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  • 1
    Call number: YY Diss Zhan/Mag
    Keywords: DKFZ-publications / academic dissertations
    Notes: Thesis (MD) -- Ruprecht-Karls-Universität, Heidelberg, 2010.
    Pages: 93 p.
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  • 2
    Unknown
    Dordrecht : Springer Netherlands
    Keywords: Life sciences ; Microbial ecology ; Molecular ecology ; Evolution (Biology) ; Entomology ; Environmental toxicology ; Life sciences ; Fungus Genetics ; Evolutionary Biology ; Ecotoxicology ; Molecular ecology ; Microbial ecology ; Springer eBooks
    Description / Table of Contents: Preface -- Abstract -- 1. Nematode-Trapping Fungi -- 2. Methodology for Studying Nematophagous Fungi -- 3. Taxonomy of Nematode-Trapping Fungi from Orbiliaceae, Ascomycota -- 4. The Ecology of Nematophagous Fungi in Natural Environments -- 5. Biological Control of Plant-Parasitic Nematodes by Nematophagous Fungi -- 6. Molecular Mechanism of Nematophagous Fungi Infection of Nematodes -- 7. Nematode-Toxic Fungi and their Nematicidal Metabolites -- 8. Future Study -- Index
    Abstract: These chapters provide up-to-date information on nematophagous fungi, particularly those of the Orbiliaceae in Ascomycota, whose asexual states produce nematode-trapping devices. The authors consider fungal-nematode interactions, fossil fungi, the biodiversity, ecology and geographical distribution of nematode-trapping fungi, and their potential use in biocontrol of nematodes, all in detail. Nematode-trapping fungi with adhesive or mechanical hyphal traps are the main focus of this book which begins with an overview of the data on nematode-trapping fungi, including their taxonomy, phylogeny and evolution. Subsequent chapters expand upon the methods and techniques used to study these fascinating fungi. Keys for genera of Arthrobotrys, Drechslerella and Dactylellina, which include all reported species of predatory orbiliaceous fungi are presented, and numerous species from these genera are morphologically described and illustrated. The ecology of nematode-trapping fungi is expertly presented: their occurrence and habitats, their geographical and seasonal distribution and the effects of soil conditions and nematode density on their distribution all feature amongst the relevant themes. Further chapters examine the use of nematode-trapping fungi in biological control and the authors consider nematicidal activities in detail, exploring the many compounds from fungi that feature in nematicidal activities and of course useful paths for further study on this topic. This is a highly informative and carefully presented book, providing scientific insight for scholars with an interest in fungi, and in biological control of nematodes
    Pages: XI, 392 p. 137 illus., 14 illus. in color. : online resource.
    ISBN: 9789401787307
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  • 3
    Keywords: Medicine ; Cancer Research ; Medical Microbiology ; Parasitology ; Virology ; Biomedicine ; Cancer Research ; Medical Microbiology ; Virology ; Parasitology ; Springer eBooks
    Abstract: This book offers a state-of-the-art report on recent discoveries concerning viral, bacterial, and parasite infectious cancers. Cancer is one of the most common causes of death and diseases in human populations, and 15%-25% of human cancers in worldwide are considered to result from chronic infection by pathogens. Most oncology textbooks address genetic mutation, but not infectious agents such as viruses, bacteria and parasites. As such this book stimulates further research in the new area between cancers and chronic infection, and discusses the epidemiology and molecular biology of infectious causes of cancers. It also explores the prevention and treatment of infection-related cancers, and brings pathogenic research to the forefront in the never-ending endeavor to understand how pathogens maneuver and negotiate in a complex environment, including the micro/macro- environment of the human host. Further, it highlights the urgent need for a concerted program to develop vaccines and other diagnosis and interventions that will eventually help prevent and treat infectious cancers, and decrease their burden on human populations. It offers graduate students and researchers a comprehensive overview of the infectious causes of cancers
    Pages: XII, 271 p. 18 illus. in color. : online resource.
