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  • 1
    ISSN: 1613-9674
    Keywords: Radiation therapy ; Bone metastases ; Head and neck cancer ; Pain relief
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To evaluate the efficacy of radiation therapy for pain relief of bone metastases from head and neck cancer, a total of 22 patients with head and neck cancer with 30 metastatic bone lesions treated by radiation therapy at the Cancer Institute Hospital were analyzed. These patients were given a dose of 20 to 50 Gy in 10 to 25 fractions using liniac X-ray or electron beam and were divided into two groups. Group A consisted of 10 patients with tongue cancer (tongue cancer group), and group B consisted of 12 patients other than with tongue cancer (non-tongue cancer group). In group A, of the 6 metastatic lesions treated with over 30 Gy, 17% achieved CR (complete pain relief for more than 3 months), 33% showed PR (over 50% extent pain relief), and 50% NC. While, in group B, of the 17 lesions 35% showed Cr, 53% PR and 12% NC. There was a significant difference in the response rate (50% vs 88%, P〈0.01) of pain relief between the osseous metastases from tongue cancer group and the non-tongue cancer group, although further prospective studies are necessary to elucidate the radiosensitivity of bone metastases in terms of the histologic difference in head and neck cancer patients.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-7089
    Keywords: 67Ga uptake ; ATP metabolism ; Tumor cells ; NaF and ouabain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previously, we reported that the deposition of 67Ga into malignant tumors may be a sensitive index of proliferative activity in tumor cells. For the purpose of elucidation of this hypothesis, we investigated the relationship between the accumulation of 67Ga into malignant tumor cells and the intra cellular ATP metabolism in vitro. The uptake of 67Ga into tumor cells was inhibited by adding NaF which is an inhibitor of ATP production. Furthermore, the uptake of 67Ga into tumor cells was strongly inhibited by adding ouabain which is a specific inhibitor of Na+−K+-ATPase. From these in vitro results, it was concluded that there is a correlation between 67Ga uptake and intra cellular ATP metabolism in tumor cells.
    Type of Medium: Electronic Resource
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