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  • 1
    Washington, D.C : Brookings Institution
    Keywords: United States, Foreign relations, Philosophy. ; United States, Foreign relations, 2001- ; Bush, George W., (George Walker),, 1946-, Views on international relations. ; Balance of power. ; September 11 Terrorist Attacks, 2001, Influence. ; Unilateral acts (International law) ; War on Terrorism, 2001-, Diplomatic history.
    Notes: The Bush revolution -- George Bush and the Vulcans -- Bush's worldview -- Building a team -- The first eight months -- September 11 -- Onto the offensive -- The Bush strategy -- The inevitable showdown -- The Iraq war -- Who's next? -- The perils of power
    Pages: vii, 246 p.
    ISBN: 0-8157-9661-7
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  • 2
    Charlottesville, Va : University of Virginia Library
    Keywords: Russia, Social life and customs, Fiction. ; Chekhov, Anton Pavlovich,, 1860-1904, Translations into English.
    ISBN: 0-585-20420-9
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  • 3
    Cham : Springer International Publishing
    Keywords: Life sciences ; Nutrition ; Diabetes ; Hepatology ; Metabolic Diseases ; Biochemistry ; Life sciences ; Biochemistry, general ; Metabolic Diseases ; Hepatology ; Diabetes ; Nutrition ; Springer eBooks
    Description / Table of Contents: Transcriptional Regulation of De Novo Lipogenesis in Liver -- The Molecular Basis of Hepatic De Novo Lipogenesis in Insulin Resistance -- Regulation of Hepatic Metabolism by the Mechanistic Target of Rapamycin -- FoxO1: A Conductor of Insulin Signaling to Glucose and Lipid Metabolism -- Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease -- Role of the Endocannabinoid System in Hepatic Lipogenesis -- Role of Lipogenesis and Lipid Desaturases in Non-Alcoholic Fatty Liver Disease -- Lipid Droplet Proteins and Lipid Metabolism -- Influence of Gut Microbiota on Hepatic Lipogenesis and Disease Pathogenesis -- Hepatic Lipogenesis: Nutritional Control and Pathophysiological Relevance -- Metabolic Rhythm of Hepatic Lipogenesis: Regulation and Roles in Metabolism -- Monounsaturated Fatty Acid Mediated Liver-adipose Tissue Crosstalk and Metabolic Regulation -- Adipose Tissue DNL and Its Role in Metabolic Homeostasis -- The Lipogenic Effect of Insulin Revisited -- Index.℗
    Abstract: The liver is the largest solid vital organ in mammals that supports other organ in the body in some facet.℗ This book synthesizes all the primary and relevant metabolic information that one needs to review to understand the complex and diverse role of the liver in metabolism. With the current epidemic of metabolic diseases, it is of immediate importance to understand the contribution of the liver in health and its role in the development of impaired metabolic regulation. This book covers the many studies that have unmasked important roles that proteins expressed in the liver play in the development of or protection from metabolic diseases. One of the major metabolic functions of the liver is to carry out de novo lipogenesis, which is the metabolic pathway that allows the conversion of excess carbohydrates into fatty acids. The process of de novo lipogenesis is covered in depth within this volume. ℗ The book is an important contribution to the vast literature and ongoing research on liver function
    Pages: XI, 305 p. 35 illus., 5 illus. in color. : online resource.
    Edition: 1st ed. 2016.
    ISBN: 9783319250656
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  • 4
    Keywords: Medicine ; Neurosciences ; Neurobiology ; Biomedicine ; Neurosciences ; Neurobiology ; Mathematical Models of Cognitive Processes and Neural Networks ; Springer eBooks
    Description / Table of Contents: Introduction: Origins and History of the Annual CNS meetings -- A Pictorial History of the Early Days of Computational Neuroscience:℗ The CNS Meeting Posters -- History of Neural Simulation Software -- Learning from the past:℗ Approaches for Reproducibility in Computational Neuroscience -- The Emergence of Community Models in Computational Neuroscience: The 40-year History of the Cerebellar Purkinje Cell -- Calcium: the Answer to Life, the Universe, and Everything -- The more we look, the more biological variation we see: How has and should this influence modeling of small networks? -- 20 years of ́€œnois逝: Contributions of computational neuroscience to the exploration of the effect of background activity on central neurons -- Still looking for the memories: molecules and synaptic plasticity -- 20 years of the dynamics of memory: The long and winding road linking cellular mechanisms to behavior -- Spatiotemporal coding in the olfactory system -- 20 years of learning about vision: Questions answered, questions unanswered, and questions not yet asked -- Reinforcement learning models then and now: from single cells to modern neuroimaging -- Index
    Abstract: Twenty years ago, the field of Computational Neuroscience was relatively new and many computer models were starting to be constructed of different structures and brain regions. This book seeks to answer the questions, what have we learned over the last twenty years using computational techniques? and what are the most significant challenges that remain?℗ The authors were selected to provide wide coverage of the applications of computational techniques to a broad range of questions and model systems in neuroscience.℗ In addition, several chapters consider the historical development of the field of Computational Neuroscience itself, including its associated modeling technology. These contributions recount the historical record, but also consider what developments are necessary to continue to advance computational understanding of brain function.℗ The book also includes an historical account of the establishment of the annual international meeting in Computational Neuroscience (the ́€œCNŚ€ meeting) more than twenty years ago, and includes annotated reproductions of the first twelve years of posters from that meeting. These posters in and of themselves have become famous in the field, hanging in many laboratories around the world and also in the halls of the NIH in Bethesda.℗ Created at the time as allegories for the state of Computational Neuroscience, they now tell their own story of the origins and development of the field
    Pages: XIV, 283 p. 78 illus., 46 illus. in color. : online resource.