    ISBN: 9789811057656
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  • 4
    Keywords: Life sciences ; Neurosciences ; Biochemistry ; Cytology ; Cell Membranes ; Neurobiology ; Life sciences ; Neurobiology ; Neurosciences ; Animal Biochemistry ; Cell Physiology ; Membrane Biology ; Springer eBooks
    Abstract: In 1961, neurobiologists found that the conduction velocity of the nerve impulse in the giant nerve fiber of the Penaeus shrimp abdominal nerve cord was over 200 m/s, the highest speed of information transmission ever observed in the animal kingdom. The peculiar myelin sheath with its unique nodal structure and the electrical properties of the nerve fibers of the shrimp have continued to be investigated for a quarter of century and are now fully described in this book. The investigation dispels the commonly held belief that the fastest recorded impulse conduction is about 120 m/s in the thickest vertebrate myelinated nerve fibers. In the shrimp, researchers found a completely novel type of functional node in the giant fiber which they designated as the fenestration node. In portions of the myelinated fiber, the fenestration node furnished the sites of excitation. Also discovered was a new strategy for increasing impulse conduction in the shrimp. The book includes a section on the formation of the fenestration node and the discovery of a strategy that allows the shrimp to escape its predators by an action of the fastest velocity. The data presented in this volume on the myelin sheath of invertebrates present a new direction for this field and a rich source of information for neurobiologists worldwide
    Pages: XVIII, 110 p. 50 illus. : online resource.
    ISBN: 9784431539247
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  • 5
    Keywords: Medicine ; Biochemistry ; Biology / Data processing ; Biomedicine ; Biomedicine general ; Protein Science ; Computer Appl. in Life Sciences ; Springer eBooks
    Description / Table of Contents: Protein folding simulations by generalized-ensemble algorithms -- Application of Markov State Models to Simulate Long Timescale Dynamics of Biological Macromolecules -- Understanding protein dynamics using conformational ensembles -- Generative Models of Conformational Dynamics -- Generalized spring tensor models for protein fluctuation dynamics and conformation changes -- The Joys and Perils of Flexible Fitting -- Coarse-Grained Models of the Proteins Backbone Conformational Dynamics -- Simulating protein folding in different environmental conditions -- Simulating the peptide folding kinetic related spectra based on the Markov State Model -- The Dilemma of Conformational Dynamics in Enzyme Catalysis: Perspectives from Theory and Experiment -- Exploiting protein intrinsic flexibility in drug design -- NMR and computational methods in the structural and dynamic characterization of ligand-receptor interactions -- Molecular Dynamics Simulation of Membrane Proteins -- Free-energy landscape of intrinsically disordered proteins investigated by all-atom multicanonical molecular dynamics -- Coordination and control inside simple biomolecular machines -- Multi-state Targeting Machinery Govern the Fidelity and Efficiency of Protein Localization -- Molecular dynamics simulations of F1-ATPase -- Chemosensorial G-proteins-coupled receptors: a perspective from computational methods
    Abstract: This book discusses how biological molecules exert their function and regulate biological processes, with a clear focus on how conformational dynamics of proteins are critical in℗ this respect. In the last decade, the advancements in computational biology, nuclear magnetic resonance including paramagnetic relaxation enhancement, and fluorescence-based ensemble/single-molecule techniques have shown that biological molecules (proteins, DNAs and RNAs) fluctuate under equilibrium conditions. The conformational and energetic spaces that these fluctuations explore likely contain active conformations that are critical for their function. More interestingly, these fluctuations can respond actively to external cues, which introduces layers of tight regulation on the biological processes that they dictate. A growing number of studies have suggested that conformational dynamics of proteins govern their role in regulating biological functions, examples of this regulation can be found in signal transduction, molecular recognition, apoptosis, protein / ion / other molecules translocation and gene expression. ℗ On the experimental side, the technical advances have offered deep insights into the conformational motions of a number of proteins. These studies greatly enrich our knowledge of the interplay between structure and function. ℗ On the theoretical side, novel approaches and detailed computational simulations have provided powerful tools in the study of enzyme catalysis, protein / drug design, protein / ion / other molecule translocation and protein folding/aggregation, to name but a few. This work contains detailed information, not only on the conformational motions of biological systems, but also on the potential governing forces of conformational dynamics (transient interactions, chemical and physical origins, thermodynamic properties). New developments in computational simulations will greatly enhance our understanding of how these molecules function in various biological events
    Pages: XII, 488 p. 123 illus., 102 illus. in color. : online resource.
