomplete and so is extended by the Kruskal method. The space–time, which is not globally hyperbolic, is shown to be foliated by a family of hypersurfaces each of which is homeomorphic to a three-sphere but none of which is everywhere spacelike.
    Type of Medium: Electronic Resource
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