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  • 1
    Publication Date: 2018-04-06
    Description: Objectives To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. Design Observational cohort study. Setting 146 mainly secondary care centres across England and Wales. Participants 3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network. 3021 were of white European ethnicity and 291 (9%) were non-white. There was a small male predominance (57%). Young people 〈17 years comprised 59%. Main outcome measures Autoantibody status and characteristics at presentation. Results The majority presented with classical osmotic symptoms, weight loss and fatigue. Ketoacidosis was common (42%), especially in adults, and irrespective of ethnicity. 35% were overweight or obese. Of the 1778 participants who donated a blood sample, 85% were positive for one or more autoantibodies against glutamate decarboxylase, islet antigen-2 and zinc transporter 8. Presenting symptoms were similar in the autoantibody-positive and autoantibody-negative participants, as was the frequency of ketoacidosis (43%vs40%, P=0.3). Autoantibody positivity was less common with increasing age (P=0.0001), in males compared with females (82%vs90%, P〈0.0001) and in people of non-white compared with white ethnicity (73%vs86%, P〈0.0001). Body mass index was higher in autoantibody-negative adults than autoantibody-positive adults (median, IQR 25.5, 23.1–29.2vs23.9, 21.4–26.7 kg/m 2 ; P=0.0001). Autoantibody-negative participants were more likely to have a parent with diabetes (28%vs16%, P〈0.0001) and less likely to have another autoimmune disease (4%vs8%, P=0.01). Conclusions Most people assigned a diagnosis of type 1 diabetes presented with classical clinical features and islet autoantibodies. Although indistinguishable at an individual level, autoantibody-negative participants as a group demonstrated features more typically associated with other diabetes subtypes. Trial registration number ISRCTN66496918 ; Pre-results.
    Keywords: Open access, Diabetes and Endocrinology, Epidemiology
    Electronic ISSN: 2044-6055
    Topics: Medicine
    Published by BMJ Publishing
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  • 2
    Call number: M120:299
    Pages: x, 219 p. : ill.
    ISBN: 9783527342037
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    M120:299 departmental collection or stack – please contact the library
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  • 3
    Call number: 2020:64
    Keywords: Diagnostic bacteriology / Handbooks, manuals, etc ; Bacteria / Classification ; BAKTERIUM / SYSTEMATIK ; Mikrobiologie / Arbeitsmethodik
    Pages: xix, 331 p. : ill.
    Edition: 3rd ed. / edited and rev. by G.I. Barrow and R.K.A. Feltham.
    ISBN: 0521326117
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  • 4
    Call number: QZ241:3(2)/19
    Keywords: Respiratory organs / Tumors ; Ear / Tumors ; Tumors / Classification ; Ear Neoplasms / classification ; Ear Neoplasms / pathology ; Respiratory Tract Neoplasms / classification ; Respiratory Tract Neoplasms / pathology
    Notes: Rev. ed. of: Histological typing of upper respiratory tract tumours. 1978.
    Pages: x, 201 p. : col. ill.
    Edition: 2nd ed.
    ISBN: 3540538801
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  • 5
    Unknown
    Philadelphia : Wolters Kluwer Health/Lippincott Williams & Wilkins
    Call number: QZ365WI200:90(4)
    Keywords: Head / Cancer ; Neck / Cancer ; Head and Neck Neoplasms / radiotherapy ; Radiotherapy / methods
    Description / Table of Contents: Overview of recent advances -- Modes of therapy -- Practical aspects of external beam therapy -- Practical aspects of endocavitary beam therapy and brachytherapy -- Patient care before and during radiotherapy -- Oral cavity -- Nasopharynx -- Oropharynx -- Larynx -- Hypopharynx -- Nasal cavity -- Paranasal sinuses -- Salivary glands -- Thyroid -- Skin -- Neck node metastasis from unknown primary -- Treatment of local-regional recurrence
    Notes: For online access to this volume please contact the library staff in room D124 (phone 3661, e-mail: http://www.dkfz.de/de/zbib/mitarbeiter/kontakt/fernleihe.php
    Pages: 191 p.
    Edition: 4th ed.
    ISBN: 9781608316861
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  • 6
    Call number: F065:4
    Keywords: Polymerase Chain Reaction / methods
    Description / Table of Contents: Introduction to the polymerase chain reaction / Y.M. Dennis Lo and K.C. Allen Chan -- Setting up a polymerase chain reaction laboratory / Y.M. Dennis Lo and K.C. Allen Chan -- Real time polymerase chain reaction and melting curve analysis / Robert J. Pryor and Carl T. Wittwer -- Qualitative and quantitative polymerase chain reaction-based methods for DNA methylation analyses / Ivy H.N. Wong -- In-cell polymerase chain reaction: strategy and diagnostic applications / T. Vauvert Hviid -- Qualitative and quantitative DNA and RNA analysis by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry / Chunming Ding -- Analysis of polymerase chain reaction products by denaturing high performance liquid chromatography / Ching-Wan Lam -- Use of real time polymerase chain reaction for the detection of fetal aneuploidies / Bernhard Zimmermann ... [et al.] -- Noninvasive prenatal diagnosis by analysis of fetal DNA in maternal plasma / Rossa W. K. Chiu and Y. M. Dennis Lo --
    Pages: x, 200 p. : ill.