    ISBN: 9781461414247
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  • 5
    Keywords: Medicine ; Human Genetics ; Endocrinology ; Lipids ; Biomedicine ; Human Genetics ; Endocrinology ; Lipidology ; Springer eBooks
    Description / Table of Contents: SCD genes of fatty acid synthesis -- SCD genes in heart metabolism -- SCD genes in liver metabolism -- SCD genes in harderian and perpetual glands -- SCD genes In lipogenesis -- SCD genes lipoproteins -- SCD genes in WAT -- SCD genes in muscle -- SCD genes in the brain -- SCD genes in inflammation -- SCD genes in ER Stress -- SCD genes in skin -- SCD genes in insulin signaling -- SCD genes in thermogenesis -- SCD genes in diabetes -- SCD genes atherosclerosis -- SCD genes in Adipocyte differentiation -- SCD genes and epigenetics -- SCD genes in fatty liver disease -- SCD genes in Colitis -- SCD genes in leptin signaling
    Abstract: James Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date
    Pages: XI, 239 p. 42 illus., 24 illus. in color. : online resource.
    ISBN: 9781461479697
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  • 6
    Keywords: Medicine ; Neurosciences ; Biomedicine ; Neurosciences ; Springer eBooks
    Description / Table of Contents: Part ℗ I. PDEs and Signaling, Circuitry, and Implications of CNS Functions and Disorders -- 1. Phosphodiesterase Diversity and Signal Processing within cAMP Signaling Networks -- 2. Current Understanding of PDE10A in the Modulation of Basal Ganglia Circuitry -- 3. Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases -- 4. The PDE4 cAMP-specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-enhancing Action -- 5. Phosphodiesterase-4B as a Therapeutic Target for Cognitive Impairment and Obesity-related Metabolic Diseases -- Part II. PDEs in Cognition of Aging and Alzheimeŕ€™s Disease -- 6. From age-related Cognitive Decline to Alzheimeŕ€™s Disease: A Translational Overview of the Potential role for Phosphodiesterases -- 7. The Past, Present, and Future of Phosphodiesterase-4 Modulation for age-induced Memory Loss -- 8. A Role for Phosphodiesterase 11A (PDE11A) in the Formation of Social Memories and the Stabilization of Mood -- 9. Role of PDE9 in Cognition -- Part III. PDEs in Parkinsoń€™s and Huntingtoń€™s Diseases -- 10. Regulation of Striatal Neuron Activity by Cyclic Nucleotide Signaling and Phosphodiesterase Inhibition: Implications for the Treatment of Parkinsoń€™s Disease -- 11. Role of Phosphodiesterases in Huntington's Disease -- Part IV. PDEs and Psychiatric Disorders -- 12. The role of Phosphodiesterase-2 in Psychiatric and Neurodegenerative Disorders -- 13. Phosphodiesterase 1: A Unique Drug Target for Degenerative Diseases and Cognitive Dysfunction -- 14. PDE Inhibitors for the Treatment of Schizophrenia -- Part V. PDEs and Others -- 15. Targeting Phosphodiesterases in Pharmacotherapy for Substance Dependence -- 16. Genetic Understanding of Stroke Treatment: Potential role for Phosphodiesterase Inhibitors -- 17. A unique sub-pocket for Improvement of Selectivity of Phosphodiesterase Inhibitors in CNS
    Abstract: PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic neucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthiritis. ℗ This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. ℗ The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs
    Pages: XIX, 471 p. 44 illus., 36 illus. in color. : online resource.
    ISBN: 9783319588117
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  • 7
    Call number: QZ241:9/24
    Keywords: Peripheral Nervous System Neoplasms / pathology
    Notes: "Under the Auspices of Universities Associated for Research and Education in Pathology, Inc."
    Pages: 421 p. : numerous ill.
    ISBN: 188104145X
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    QZ241:9/24 available
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  • 8
    Call number: QZ365WI320:118
    Keywords: Gastrointestinal Neoplasms
    Pages: xiii, 761 p., unnumbered colour plates : ill.
    ISBN: 0721689639
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    QZ365WI320:118 available
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  • 9
    Totowa, N.J. : Humana Press
    Associated volumes
    Call number: QH506:60/103
    Keywords: Pichia / genetics ; Pichia pastoris ; Yeast fungi / Biotechnology ; Genetic Vectors
    Notes: Includes index.
    Pages: xi, 270 p.
    ISBN: 0896034216
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    QH506:60/103 available
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  • 10
    Call number: C060:37
    Keywords: Nonparametric statistics ; Longitudinal method ; Estimation theory
    Pages: xii, 397 p. : ill.
    ISBN: 0387955569
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    C060:37 departmental collection or stack – please contact the library
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