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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 1 (1991), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: A numerical model has been developed to investigate the contaminant removal and air freshness in a ventilated two-zone enclosure. The average contaminants and the distributions of air age in each zone under variable positions of door, supply and exhaust are compared. The correlation between the average contaminants and each of the main parameters, such as door location, supply and exhaust positions etc., are presented, and the average air ages in both zones are illustrated against door position. It is found that the average air age in the upstream zone is less affected by the door position than that in the downstream zone, and that the door position near the side-walls seems to give better air circulation. It is also concluded that the supply and door positions affect the concentration in the upstream zone significantly, while the exhaust location does not seem to influence the average concentration in either the upstream or the downstream zone.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 4 (1994), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: A numerical study has been carried out to predict the indoor air quality in a newly painted partitioned office and to assess the effect of ventilation rate and partition layout on the pre-ventilation time required to allow the contaminant concentration level to drop to an acceptable level. The air-flow pattern, the time history of the average contaminant concentration level in the occupied zone, and the pre-ventilation time were computed by a CFD code with a K-ε turbulence model.A displacement ventilation system, with different operating conditions, was used to remove contaminants in the office. The VB emission model, developed by Guo and Tichenor (1992), has been improved to include the influence of non-uniform concentration distribution on contaminant emission rate from the paints. The average contaminant (VOC) concentration levels in the occupied zone and in each chamber were recorded hourly until the average concentrations in the office were less then 0.0005 g/m3.It has been found that the non-uniform concentration distri- bution greatly influences the decay rate of VOC emissions. The time required for the average concentration in each chamber to reach the threshold level is different, since they are non-uniform. The time differences between the chambers having the highest and lowest concentrations were 3 to 8 hours. The results also show that the time required to reduce the concentration in the occupied zone to the threshold level is dependent on the partition layout. For the same ventilation rate, the required time is approximately 4-8 hours longer when using a side layout than when using a central layout.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 78 (1995), S. 6679-6682 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Ferromagnetic resonance (FMR) measurement was performed at the frequency of 9.8 GHz and at the room temperature on a series of Fe-SiO2 granular films fabricated by the Ar+-beam sputtering technique. Our results indicated that when the iron volume fraction (fv) of the films exceeds 0.28, the FMR spectra are superpositions of volume modes and surface modes. The analysis on the effective anisotropy field suggests that the intrinsic anisotropy (including the volume and interface one) becomes maximal when fv near the percolation threshold (fp). In particular, it was found for the films with fv=0.42 that the spin wave resonance modes satisfy the relation Hres∝n with a separation field of about 174 Gs between the successive modes. Our study reveals that Fe particles are coupled by a yet unknown interparticle interaction when fv is just below fp. © 1995 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Indoor air 2 (1992), S. 0 
    ISSN: 1600-0668
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Medicine
    Notes: The influence of location of airborne particle source, ventilation rate, air inlet size, supply air velocity, air outlet location, and heat source on the dkributiuns of airborne particle concentration and draught risk in an operating room is investigated. The investigation is carried out by using a flow program with the k-E mdel of turbulence. Based on a standard case, five cases, each with one changed parameter, are computed, and the detailed field distributions of air velocity, temperature, airborne particle concentration, and draught risk are presented.The parametric study concludes that, for a better air quality and thermal comfort, it is desirable to use a higher inflow rate, a larger inlet area, and a uniform velocity profile of supply air. Outlet location and heat source have little influence on the disrributions of the particle concentration in the room. It has also been found that the distributions of particle concentration in the recirculating zone are very sensitive to the location of the particle sources.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2013
    Keywords: Sea anemone toxins (Anemonia sulcata toxins III and IV,Parasicyonis actinostoloides toxin) ; Crayfish giant axon ; Na inactivation ; Potential-dependent toxin action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Effects of toxins III and IV (ATX III and IV) from the sea anemoneAnemonia sulcata on the Na current of crayfish giant axons were studied. Both toxins slowed the inactivation of Na channels, producing a maintained Na current during a depolarizing voltage pulse. Using the intensity of the toxin-induced maintained current as an index for the fraction of Na channels to which toxin is bound, the toxin association and dissociation kinetics were analyzed. The dissociation rate of ATX III was increased by two orders of magnitudes by depolarizing the membrane from −70 to −40mV. This increase of the dissociation rate caused a marked decrease in the binding rate of ATX III to Na channels in the same potential range. ATX IV exhibited association and dissociation kinetics that had a potential dependency quite similar to that of ATX III in spite of different ionic charge distribution in these two toxins. The results support the view that the potential-dependent kinetics of these toxins are not due to an electrostatic interaction between the ionic charges of toxins and the membrane potential but result from a modulation of the binding energy depending on the gate configuration of the Na channel.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1439-6327
