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  • 1
    Call number: G120:246
    Keywords: Pharmacology ; Therapeutics
    Notes: Includes index.
    Pages: xxiii, 2021 p. : ill.
    Edition: 11th ed.
    ISBN: 0071422803
    Signatur Availability
    G120:246 departmental collection or stack – please contact the library
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  • 2
    Call number: QH506:60/568
    Keywords: Neoplastic Stem Cells
    Pages: xv, 283 p. : ill.
    ISBN: 978-1-58829-938-3
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    QH506:60/568 available
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  • 3
    Keywords: Medicine ; Medical parasitology ; Medical virology ; Chemistry ; Emerging infectious diseases ; Biomedicine ; Virology ; Parasitology ; Chemistry/Food Science, general ; Infectious Diseases ; Medicine/Public Health, general ; Springer eBooks
    Description / Table of Contents: Food Safety and Food Security: a One Health Paradigm -- Food safety: at the center of a One Health approach for combating zoonoses.-℗ The importance of a One Health approach to preventing the development and spread of antibiotic resistance.-℗ Bovine spongiform encephalopathy: A tipping point in One Health and food safety.-℗ Pathogenic℗ Escherichia coli and One Health implications -- National Plans for Developing a One Health Approach.-℗ FAO and the One Health approach.-℗ Development of a One Health national capacity in℗ Africa: The Southern African Centre for Infectious Disease Surveillance One Health virtual centre model -- The℗ development of One Health approaches in the Western Pacific -- One Health approach in the South East Asia Region: Opportunities and challenges.-℗ One Health in Mongolia.-℗ One Health New Technologies, New Approaches and How to Implement -- Climate Change and Human Health: A One Health Approach.-Operationalizing One Health: Stone Mountain and beyond.-℗ Building a foundation for 'One Health': an education strategy℗ for enhancing and sustaining national and regional capacity in endemic and emerging zoonotic disease management.-℗ Infections at the animal/human interface: shifting the paradigm from emergency response to prevention at source -- One health from a social-ecological systems perspective: Enriching social and cultural dimensions -- Subject index.℗
    Abstract: The second volume on One Health explains in detail how to implement three key aspects of the One Health paradigḿ€”food safety and security, national plans for a holistic one health approach, and relevant new technologies and approaches. The fourteen chapters, each by an internationally recognized authority, are organized into three sections of four or five chapters each, that break new ground in clarifying precisely how One Health can become an operational reality in local, national and international public health initiatives. Section three begins with an international overview on food safety and security. The importance of a One Heath approach is then explained in relation to four specific problemś€”the growing prevalence of antibiotic resistance, bovine spongiform encephalopathy and pathogenic E.coli. Section four begins with the role of the Food and Agricultural Organization (FAO) in promoting One Health. The formulation and implementation of national plans for implementing the One Health paradigm are then set out for Africa, the Western Pacific, Southeast Asia and Mongolia. The final section of this two volume book is devoted to implementing new technologies and new approaches to One Health. A wide-ranging analysis considers the importance of climate change and a social-ecological systems approach, as well as how to operationalize One Health, how to move from emergency response to prevention at source, and how to implement an educational strategy that builds a foundation for One Health in emerging disease management.℗ It is anticipated that this two volume book will become a benchmark for practitioners of One Health, empowering a balanced multidisciplinary approach to the complexities of the human-animal-environment interface
    Pages: XVII, 235 p. 23 illus., 16 illus. in color. : online resource.
    ISBN: 9783642358463
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  • 4
    Keywords: Medicine ; Pharmaceutical technology ; Biomedicine ; Pharmaceutical Sciences/Technology ; Springer eBooks
    Description / Table of Contents: Pharmaceutical Industry Performance -- Scope: productivity, success rates and costs -- Competitive landscape and regulatory requirements across different geographies. Drivers for increased efficiency, innovative approaches, and outlook for the next decade -- Unmet needs, major therapeutic areas of R&D focus and investment -- New Product Planning: Scope: General overview of patient profiles from different therapeutic areas, competitive intelligence, standard of care considerations, and impact of this information on the definition of NCE and product attributes and timelines -- Discovery Chemistry and Technologies: Scope: The druggable chemistry space, current targets of interest, new discovery technologies to define the binding pockets and compound attributes for a druggable target -- Challenges, examples of innovation and success -- Chemistry (Authors: TBD) -- Biology, genomics, target validation -- In silico tools -- Early Discovery: Target of Interest through Lead: Scope: Effective and dynamic cross-functional collaboration between in vitro biology, chemistry, pharmacology, ADME, preformulation and toxicology to achieve Druggable Leads -- Application of in silico, in vitro and in vivo tools and translational approaches and strategies for integrated assessment and creation of druggable and developable lead scaffolds and assessing affinity and druggability at the scaffold level -- FBDD, druggable scaffolds, hit screening and making compounds -- Integrated assessment of Lead readiness, SRA -- Lead Optimization: Scope: Effective and dynamic cross-functional collaboration between in vitro biology, chemistry, pharmacology, ADME, preformulation and toxicology to achieve target engagement with a druggable candidate -- Candidate Selection -- Application of in silico, in vitro and in vivo tools and translational approaches and strategies for integrated assessment and identification of druggable and developable Clinical Candidate(s) with line of sight for clinical development -- Include description of tools, examples of application/case studies -- Developability including formulations and bio-relevant dissolution -- Chemistry scale up -- Early Clinical Development: Scope: Strategies for clinical trial study designs in the context of different therapeutic areas, clinical formulations, safety margins, biomarkers, tailored therapeutics, PK/PD modeling, controlled release formulations -- John Morrison working out the details of this section -- Alternative Drug Delivery: Scope: non-oral formulations based on patient/caregiver/marketing considerations -- Design, definition of compound attributes and development -- Regulatory aspects -- Industry Academia Collaboration -- Outlook for the Future
    Abstract: Tackling translational medicine with a focus on the drug discovery development-interface, this book integrates approaches and tactics from multiple disciplines, rather than just the pharmaceutical aspect of the field. The authors of each chapter address the paradox between the molecular understanding of diseases, drug discovery, and drug development. Laying out the detailed trends from various fields, different chapters are dedicated to target engagement, toxicological safety assessments, and the compelling relationship of optimizing early clinical studies with design strategies. The book also highlights the importance of balancing the three pillars: sufficient efficacy, acceptable safety and appropriate pharmacokinetics, all of which are crucial to successful efforts in discovery and development. With discussions regarding the combined approaches of molecular research, personalized medicine, pre-clinical and clinical development, as well as targeted therapies—this compendium is a flexible fit, perfect for professionals in the pharmaceutical industry and related academic fields
    Pages: XXIV, 461 p. 101 illus., 81 illus. in color. : online resource.
