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  • 1
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    facet.materialart.
    German Medical Science; Düsseldorf, Köln
    In:  Evidenzbasierte Medizin - Anspruch und Wirklichkeit; 102. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft; 20040923-20040926; Berlin; DOC04dogFR.04.05 /20040922/
    Publication Date: 2004-09-21
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 2
    facet.materialart.
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    German Medical Science; Düsseldorf, Köln
    In:  104. Jahrestagung der Deutschen Ophthalmologischen Gesellschaft (DOG); 20060921-20060924; Berlin; DOC06dogDO.01.03 /20060918/
    Publication Date: 2006-09-19
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 3
    ISSN: 1432-1076
    Keywords: Key words: Retinopathy of prematurity – Bilirubin and anti-oxidant effect
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. The prevention of retinopathy of prematurity (ROP) remains a persistent problem. A previous report has focused on the possible protective effect of bilirubin on the development of ROP. These results still await clinical confirmation by other research groups. Therefore, we undertook a retrospective clinical study trying to confirm this attractive hypothesis. Twelve premature newborns under 32 weeks of gestation with ROP stage 3 – 4 were matched for gestational age with 12 infants without ROP. Data were collected about the infant's characteristics, medical illnesses, ventilatory settings and treatments. The total serum bilirubin concentrations between the 1st and 8th postnatal day were also gathered. The two matched groups were comparable as to their basic data, clinical characteristics and treatment, except for a slight, but significant longer duration of phototherapy for group ROP 0 (mean, 50.2 h; SD 48.6 vs 31.6 h; SD 42.7 in ROP 3 – 4; P=0.02). No statistical difference relative to bilirubin was found between the two groups, neither when expressed as daily mean concentrations, nor as area under the curve (AUC) (mean, ROP 0: 17 876.7; SD 6077.3 vs 18 888.4; SD 55 552.7 in ROP 3 – 4; P=0.404) or AUC/h (mean, ROP 0: 135.1; SD 36.3 vs 144.1; SD 23.2 in ROP 3 – 4; P=0.515). Our findings do not confirm the hypothesis of a clinically measurable, beneficial role of bilirubin on the development of ROP.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2307
    Keywords: Key words Atypical ductal hyperplasia ; Ductal carcinoma in situ ; Estrogen receptor ; Keratin 19 ; Cyclin D1
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Evidence from many studies has established the neoplastic potential of ductal carcinoma in situ, but the origin and the morphological characteristics of the early stages of this proliferation remain unidentified. Workers writing in the early twentieth century observed a cystic transformation of lobules and proposed that it represented one such early stage, and contemporary European and Japanese pathologists have reached the same conclusion. We describe the characteristics of this cystic transformation, which we call us “atypical cystic lobules,” and present evidence to support the proposal that the alteration is a step in the formation of low-grade ductal carcinoma in situ. Atypical cystic lobules are a proliferation of luminal cells showing low-grade cytological atypia without architectural atypia. The study group comprised 21 cases of atypical cystic lobules from specimens also showing conventional low-grade ductal carcinoma in situ or lobular neoplasia. Immunohistochemical staining for hormone receptors, keratin 19, and cyclin D1 revealed that atypical cystic lobules demonstrated a consistent immunophenotype, which differs from the pattern shown by normal lobules and benign lesions and matches that of low-grade ductal carcinoma in situ. In about 40% of the cases, atypical cystic lobules merged with fully established micropapillary/cribriform ductal carcinoma in situ. The similarities in the cytological and immunohistochemical features and the proximity of the two types of proliferation suggest that atypical cystic lobules represent an early stage in the formation of certain types of low-grade ductal carcinoma in situ.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 363 (1974), S. 97-112 
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Samples of solid tumours were obtained from six patients with classical seminoma, either from the center or the periphery of the tumour as well as from macroscopically normal-looking testioular tissue. The tissues were examined by light and electron microscopy. In different places of the affected testis, three different tumour cell types were found: 1. Intratubular, basal tumoral cells showing abondant glycogen, a peripheral web of microfilaments and thin cell expansions. 2. In the periphery of the tumour, cells are found towards the seminiferous tubular lumen, characterized by having less glycogen, many endoplasmic reticulum membranes and free ribosomes and fewer cytoplasmic evaginations. 3. In the center of solid tumours, rounded cells exhibiting neither glycogen nor cell expansions and few figured elements in the cytoplasm are found. The tumour cells of type 1 show characteristics of human embryonic germinal cells, those of type 3 being the more differentiated and forming most of the tumoral mass. Hence classical seminoma is formed not only by large clear cells as stated in the literature, but instead by more cell types, as described in the present work.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 425 (1994), S. 449-457 
    ISSN: 1432-2307
