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  • 1
    Keywords: Medicine ; Radiology, Medical ; Computer vision ; Biomedical Engineering ; Biomedicine ; Molecular Medicine ; Imaging / Radiology ; Image Processing and Computer Vision ; Optics, Optoelectronics, Plasmonics and Optical Devices ; Biomedical Engineering ; Springer eBooks
    Description / Table of Contents: Part I: Molecular Imaging Theory and System -- Introduction -- Molecular Optical Simulation Environment -- Diffuse Optical Tomography -- Fluorescence Molecular Tomography -- Bioluminescence Tomography -- Positron Emission Tomography -- Radioisotope Labeled Molecular Imaging in SPECT -- MRI Facility-Based Molecular Imaging -- Other Molecular Imaging Technology -- Optical Multi-Modality Molecular Imaging -- Medical Image Processing and Analysis -- Part II: Molecular Probes -- Opportunities and Challenges of Radiolabeled Molecular Probes -- Oligonucleotide Probes -- Quantum Dots for Biological Imaging -- RGD-Based Molecular Probes for Integrin αvß3 Imaging -- Part III: Applications of Molecular Imaging -- Basics of Molecular Biology -- Molecular Imaging Techniques in Clinical Practice of Tumors -- Using Molecular Imaging Techniques to Study Protein-Protein Interactions -- Application of Molecular Imaging in Transgenic Animals -- Molecular Imaging Methods in Diabetes-Related Studies
    Abstract: "Molecular Imaging: Fundamentals and Applications" is a comprehensive monograph which describes not only the theory of the underlying algorithms and key technologies but also introduces a prototype system and its applications, bringing together theory, technology and applications. By explaining the basic concepts and principles of molecular imaging, imaging techniques, as well as research and applications in detail, the book provides both detailed theoretical background information and technical methods for researchers working in medical imaging and the life sciences. Clinical doctors and graduate students will also benefit from this book. Jie Tian is a professor at the Institute of Automation, Chinese Academy of Sciences, China
    Pages: XV, 699 p. : online resource.
    ISBN: 9783642343032
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  • 2
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    Dordrecht : Springer
    Keywords: Life sciences ; Agriculture ; Plant physiology ; Environmental chemistry ; Environmental management ; Soil conservation ; Life sciences ; Agriculture ; Plant physiology ; Biogeosciences ; Environmental management ; Environmental chemistry ; Soil Science & Conservation ; Springer eBooks
    ISBN: 9789400729476
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  • 3
    Keywords: Medicine ; Neurosciences ; Psychotherapy ; Clinical Psychology ; Experiential research ; Biomedicine ; Neurosciences ; Psychology Research ; Clinical Psychology ; Psychotherapy ; Springer eBooks
    Description / Table of Contents: Received view of addiction, relapse and treatment -- Definition of substance and non-substance addictions -- Similarities and differences in molecule and neural circuit of substance and non-substance addictions -- Similarities and differences in genetics of substance and non-substance addictions -- Similarities and differences in neuroimaging of substance and non-substance addictions -- Similarities and differences in cognitive psychology of substance and non-substance addictions -- Similarities and differences in diagnostic criterion of substance and non-substance addictions -- Similarities and differences in diagnostic scales of substance and non-substance addictions -- Similarities and differences in biochemical diagnosis of substance and non-substance addictions -- Development of new diagnostic techniques of substance and non-substance addictions -- Drug therapy for substance and non-substance addictions -- Physical therapy for substance and non-substance addictions -- Traditional Chinese medical therapy for substance and non-substance addictions -- Nutrition support therapy for substance and non-substance addictions -- Psychotherapy for substance and non-substance addictions -- Cognitive-behavioural therapy for substance and non-substance addictions -- Summary and prospect
    Abstract: This book focuses on the similarities and differences between℗ substance and non-substance addictions. It discusses in detail the mechanisms, diagnosis and treatment of℗ substance and non-substance addictions, and addresses selected prospects that will shape future studies on addiction. Addiction is a global problem that costs millions of lives tremendous damage year after year. There are mainly two types of addition: substance addiction (e.g., nicotine, alcohol, cannabis, heroin, stimulants, etc.) and non-substance addiction (e.g., gambling, computer gaming, Internet, etc.). Based on existing evidence, both types of addiction produce negative impacts on individualś€™ physical, mental, social and financial well-being, and share certain common mechanisms, which involve a dysfunction of the neural reward system and specific gene transcription factors. However, there are also key differences between these two types of addiction. Covering these aspects systematically, the book will provide researchers and graduate students alike a better understanding of drug and behavioral addictions
    Pages: XIII, 357 p. 1 illus. in color. : online resource.