    ISBN: 9783319500423
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  • 5
    Call number: W26.5:55
    Keywords: Neoplasms ; Clinical Trials / methods ; Medical Informatics
    Pages: xxvi, 377 p.
    ISBN: 0387953280
    Signatur Availability
    W26.5:55 available
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  • 6
    Keywords: Medicine ; Medical parasitology ; Medical virology ; Biomedicine ; Virology ; Parasitology ; Springer eBooks
    Description / Table of Contents: Introduction -- One Health: its origins and its future -- The concept of One Health.-℗ One Health and emerging infectious diseases: clinical perspectives -- The historical, present, and future role of veterinarians in℗ One Health. - The importance of understanding the human-animal interface. - the human environment interface: Applying ecosystem concepts to health -- Wildlife: the need to better understand the linkages -- ℗ The economic value℗ of One Health in relation to the mitigation of zoonotic disease risks. -℗ Examples of a One Health approach to specific diseases from the field -- The application of One Health approaches to henipavirus research. - H5N1 highly pathogenic avian influenza in Indonesia: Retrospective considerations. -℗ Rabies in℗ Asia: the classical zoonosis. -℗ Japanese encephalitis: On the One Health agenda -- Cost estimate of℗ bovine tuberculosis to Ethiopia -- The pandemic℗ H1N1 influenza experience -- One Health: The Hong Kong experience with avian influenza -- Clostridium difficile infection in humans and piglets: a 'One Health' opportunity -- Cysticercosis and Echinococcosis -- Men, primates and germs:℗ an℗ ongoing affair -- Subject index
    Abstract: This volume brings together the concepts that underpin a One Health approach and a range of examples of this approach in action around a variety of emerging infectious diseases. The first section starts with a human clinical perception, brings in the veterinary and human €“ánimal interface perspective and then links this with environment issues, with a special chapter dealing with wildlife. It concludes by looking at the economics of a One Health approach, both in terms of the costs of delivering a One Health approach as well as the value added. The second section looks at a number of key emerging infectious diseases and in each case details how a One Health approach has added value, particularly in terms of disease control and cost outcomes. The examples cover virus, bacterial, protozoal and parasitic infections and provide case studies at the national, regional and global level. The studies themselves vary in depth and detail but provide an engaging set of examples of the value of a One Health approach. In all cases, the authors have local and personal experience of the disease in question, providing real life examples of what can be achieved. The final chapter entitled ́€œMen, primates and germs: an ongoing affaiŕ€ provides a fascinating insight into pathogen host switching between closely related species which serves to illustrate a core value of a One Health approach. ℗
    Pages: X, 362 p. 25 illus., 10 illus. in color. : online resource.
    ISBN: 9783642368899
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  • 7
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: The receiver of the Joint European Torus (JET) energetic ion and alpha particle collective Thomson scattering diagnostic is calibrated assuming blackbody emission from the torus vacuum vessel (VV) and using electron cyclotron emission (ECE). The 32 receiver channels are absolutely calibrated with a mechanical chopper in the quasioptical arm of the receiver, alternating the receiver view between the torus vacuum at 320 °C and room temperature. This calibration is noisy due to the small difference between torus and room temperatures. A more accurate relative calibration is achieved with the ECE during plasma shots. The intensity of the ECE is found to be a smooth function of frequency, which enables the combination of the ECE calibration with the VV calibration. The accuracy of the absolute VV calibration is hereby improved to nearly the same standard as the relative ECE calibration. ECE signals measured by the calibrated receiver agree well with standard JET ECE diagnostics. Based on mathematical considerations presented here, noise is injected into the receiver final intermediate frequency stage during VV calibrations to provide more bit transitions for accurate analog-to-digital (AD) conversion of the low level calibration signals. This yields a resolution which is better than 1% of an (AD) step. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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