Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Keywords: CANCER ; COHORT ; RISK ; ASSOCIATION ; SUSCEPTIBILITY ; HEALTH ; DESIGN ; WOMEN ; MEN ; cancer risk ; NETHERLANDS ; UNITED-STATES ; TOBACCO ; ALCOHOL ; ALCOHOL-CONSUMPTION ; CONSUMPTION ; pancreatic cancer ; NESTED CASE-CONTROL ; LIFE-STYLE FACTORS ; ONCOLOGY ; case-control study ; REGRESSION ; ASSOCIATIONS ; PANCREATIC-CANCER ; pooled analysis ; CANCER-RISK ; BASE-LINE CHARACTERISTICS ; nested case-control study ; GENOME-WIDE ASSOCIATION ; WOMENS HEALTH ; COFFEE CONSUMPTION ; Type ; nested case control study
    Abstract: The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. 〉 0 to 〈 5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out
    Type of Publication: Journal article published
    PubMed ID: 20373013
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Annals of biomedical engineering 14 (1986), S. 241-256 
    ISSN: 1573-9686
    Keywords: Otolith model ; Numeric solution ; Frequency response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract The otolith organs are the linear motion sensors of the mammalian system. As part of the vestibular system, these small organs are located in the inner ear. Mathematically modeled, they consist of an overdamped second-order system with elastic, viscous damping and mass elements. The governing equations of motion which describe the relative velocity of the mass with respect to the skull consist of a set of three coupled partial integral-differential equations. When these equations are nondimensionalized, they yield two nondimensional parameters which characterize the dynamic response of the system. These nondimensional equations are solved numerically for the relative displacement of the otolith mass for various values of the two nondimensional parameters. The solutions generated are for a step change in skull velocity. These solutions indicate that the end organ upper breakpoint frequency is at least one order of magnitude higher than previously measured experimental values determined by first-order neuron recordings.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1573-2576
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In order to resolve discrepancies in the literature concerning the subcellular localization of NADPH oxidase, we disrupted human neutrophils by nitrogen cavitation and fractionated the subcellular organelles on a discontinuous sucrose density gradient. The lightest fraction was 20- to 40-fold enriched for piasma membranes as determined by the marker enzymes alkaline phosphatase and phosphodiesterase I as well as by the ratio of lipid phosphorus to protein. There was a significant decrease in the specific activities of the granule markers myeloperoxidase, lysozyme, andΒ-glucuronidase. An intermediate fraction was enriched in membrane markers but not to the extent the lightest fraction was enriched. This fraction contained more granular contamination, as shown by the marker enzymes. In contrast, the densest bands of the gradient were enriched for granule markers with little contamination by plasma membrane. Superoxide generation and NADP formation were primarily associated with the two membrane-enriched fractions from polymorphonuclear leukocytes stimulated with phorbol myristate acetate. The NADP formation associated with a dense granule fraction observed previously in our laboratory was probably due to a cyanide-stimulated oxidation of NADPH by myeloperoxidase.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We used magnetic resonance spectroscopy to examine endophthalmitis in rabbits inoculated with a virulent strain ofStreptococcus pneumoniae. On different days after infection, the animals were sacrificed and the vitreous isolated and examined with water-suppressed proton magnetic resonance spectroscopy. A broad resonance corresponding to the methyl envelope of lipoprotein lipids appeared 2 days after infection and persisted until the eyes developed phthisis (around 10 days postinfection). This resonance was absent in the control eye and the bacterial culture; it could be used as the marker of breakdown of blood-vitreous barrier and onset of endophthalmitis-induced changes.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We prospectively studied 29 consecutive eyes with proliferative diabetic retinopathy that showed media clear enough to enable characterization of vitreoretinal relationships by biomicroscopy. Vitreoretinal relationships were also determined by contact B-scan ultrasound. With both techniques, these relationships were documented by photographs and drawings. Biomicroscopy showed complete posterior vitreous detachment (PVD) in 4 eyes (14%), partial PVD in 18 (62%), and no PVD in 7 (24%). Ultrasound examination revealed complete PVD in 4 eyes (14%), partial PVD in 19 (66%), and no PVD in 6 (21 %). The results we obtained using ultrasound agreed significantly with those obtained by biomicroscopy [Cohen's kappa = 0.93, 95% confidence interval = (0.80, 1.06)]. Ultrasound detected vitreous changes more easily than biomicroscopy when mild media opacities were present and when the equatorial areas of the globe were examined. Results suggest that ultrasound is adequate to determine vitreoretinal relationships in eyes with clear media and that it is a good alternative to biomicroscopy in eyes with significant media opacities.