    Keywords: Breast carcinoma ; Neuroendocrine ; Carcinoid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The occurrence of endocrine differentiation in some mammary carcinomas seems well-established, but pathologists continue to debate its significance. Contemporary thinking suggests that endocrine tumours of the breast do not constitute a single clinicopathological entity with a consistent histogenesis but rather that endocrine differentiation represents a pathway of neoplastic development available to a range of breast cancers. This pattern of differentiation occurs in tumours with vastly different morphological appearances, such as: ductal carcinoma in situ, mucinous carcinoma, a variant of lobular carcinoma, and low grade invasive ductal carcinoma. Although such tumours share some characteristics with intestinal endocrine neoplasms, the typical pattern of intestinal carcinoid virtually never occurs in mammary lesions. Conventional microscopy permits the diagnosis in most cases. Specialized techniques (histochemistry, immunohistochemistry, and electron microscopy) can serve as the basis for diagnosis in the absence of the appropriate morphological features. Although the system of nomenclature proposed by the World Health Organization for use with endocrine tumours in other organs can be used for endocrine tumours of the breast, only a minority of lesions will fit the established criteria. Most lesions are classifiable in the conventional categories of mammary carcinomas. No special prognostic significance is attached to these tumours at the present time.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Virchows Archiv 428 (1996), S. 319-324 
    ISSN: 1432-2307
    Keywords: Breast ; Neoplasm ; Neuroendocrine ; Spindle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We report the pathological characteristics of a variant of mammary endocrine tumour, predominantly formed from cytologically bland spindle cells. This neoplasm grows as a red, well defined mass lacking the usual macroscopical characteristics of breast cancer. Within smoothly contoured aggregates arranged in an insular pattern, delicate capillaries and collagen bundles support the neoplastic epithelial cells. Most of the tumour cells possess a slender spindle shape and form a solid or fenestrated sheet, but a few appear cuboidal and create glands. Immunohistochemical studies demonstrate that the spindle cells and the glandular cells constitute a single population. Both types of cells stain for neuroendocrine markers (chromogranin, synaptophysin, and CD 57), carcinoembryonic antigen, keratin 8/18, S-100 protein, and receptors for oestrogen and progesterone. Many of the tumour cells possess argyrophilic granules, and electron microscopy may reveal dense core granules.
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Urological research 3 (1975), S. 91-94 
    ISSN: 1434-0879
    Keywords: Hydronephrotic kidneys ; mechanical load capacity ; kidney rupture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The hydrostatic pressure, intrapelvic volume, and specific elasticity and strength of strips of tissue from the parenchyma and the pelvis of eight hydronephrotic kidneys were investigated and compared with the tissue characteristics of the pelvis of four control kidneys. Hydronephrosis manifested itself by a sixfold reduction of tissue strength, and dynamically by a ninefold reduction of the energy absorptive capacity of the parenchyma as compared with the pelvis. Its further response to trauma appeared to be influenced by internal pressure, the law of mass variation, and the energy absorptive capacity of surrounding anatomical structures. The vulnerability of the hydronephrotic kidney in situ depends on its volume and topography, the parenchyma being the part that may be regarded as the site most predisposed to rupture.
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  • 9
    ISSN: 1433-8491
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Ein nicht obduzierter Fall visueller Agnosie mit irreversibler corticaler Farbenblindheit, Prosopagnosie und leichter Orientierungsstörung im Raum wird beschrieben. Der Verlauf konnte über 5 Jahre beobachtet werden. Ursächlich werden embolisch entstandene, bilaterale Läsionen im Occipitalbereich angenommen. Mit Fällen anderer Autoren wird zum Agnosieproblem und seinen unterschiedlichen Interpretationen Stellung genommen. Obwohl Begriff und Deutung der Agnosie umstritten sind und vielfach abgelehnt werden, scheint es gerechtfertigt, klinisch typische visuell-agnostische Syndrome als Agnosie zu bezeichnen. Es ist möglich, diese einer bestimmten Hemisphäre der hinteren Großhirnanteile zuzuordnen. Das Erkennen von Gesicht und Raum kann ungeachtet der Hemisphärendominanz bevorzugt an die rechte Hemisphäre gebunden sein. Unser Fall ist ein weiteres Beispiel für die isolierte Vulnerabilität dieser individuellen gnostischen Leistungen. Die Kombination mit einer corticalen Farbsinnstörung bei Restitution aller Symbolleistungen ist eine selten beobachtete Besonderheit bei speziell angeordneten Herden in beiden Occipitallappen.
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Journal of fish biology 65 (2004), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: A long-term swim trial was performed with five female silver eels Anguilla anguilla of 0·8–1·0 kg (c. 80 cm total length, LT) swimming at 0·5 body lengths (BL) s−1, corresponding to the mean swimming speed during spawning migration. The design of the Blazka-type swim tunnel was significantly improved, and for the first time the flow pattern of a swim tunnel for fish was evaluated with the Laser-Doppler method. The velocity profile over three different cross-sections was determined. It was observed that 80% of the water velocity drop-off occurred over a boundary layer of 20 mm. Therefore, swim velocity errors were negligible as the eels always swam outside this layer. The fish were able to swim continuously day and night during a period of 3 months in the swim tunnel through which fresh water at 19° C was passed. The oxygen consumption rates remained stable at 36·9 ± 2·9 mg O2 kg−1 h−1 over the 3 months swimming period for all tested eels. The mean cost of transportation was 28·2 mg O2 kg−1 km−1. From the total energy consumption the calculated decline in fat content was 30%. When extrapolating to 6000 km this would have been 60%, leaving only 40% of the total energy reserves for reproduction after arriving at the spawning site. Therefore low cost of transport combined with high fat content are crucial for the capacity of the eel to cross the Atlantic Ocean and reproduce.
    Type of Medium: Electronic Resource
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