    ISBN: 9783319029702
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  • 6
    Keywords: Medicine ; Human Genetics ; Biomedicine ; Human Genetics ; Springer eBooks
    Description / Table of Contents: Designed 3D DNA Crystals -- Three-Dimensional DNA Nanostructures Assembled from DNA Star Motifs -- Design of Wireframe DNA Nanostructures-DNA Gridiron -- Complex DNA Brick Assembly -- Computer-Aided Design of RNA Origami Structures -- Assembling RNA Nanoparticles -- DNA Functionalization of Nanoparticles -- Purification Techniques for Three-Dimensional DNA Nanostructures -- DNA Nanostructure as Smart Carriers for Drug Delivery -- DNA G-Quadruplex-Based Assay of Enzyme Activity -- Assembly of Multi-Enzyme Cascade on a DNA Origami Nanostructure -- Lipid Membrane Encapsulation of a 3D DNA NanoOctahedron -- DNA-PAINT Super-Resolution Imaging for Nucleic Acid Nanostructures -- Designing DNA Nanotube Liquid Crystals as a Weak-Alignment Medium for NMR Structure Determination of Membrane Proteins -- Direct Nanofabrication Using DNA Nanostructure -- Confined Growth of Metal Nanoparticles Within 3D DNA Origami Molds -- DNA-Directed Self-Assembly of Highly Ordered and Dense Single Walled Carbon Nanotube Arrays -- A Proximity-Based Programmable DNA Nanoscale Assembly Line -- DNA Walkers as Transport Vehicles of Nanoparticles Along a Carbon Nanotube Track
    Abstract: This detailed volume presents a comprehensive technical overview of DNA nanotechnology with an emphasis on 3D DNA nanostructure design and applications. Coverage spans from basic design principles for DNA and RNA nanostructures to their cutting-edge applications in a variety of fields, with the book divided into basic DNA and RNA nanostructure design strategies as well as applications utilizing DNA nanostructures, including but not limited to nanomedicine, bioimaging, biosensing, nanoplasmonics, nanoelectronics, nanofabrication, crystallography, biophysics, and analytical chemistry. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and authoritative, 3D DNA Nanostructure: Methods and Protocols provides the most up-to-date tutorial style overviews and technical style protocols to benefit researchers in a wide variety of areas
    Pages: XI, 282 p. 80 illus., 75 illus. in color. : online resource.
    ISBN: 9781493964543
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  • 7
    Keywords: CANCER ; POPULATION ; RISK ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; FOLLICULAR LYMPHOMA ; TUMORIGENESIS ; NON-HODGKIN-LYMPHOMA ; COMMON VARIANTS ; NECROSIS-FACTOR TNF ; RAL GTPASES
    Abstract: Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 x 10-21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 x 10-10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 x 10-8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 x 10-13 and 3.63 x 10-11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.
    Type of Publication: Journal article published
    PubMed ID: 25261932
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  • 8
    Keywords: CLASSIFICATION ; GENE-EXPRESSION ; FOLLICULAR LYMPHOMA ; RHEUMATOID-ARTHRITIS ; GASTRIC LYMPHOMA ; susceptibility loci ; NON-HODGKIN-LYMPHOMA ; RISK LOCI ; EPIDEMIOLOGIC RESEARCH ; CELL DEVELOPMENT
    Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 x 10(-15)) and HLA-B (rs2922994, P=2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
    Type of Publication: Journal article published
    PubMed ID: 25569183
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  • 9
    Abstract: Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82,P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51,P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
    Type of Publication: Journal article published
    PubMed ID: 27008888
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  • 10
    Keywords: PEPTIDE ; EXPRESSION ; TOOL ; RISK ; VARIANTS ; CLASS-I ; SNPs ; RESOURCE ; SET ; UNIVERSITY
    Abstract: Genome-wide association studies (GWASs) of follicular lymphoma (FL) have previously identified human leukocyte antigen (HLA) gene variants. To identify additional FL susceptibility loci, we conducted a large-scale two-stage GWAS in 4,523 case subjects and 13,344 control subjects of European ancestry. Five non-HLA loci were associated with FL risk: 11q23.3 (rs4938573, p = 5.79 x 10(-20)) near CXCR5; 11q24.3 (rs4937362, p = 6.76 x 10(-11)) near ETS1; 3q28 (rs6444305, p = 1.10 x 10(-10)) in LPP; 18q21.33 (rs17749561, p = 8.28 x 10(-10)) near BCL2; and 8q24.21 (rs13254990, p = 1.06 x 10(-8)) near PVT1. In an analysis of the HLA region, we identified four linked HLA-DRbeta1 multiallelic amino acids at positions 11, 13, 28, and 30 that were associated with FL risk (pomnibus = 4.20 x 10(-67) to 2.67 x 10(-70)). Additional independent signals included rs17203612 in HLA class II (odds ratio [ORper-allele] = 1.44; p = 4.59 x 10(-16)) and rs3130437 in HLA class I (ORper-allele = 1.23; p = 8.23 x 10(-9)). Our findings further expand the number of loci associated with FL and provide evidence that multiple common variants outside the HLA region make a significant contribution to FL risk.
    Type of Publication: Journal article published
    PubMed ID: 25279986
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