    Edition: 2nd ed.
    ISBN: 1588293483
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  • 7
    Unknown
    Oxford : Oxford University Press
    Call number: 05-MET-15:55 ; 05-MET-15:55a
    Keywords: Nuclear magnetic resonance spectroscopy
    Notes: Cataloging based on CIP data.
    Pages: p.
    ISBN: 0198551916
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  • 8
    Keywords: Life sciences ; Biotechnology ; Agriculture ; Plant Biochemistry ; Microbial ecology ; Life sciences ; Plant Biochemistry ; Microbial ecology ; Agriculture ; Biotechnology ; Springer eBooks
    Description / Table of Contents: 1. Endophytic in Agrobiology: An Introduction -- PART 1: Crop Productivity -- 2. Role of Endophytic Bacteria on the Crop Productivity and Soil Health -- 3. Plant Growth Promotion by Endophytic Bacteria in Non-Indigenous Crops -- 4. Role of Endophytic Fungi in Agricultural Productivity -- 5. Endophytic Bacteria: Role in Phosphate Solubilization -- 6. Phytohormone Production from Edophytic Bacteria and Their Application in Plant Growth Promotion -- 7. Beneficial Effects of Bacterial Endophytes on Forest Tree Species -- 8. Role of Bacterial Endophytes in Plant Disease Control -- 9. Endophytic Actinomycetes for Sustainable Agricultural Applications -- PART 2: Metabolites Production -- 10. Endophytic Fungi: A Remarkable Source of Biologically Active Scondary Metabolites -- 11. Endophytes: Potential Source of Therpeuatically Important Secondary Metabolites of Plant Origin -- 12. Endophytic Microorganisms: Source of Volatile Organic Compounds for Improvement of Plant Health -- 13. Potential of Endophytic Lignin Degrading Fungi: Role on Lignocellulosic Biorefineries -- 14. Conclusion -- Index
    Abstract: This book reviews the latest developments in our understanding of microbial endophytes and their potential applications in enhancing productivity and disease protection. It covers all the latest discoveries regarding endophytes, their interactions with plants and application in agricultural productivity and protection.℗ Our understanding of endophytes has increased exponentially in recent decades. These microbes, such as fungi, bacteria, and actinobacteria, establish a symbiotic or parasitic association with plants. A better understanding of endophytic microorganisms may help to elucidate their functions and potential role in developing sustainable systems of crop production and improved protection against biotic stresses. Endophytes play a vital role in plant growth and health promotion. Endophytic bacteria are of agrobiological interest because they create host-endophyte relationships, which can open exciting prospects for newer biotechnological applications. Endophytes have also proven to be a beneficial and sustainable alternative to agrochemicals due to their role in the biocontrol of pests and diseases. Further, endophytes are essential to the production of several secondary metabolites in grasses, in the process of gummosis in trees, and the production of useful metabolites such as alkaloids, pestaloside, cryptocandin, enfumafungin, subglutinols, etc. for the host plant. They are also involved in the production of enzymes, biosurfactants, biocontrol agents and plant growth promoters. As such, it is imperative that we explore these productś€™ industrial applications in the fields of biotechnology, pharmacy and agriculture. This volume will offers a valuable guidance for botanists, microbiologists, biotechnologists, molecular biologists, environmentalists, policymakers, conservationists, and those working for the protection of plant species of agricultural and medicinal importance
    Pages: XI, 291 p. 70 illus. : online resource.
    ISBN: 9783319665443
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  • 9
    Call number: WI301:7
    Keywords: Duodenum / pathology ; Stomach / pathology ; Diagnostic Imaging ; Duodenal Diseases / diagnosis ; Stomach Diseases / diagnosis
    Pages: x, 262 p. : ill.
    ISBN: 9783540424628
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    WI301:7 available
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  • 10
    Keywords: Life sciences ; Communication ; Library Science ; Mass Media ; Law ; Life sciences ; Life Sciences, general ; Media and Communication ; Popular Life Sciences ; Library Science ; Media Law ; Springer eBooks
    Description / Table of Contents: Preface -- Scientific Scholarly Communication: Moving Forward Through Open Discussions -- Access to Scientific Knowledge: A Historical Perspective -- On the Road to Unrestricted Access to Scientific Information: The Open Access Movement -- Sharing Scientific Data: Moving Towards "Open Data?" -- Free Flow of Scientific Information vs. Intellectual Property Rights -- Preserving the Quality of Scientific Research: Peer Review of Research Articles -- Measuring the Impact of Scientific Research -- Assessing the Societal Impact of Scientific Research -- Final Thoughts: Scientific Scholarly Communication - The March Forward
    Abstract: This book critically examines the historical developments and current trends in the scientific scholarly communication system, issues and challenges in scientific scholarly publishing and scientific data sharing, implications and debates associated with the influence of intellectual property rights on scientific information sharing, and new trends related to peer reviewing and measuring the impact of scientific publications. Based on thorough examination of published literature, the book illustrates the involvement of many stakeholderś€”scientists, science educators, university administrators, government entities, research funders, and other interested parties€”ín this complex and dynamic system. The discussion highlights the roles these stakeholders have to play, individually and collaboratively, to help transform the future of the scientific scholarly communication system
    Pages: X, 140 p. 2 illus. in color. : online resource.
    ISBN: 9783319506272
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