    ISBN: 9789811055621
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  • 4
    Publication Date: 2018-03-15
    Description: Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway, Published online: 14 March 2018; doi:10.1038/s41419-018-0428-x Histone deacetylase 3 promotes liver regeneration and liver cancer cells proliferation through signal transducer and activator of transcription 3 signaling pathway
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 5
    Publication Date: 2018-01-19
    Description: Organic Letters DOI: 10.1021/acs.orglett.7b03836
    Print ISSN: 1523-7060
    Electronic ISSN: 1523-7052
    Topics: Chemistry and Pharmacology
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  • 6
    Publication Date: 2018-01-25
    Description: Genes, Vol. 9, Pages 57: Exploring Genomic Variants Related to Residual Feed Intake in Local and Commercial Chickens by Whole Genomic Resequencing Genes doi: 10.3390/genes9020057 Authors: Jie Liu Ranran Liu Jie Wang Yonghong Zhang Siyuan Xing Maiqing Zheng Huanxian Cui Qinghe Li Peng Li Xiaoyan Cui Wei Li Guiping Zhao Jie Wen Improving feed efficiency is a major goal in poultry production to reduce production costs and increase profitability. The genomic variants and possible molecular mechanisms responsible for residual feed intake (RFI) in chickens, however, remain poorly understood. In this study, using both local and commercial breeds, genome re-sequencing of low RFI and high RFI chickens was performed to elucidate the genomic variants underlying RFI. Results showed that 8,505,214 and 8,479,041 single nucleotide polymorphisms (SNPs) were detected in low and high RFI Beijing-You chickens, respectively; 8,352,008 and 8,372,769 SNPs were detected in low- and high-RFI Cobb chickens, respectively. Through a series of filtering processes, 3746 candidate SNPs assigned to 1137 genes in Beijing-You chickens and 575 candidate SNPs (448 genes) in Cobb chickens were found. The validation of the selected 191 SNPs showed that 46 SNPs were significantly associated with the RFI in an independent population of 779 Cobb chickens, suggesting that the method of screening associated SNPs with whole genome sequencing (WGS) strategy was reasonable. Functions annotation of RFI-related genes indicated that genes in Beijing-You were enriched in lipid and carbohydrate metabolism, as well as the phosphatase and tensin homolog (PTEN) signaling pathway. In Cobb, however, RFI-related genes were enriched in the feed behavior process and cAMP responsive element binding protein (CREB) signaling pathway. For both breeds, organismal development physiological processes were enriched. Correspondingly, NOS1, PHKG1, NEU3 and PIP5K1B were differentially expressed in Beijing-You, while CDC42, CSK, PIK3R3, CAMK4 and PLCB4 were differentially expressed in Cobb, suggesting that these might be key genes that contribute to RFI. The results of the present study identified numerous novel SNPs for RFI, which provide candidate biomarkers for use in the genetic selection for RFI. The study has improved knowledge of the genomic variants and potential biological pathways underlying RFI in chickens.
    Electronic ISSN: 2073-4425
    Topics: Biology
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  • 7
    Publication Date: 2018-05-15
    Description: The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity, Published online: 14 May 2018; doi:10.1038/s41419-018-0581-2 The ginsenoside PPD exerts anti-endometriosis effects by suppressing estrogen receptor-mediated inhibition of endometrial stromal cell autophagy and NK cell cytotoxicity
    Electronic ISSN: 2041-4889
    Topics: Biology , Medicine
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  • 8
    Publication Date: 2018-03-17
    Description: Cholesterol biosynthesis is tightly regulated in the cell. For example, high sterol concentrations can stimulate degradation of the rate-limiting cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase, HMGCR). HMGCR is broken down by the endoplasmic reticulum membrane–associated protein complexes consisting of insulin-induced genes (Insigs) and the E3 ubiquitin ligase gp78. Here we found that HMGCR degradation is partially blunted in Chinese hamster ovary (CHO) cells lacking gp78 (gp78-KO). To identify other ubiquitin ligase(s) that may function together with gp78 in triggering HMGCR degradation, we performed a small-scale short hairpin RNA–based screening targeting endoplasmic reticulum–localized E3s. We found that knockdown of both ring finger protein 145 (Rnf145) and gp78 genes abrogates sterol-induced degradation of HMGCR in CHO cells. We also observed that RNF145 interacts with Insig-1 and -2 proteins and ubiquitinates HMGCR. Moreover, the tetrapeptide sequence YLYF in the sterol-sensing domain and the Cys-537 residue in the RING finger domain were essential for RNF145 binding to Insigs and RNF145 E3 activity, respectively. Of note, amino acid substitutions in the YLYF or of Cys-537 completely abolished RNF145-mediated HMGCR degradation. In summary, our study reveals that RNF145, along with gp78, promotes HMGCR degradation in response to elevated sterol levels and identifies residues essential for RNF145 function.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
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  • 9
    ISSN: 1572-9540
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The construction and characteristics of a new detection system are described in the paper. This new detector consists of five wire planes, two of which are anode planes and three of which are cathode planes. Because two MWPC's with different parameters are adopted, the Mössbauer spectra of the conversion electron, resonance scattering γ-ray, Kx-ray and their coincidence spectrum can be recorded separately. The multiple Mössbauer spectra of the surface layer of several samples is shown.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1545-9985
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] The human p100 protein is a vital transcription regulator that increases gene transcription by forming a physical bridge between promoter-specific activators and the basal transcription machinery. Here we demonstrate that the tudor and SN (TSN) domain of p100 interacts with U small nuclear ...
    Type of Medium: Electronic Resource
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