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  • 1
    Publication Date: 2018-06-19
    Description: IL-36α (gene symbol Il1f6 ), a member of the IL-36 family, is closely associated with inflammatory diseases, including colitis and psoriasis. In this study, we found that Il1f6 –/– mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas Il1f6 –/– mice showed similar susceptibility to dextran sodium sulfate–induced colitis to wild-type mice. These effects were observed in both cohoused and separately housed conditions, and antibiotic treatment did not cancel the resistance of Il1f6 –/– mice to imiquimod-induced dermatitis. Bone marrow (BM) cell transfer revealed that IL-36α expression in skin-resident cells is important for the pathogenesis of dermatitis in these mice. Following stimulation with IL-36α, the expression of Il1f6 and Il1f9 (IL-36), but not Il1f8 (IL-36β), was enhanced in murine BM-derived Langerhans cells (BMLCs) and murine primary keratinocytes but not in fibroblasts from mice. Upon stimulation with agonistic ligands of TLRs and C-type lectin receptors (CLRs), Il1f6 expression was induced in BMLCs and BM-derived dendritic cells. Furthermore, IL-36α stimulation resulted in significantly increased gene expression of psoriasis-associated Th17-related cytokines and chemokines such as IL-1α, IL-1β, IL-23, CXCL1, and CXCL2 in BMLCs and fibroblasts, and IL-1α, IL-1β, IL-17C, and CXCL2 in keratinocytes. Collectively, these results suggest that TLR/CLR signaling–induced IL-36α plays an important role for the development of psoriasiform dermatitis by enhancing Th17-related cytokine/chemokine production in skin-resident cells via a local autoamplification loop.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
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  • 2
    Publication Date: 2011-04-08
    Description: Regulatory mechanisms governing the sequence from progenitor cell proliferation to neuronal migration during corticogenesis are poorly understood. Here we report that phosphorylation of DISC1, a major susceptibility factor for several mental disorders, acts as a molecular switch from maintaining proliferation of mitotic progenitor cells to activating migration of postmitotic neurons in mice. Unphosphorylated DISC1 regulates canonical Wnt signalling via an interaction with GSK3beta, whereas specific phosphorylation at serine 710 (S710) triggers the recruitment of Bardet-Biedl syndrome (BBS) proteins to the centrosome. In support of this model, loss of BBS1 leads to defects in migration, but not proliferation, whereas DISC1 knockdown leads to deficits in both. A phospho-dead mutant can only rescue proliferation, whereas a phospho-mimic mutant rescues exclusively migration defects. These data highlight a dual role for DISC1 in corticogenesis and indicate that phosphorylation of this protein at S710 activates a key developmental switch.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088774/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3088774/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishizuka, Koko -- Kamiya, Atsushi -- Oh, Edwin C -- Kanki, Hiroaki -- Seshadri, Saurav -- Robinson, Jon F -- Murdoch, Hannah -- Dunlop, Allan J -- Kubo, Ken-ichiro -- Furukori, Keiko -- Huang, Beverly -- Zeledon, Mariela -- Hayashi-Takagi, Akiko -- Okano, Hideyuki -- Nakajima, Kazunori -- Houslay, Miles D -- Katsanis, Nicholas -- Sawa, Akira -- DK-072301/DK/NIDDK NIH HHS/ -- DK-075972/DK/NIDDK NIH HHS/ -- G0600765/Medical Research Council/United Kingdom -- HD-04260/HD/NICHD NIH HHS/ -- MH-069853/MH/NIMH NIH HHS/ -- MH-084018/MH/NIMH NIH HHS/ -- MH-085226/MH/NIMH NIH HHS/ -- MH-088753/MH/NIMH NIH HHS/ -- MH-091230/MH/NIMH NIH HHS/ -- R01 DK072301/DK/NIDDK NIH HHS/ -- R01 DK075972/DK/NIDDK NIH HHS/ -- R01 DK075972-06/DK/NIDDK NIH HHS/ -- R01 HD042601/HD/NICHD NIH HHS/ -- R01 HD042601-10/HD/NICHD NIH HHS/ -- R01 MH091230/MH/NIMH NIH HHS/ -- R01 MH092443/MH/NIMH NIH HHS/ -- England -- Nature. 2011 May 5;473(7345):92-6. doi: 10.1038/nature09859. Epub 2011 Apr 6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21471969" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; COS Cells ; Cell Movement/genetics ; Cell Proliferation ; Cercopithecus aethiops ; Cerebral Cortex/cytology/*embryology/physiology ; Gene Knockdown Techniques ; Glycogen Synthase Kinase 3/metabolism ; HEK293 Cells ; Humans ; Mice ; Microtubule-Associated Proteins/genetics/metabolism ; *Nerve Tissue Proteins/genetics/metabolism ; Neurons/*cytology/metabolism/*physiology ; PC12 Cells ; Phosphorylation ; Protein Binding ; Rats ; Signal Transduction ; Stem Cells/*cytology ; Wnt Proteins/metabolism ; beta Catenin/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS); 20120613-20120616; Leipzig; DOCDO.13.07 /20120604/
    Publication Date: 2012-06-05
    Keywords: Endoscope ; Cervical radiculopathy ; Foraminoplasty ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS); 20120613-20120616; Leipzig; DOCFR.03.08 /20120604/
    Publication Date: 2012-06-05
    Keywords: Endoscope ; Cervical stenosis ; Myelopathy ; ddc: 610
    Language: English
    Type: conferenceObject
