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  • 1
    ISSN: 1435-2451
    Keywords: Disinfectants ; Wound healing ; Desinfektionsmittel ; Wundbehandlung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Ein Biguanid haltiges Desinfiziens “GX” wurde auf seine Verwendbarkeit zur lokalen Wundbehandlung getestet und mit Betadine verglichen. Im Gegensatz zum Jodophor bleibt die Bactericidie von “GX” auch in Gegenwart von Proteinen erhalten. Die Gewebsverträglichkeit bactericider Lösungen von “GX” (0,1/0,2%) und Betadine (1:10) erwies sich sowohl bei Testung des Wachstums in vitro vorbehandelten Gewebes, als auch in Wundheilungsversuchen an Meerschweinchen (Behandlung während 10 Tagen) als sehr gut. Höhere Konzentrationen setzten die Gewebsverträglichkeit herab. Vor allem aufgrund der besseren bactericiden Wirkung in Gegenwart von Proteinen dürfte das Biguanidpräparat dem Jodophor bei therapeutischer Anwendung überlegen sein.
    Notes: Summary “GX”, a disinfectant containing biguanide, was tested with regard to topical wound treatment and compared with Betadine. During in vitro tissue-growth tests, as well as 10 days of wound-healing tests on guinea pigs, both disinfectants showed very good tissue tolerance, GX being superior to Betadine when used in bactericidal concentrations (0.1% or 0.2%). Whereas in aqueous solutions Betadine showed better bactericidal activity than GX, it became ineffective in the presence of proteins, while GX maintained its activity in the presence of 20 % defibrinated blood. This difference particularly stresses the potential therapeutic value of GX for topical wound disinfection.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    ISSN: 1600-051X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract. The influence of chlorhexidine rinsing on wound healing was studied using standardized, open mucosal-osseous wounds in the left side of the palate in Wistar rats. In five test groups, each containing 10 rats, rinsing was performed twice daily for 30 sec with 0.1, 0.2 and 0.5 % chlorhexidine solution, chlorhexidine solution vehicle, and Ringer solution. A sixth test group (control) was not rinsed at all. Seven days postoperatively, wound healing was evaluated clinically (size of the defect) and histomorphometrically (percent composition of mature connective tissue, immature connective tissue, granulation tissue, fibrin with granulocytic infiltrate). Clinically it was clear that wound healing was best in those animals that rinsed with Ringer solution, and worst in those that rinsed with 0.5 % chlorhexidine solution. Increasing concentration of chlorhexidine caused a delay in wound healing, which in the following cases resulted in significant differences: rinsing with Ringer solution and vehicle versus all concentrations of chlorhexidine, no rinsing versus 0.5 % chlorhexidine. Intensive rinsing with high concentrations of chlorhexidine may, after oral surgical operations, especially surgery in which bone is. exposed, result in delay and disturbance of wound healing in humans.
    Type of Medium: Electronic Resource
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  37. Jahrestagung der Deutschsprachigen Arbeitsgemeinschaft für Verbrennungsbehandlung (DAV 2019); 20190109-20190112; Schladming, Österreich; DOC46 /20190108/
    Publication Date: 2019-01-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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