    Keywords: Ultrasound ; Telemetry ; Exercise ; Blood flow velocity ; Heart rate ; Blood pressure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Blood flow velocity in the common carotid artery and the electrocardiogram were measured simultaneously by telemetry in seven male subjects during 20-min walking on a treadmill at an exercise intensity corresponding to a mean oxygen uptake of 26.0 (SD 2.9) ml · kg −1 · min −1. The mean cardiac cycle was shortened from 0.814 (SD 0.103) s to 0.452 (SD 0.054) s during this exercise. Of this shortening, 73% was due to shortening of the diastolic period and 27% to shortening of the systolic period. In the relatively small shortening of the mean systolic period [from 0.377 (SD 0.043) s to 0.268 (SD 0.029) s], the isovolumetric contraction time was shortened by 56%. During exercise, the heart rate (f c) increased by 79.4% [from 74.3 (SD 9.3) beats · min −1 to 133.3 (SD 14.8) beats · min −1], and the peak blood velocity (S1) in the common carotid artery increased by 56.1% [from 0.82 (SD 0.10) m · s−1 to 1.28 (SD 0.11) m · s−1]. After exercise, the S1 decreased rapidly to the resting level. The f c decreased more slowly, still being higher than the initial resting level 5 min after exercise. The diastolic velocity wave and the end-diastolic foot decreased during exercise. The blood flow rate in the carotid artery increased transiently by 13.5% at the beginning of exercise [from 5.62 (SD 0.63) ml · s−1 to 6.38 (SD 0.85) ml · s−1] and by 26.5% at the end of the exercise period [from 5.62 (SD 0.63) ml · s−1 to 7.11 (SD 1.34) ml · s−1]. The increase of blood flow in the carotid artery at the onset of exercise may have been mainly related to cerebral activation, and partly to an increase of blood flow to the skin of the head. The physiological significance for cerebral function of the increase of blood flow in the artery after the end of exercise is unknown.
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  • 7
    ISSN: 1439-6327
    Keywords: Dynamic exercise ; Cerebral blood flow ; Flow resistance ; Resistance index ; Pulsatility index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cerebral blood volume flow and flow velocity have been reported to increase during dynamic exercise, but whether the two increase in parallel and whether both increases occur as functions of exercise intensity remain unsettled. In this study, blood flow velocity in the common carotid artery was measured using the Doppler ultrasound method in eight healthy male students during graded treadmill exercise. The exercise consisted of stepwise progressive increases and decreases in exercise intensity. The peak intensity corresponded to approximately 85% of maximal oxygen consumption. During this exercise, the heart rate (f c), mean blood pressure (BP) in the brachial artery and mean blood flow velocity (νcc) in the common carotid artery increased as functions of exercise intensity. At the peak exercise intensity, (f c), BP and νcc increased by 134.5%, 20.5% and 51.8% over the control levels before exercise (P 〈 0.01), respectively. The resistance index (RI) and pulsatility index (PI) were determined from the velocity profile and were expected to reflect the distal cerebral blood flow resistance. The RI and PI increased during the graded exercise, but tended to decrease at the highest levels of exercise intensity. As νcc increased with increases in exercise intensity it would be expected that cerebral blood flow would also increase at these higher intensities. It is also suggested that blood flow velocity in the cerebral artery does not proportionately reflect the cerebral blood flow during dynamic exercise, since the cerebral blood flow resistance changes.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0730-2312
    Keywords: K+-depleted cells ; insulin ; LDL ; HeLa cells ; cell cycle ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Cell cycle progression of synchronized HeLa cells was studied by measuring labeling of the nuclei with [3H]thymidine. The progression was arrested in a chemically defined medium in which K+ was replaced by Rb+ (Rb-CDM) but was restored upon addition of insulin and/or low density lipoprotein (LDL). Cells started DNA synthesis 12 hr after addition of insulin and/or LDL, regardless of the time of arrest, suggesting their arrest early in the G1 phase. After incubation of cells in Rb-CDM containing insulin or LDL singly for 3, 6, or 9 hr, replacement of the medium by that without an addition resulted in marked delay in entry of cells into the S phase, but in its replacement by medium containing both agents, the delay was insignificant. Synthesis of bulk protein, estimated as increase in the cell volume, was not strongly inhibited. From these results we conclude that cell cycle progression of HeLa cells in K--depleted CDM is arrested early in the G1 phase and that the arrest is due to lack of some protein(s) required for entry into the S phase that is synthesized in the early G1 phase.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 9
    Publication Date: 2018-12-21
    Description: Chemical Research in Toxicology DOI: 10.1021/acs.chemrestox.8b00071
    Print ISSN: 0893-228X
    Electronic ISSN: 1520-5010
    Topics: Medicine
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  • 10
    Publication Date: 2018-11-30
    Description: Chemical Research in Toxicology DOI: 10.1021/acs.chemrestox.8b00220
    Print ISSN: 0893-228X
    Electronic ISSN: 1520-5010
    Topics: Medicine
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