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  • 1
    ISSN: 1432-2196
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Activation of T cell may be accomplished following the interaction of the TCR-CD3 complex with antigen and MHC products. In vitro this may be replaced by antibodies to the TcR or CD3 complex which mimic ligand binding. So called “alternative pathways” may also trigger activation. Activational state may be measured by lymphokine production, proliferative capacity or by expression of activation antigens. By these criteria a proportion of T cells isolated from rheumatoid joints appear to have undergone an in vivo activation. Phenotypic analysis of the synovial T cells has also established that there is an unusual distribution of Tγδ and Tαβ cells and T cell subsets in many rheumatoid patients. As T cells play a central role in immunoregulation, further exploitation of these observations using T cell clones and molecular techniques will extend our understanding of the disease process. In particular, further knowledge is required on the possible role of Tγδ cells in RA, the clonality of the T cells, the possible use of “alternative” activation pathways, and ultimately, the specificity of these T cells.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: We have analysed the effects of the lys 3a mutation on mRNA levels in the developing aleurone and starchy endosperm. The objective was to investigate whether the increase in non-hordein gene mRNA is a compensation for decreased hordein mRNA levels or if the increase is a result of a selective transcriptional or posttranscriptional regulation of specific genes. Our results show that protein Z and β-amylase which are downregulated by the lys 3a mutation are affected only in the starchy endosperm. In contrast, mRNA levels for the chymotrypsin inhibitors (CI-1, CI-2) are enhanced in the aleurone as well as in the starchy endosperm. The two isoform inhibitor genes of CI-1 (CI-1A, CI-1B) are differentially affected in the aleurone by the lys 3a mutation. The lys 3a gene enhances mRNA levels of two aleurone-specific genes. Together, these findings suggest that the lys 3a gene encodes or affects a regulatory factor which specifically modulates mRNA levels of several genes in different seed tissues.
    Type of Medium: Electronic Resource
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