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 262 (1973), S. 439-450 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract DWBA formulation of the two-nucleon transfer reactions between heavy ions is presented, neglecting the recoil effect. The perturbation is assumed to act between the core and each of the transferred pair. When we approximate the interaction so as to act between the core and the c. m. of the pair, we can extend the method commonly used in analysing (t, p) and (p, t) reactions. Integrals appearing in the DWBA form factor are evaluated exactly. Calculations are compared with the experimental data in the case of the26Mg(18O,16O)28Mg reaction.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The two-neutron transfer reactionASn(18O,16O)A+2Sn has been measured for the isotopes A=112, 116, 118, 120, 122 and 124 at bombarding energies of 57 and 60 MeV together with the elastic scattering. Angular distributions have been analysed for the transitions to the ground state and to the first excited 2+ state. The observed ground state transition is strongly enhanced. The theoretical DWBA analysis is performed with a finite range 2n-transfer form factor including recoil correction. The calculated cross section reproduces the observed systematic change over all isotopes. The absolute cross sections are normalized by a factor of 4.7 and 7.5, depending on the two different sets of 2n-wave functions used in the analysis. The results confirm the prediction of the pairing model that the transition strengths of a neutron pair between the ground states of even tin isotopes are the same.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study quantum effects in a system of S = 1/2 spins with two–, three and four–spin exchange interactions on the triangular lattice, a possible model of the nuclear magnetism of solid 3 He layers. The ground state phases found in our previous work are studied by using the linear spin–wave theory. The “uuud” state shows a very flat spin–wave dispersion, which suggests that this state, though locally stable, will not survive non–linear quantum effects. The “tetrahedral” state, which has long–range order of a scalar chirality, is found to be stable against spin wave fluctuations. The ground state energies of different phases are compared. Results of numerical analysis of finite size clusters are also presented.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We study a Hamiltonian of S = 1/2 spins with two-, three and four-spin exchange interactions on the triangular lattice as a possible model of the nuclear magnetism of solid 3 He layers. The spin wave theory shows that the “tetrahedral” ground state, which was shown to be favoured by the four-spin exchange interaction in our previous paper, is stable against quantum fluctuations in some parameter region. Since this state has a scalar chiral long-range order, a phase transition occurs at a finite temperature even though the Hamiltonian has a full rotational symmetry in the spin space. Critical behavior of this phase transition was examined by classical Monte Carlo simulations. The specific heat diverges much more strongly than that of the 2D Ising model.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We raise and discuss the following question. Why does the spectrum for the three-band model of Hybertson, Stechel, Schluter, and Jennison, claimed not to be approachable by perturbation theory because of rather large hopping integrals compared to site energy differences, follow precisely what would be expected by low-order perturbation theory? The latter is, for the insulating case, that the low-lying levels are describable by a Heisenberg Hamiltonian with nearest-neighbor interactions plus much smaller next-nearest-neighbor interactions and n-spin terms, n≥4. We first check whether perturbation theory actually does not converge, treating the hopping and p-d exchange terms as perturbations. For the crystal, we find that the first three terms contributing to the nearest-neighbor exchange coupling J (which are of third, fourth, and fifth order) increase in magnitude, and are not of the same sign, i.e., there is no sign of convergence to this order. We also consider the small cluster, Cu2O7, for which we have carried out the perturbation series to 14th order; there is still no sign of convergence. Thus the nonconvergence of this straightforward perturbation theory is convincingly established. Yet the apparent perturbative nature of the spectrum suggests the existence of some perturbation theory that does converge. The possibility of a particular transformation of the Hamiltonian leading to a convergent perturbation series, thereby answering the above question, is discussed. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1084
    Keywords: Digital radiography ; Image processing ; Subtraction ; Thorax ; Tomography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Digital tomosynthesis makes it possible to reconstruct multiple tomographs from digital data obtained during a single tomographic motion and permits digital processing, which adds a number of special advantages to the well-known advantages of conventional tomography. We performed digital tomosynthesis with a fluororadiographic TV unit with tomographic function which was capable of producing pulsed low-and high-energy X-rays alternately, and we studied digital image processing to improve the image clarity of the reconstructed tomographs. To identify the optimal parameters for processing image data by means of spatial frequency filtration we evaluated the spatial frequency distribution of image data in linear tomographs of the lung, and on the basis of the results of this study we developed several types of digital image processing to reduce tomographic blur and system noise, to improve visualisation of faint opacities, to reduce resistant tomographic blur as well as overall blur, and to generate low-noise bone images based on dual-energy subtraction tomosynthesis.
    Type of Medium: Electronic Resource
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