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We retrospectively studied the correlation between the initial electroretinogram (ERG) recordings and the final visual acuities (VA) of 47 patients with central retinal vein obstruction (CRVO) after follow-up of more than 1 year. The a- and b-wave amplitudes and the b/a ratio with white flash were significantly larger in patients with good vision (VA 〉 20/200) than in those with poor vision (VA 〈 20/200). The b/a ratio and b-wave amplitude with white flash showed sensitivity and specificity of more than 78% for visual prognosis. The latest VA was 〈- 20/200 in all 20 patients with a subnormal b-wave amplitude and in all 15 with b/a ratio 〈 1.05. These results suggest that the ERG recorded soon after (CRVO) onset correlates strongly with visual prognosis.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Descriptions of the chromosome complements of one species of the Richardiidae, ten of the Otitidae and nine of the Platystomatidae, are added in this report to the two for Otitidae provided by Metz (1916). The 2n = 10 complement of the single Richardiidae species had a total complement length (TCL) of 68.7μ. Complements of the 12 Otitidae species ranged from 2n = 6 to 12 and averaged 45.8μ in TCL whereas those of nine Platysiomatidae ranged from 2n = 6 to 12 and averaged 41.4μ in TCL. Morphological differences between complements having the same chromosome number are discussed. A karyotype having a short telocentric sex pair and five meta-to submetacentric autosomal pairs constitutes a common karyological feature and could be the basic (primitive) karyotype of species of Acalyptrate and Calyptrate Diptera. It is suggested that the basic 2n = 12 complements of Drosophila species (10 rods and 2 dots) may be far from typical for species of such Diptera.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 101 (1979), S. 3592-3595 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The extracellular acidification rate of the human bone marrow cell line, TF-1, increases rapidly in response to a bolus of recombinant granulocyte-macrophage colony stimulating factor (GM-CSF). Extracellular acidification rates were measured using a silicon microphysiometer. This instrument contains micro-flow chambers equipped with potentiometric sensors to monitor pH. The cells are immobilized in a fibrin clot sandwiched between two porous polycarbonate membranes. The membranes are part of a disposable plastic “cell capsule” that fits into the microphysiometer flow chamber. The GM-CSF activated acidification burst is dose dependent and can be neutralized by pretreating the cytokine with anti-GM-CSF antibody. The acidification burst can be resolved kinetically into at least two components. A rapid component of the burst is due to activation of the sodium/proton antiporter as evidenced by its elimination in sodium-free medium and in the presence of amiloride. A slower component of the GM-CSF response is a consequence of increased glycolytic metabolism as demonstrated by its dependence on D-glucose as a medium nutrient. Okadaic acid (a phospho-serine/threonine phosphatase inhibitor), phorbol 12-myristate 13-acetate (PMA, a protein kinase C (PKC) activator), and ionmycin (a calcium ionophore) all produce metabolic bursts in TF-1 cells similar to the GM-CSF response. Pretreatment of TF-1 cells with PMA for 18 h resulted in loss of the GM-CSF acidification response. Although this treatment is reported to destroy protein kinase activity, we demonstrate here that it also down-regulates expression of high-affinity GM-CSF receptors on the surface of TF-1 cells. In addition, GM-CSF driven TF-1 cell proliferation was decreased after the 18 h PMA treatment. Short-term treatment with PMA (1-2h) again resulted in loss of the GM-CSF acidification response, but without a decrease in expression of high-affinity GM-CSF receptors. Evidence for involvement of PKC in GM-CSF signal transduction was obtained using calphostin C, a specific inhibitor of PKC, which inhibited the GM-CSF metabolic burst at a subtoxic concentration. Genistein and herbimycin A, tyrosine kinase inhibitors, both inhibited the GM-CSF response of TF-1 cells, but only at levels high enough to also inhibit stimulation by PMA. These results indicate that GM-CSF activated extracellular acidification of TF-1 cells is caused by increases in sodium/proton antiporter activity and glycolysis, through protein kinase signalling pathways which can be both activated and down-regulated by PMA. © 1993 Wiley-Liss, Inc.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Chromosoma 24 (1968), S. 233-242 
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract This report describes the karyotypes of fourteen species of the tribe Chrysotoxini (Diptera, Syrphidae) with the single genus Chrysotoxum. The species are listed in the Table on p. 240. All have 2n=10 chromosomes, usually consisting of short apparently telocentric sex chromosomes plus two subtelocentric and two submetacentric pairs of autosomes.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...