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  • 1
    ISSN: 1432-2072
    Keywords: Amobarbital ; Avoidance Extinction ; Amobarbital-Avoidance Interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The present study was concerned with the effect of amobarbital on the extinction of unsignaled shuttlebox avoidance, and the effect exerted subsequently by a conditioned fear stimulus (CS+) on avoidance responding following the extinction of the avoidance response with amobarbital. Rats were given unsignaled shuttlebox avoidance training, then given separate Pavlovian fear conditioning, followed by avoidance extinction sessions under amobarbital with Pavlovian conditioning without drug continuing on alternate days. The CS+ was then presented during two post avoidance extinction tests sessions to determine the effect of the CS+ on the avoidance response extinguished under amobarbital. It was found that 20 mg/kg amobarbital facilitated the extinction of unsignaled shuttlebox avoidance, but failed to block the reaction (i.e., elicitation of avoidance response) to the CS+ in the same setting.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The major purpose of the present experiment was to assess the differential effectiveness of chlordiazepoxide on avoidance response acquisition and extinction. Two groups of rats, one as control and the other treated with chlordiazepoxide were compared on avoidance response acquisition. No significant differences were noted between the two groups, indicating that chlordiazepoxide was not effective in modifying the rate of avoidance response acquisition. The chlordiazepoxide group was then divided into two subgroups, one continued on chlordiazepoxide and the other deprived of chlordiazepoxide for the extinction training. The control group was also divided into two subgroups, one continued as control and the other treated with chlordiazepoxide for the extinction training. These divisions resulted in closely matched subgroups in the number of avoidance response acquisition, making intergroup comparisons of extinction performance possible. This intergroup comparison showed that chlordiazepoxide was effective in modifying the rate and degree of extinction. Less resistance to extinction was shown by the groups specifically treated with chlordiazepoxide during the extinction period, demonstrating that the effectiveness of chlordiazepoxide was confined mainly to the extinction process. These results were evaluated with the view that a conditioned avoidance response is mediated by fear, and an attempt was made to account for the effects of chlordiazepoxide on fear upon which the condition avoidance response is thought to depend.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-2072
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study examined the effects of different doses of amobarbital on avoidance learning. Six groups receiving 0, 5, 10, 20, 30, and 40 nig/kg amobarbital were trained on a hurdle-crossing avoidance task. Learning increased, and was optimum at 20–30 mg/kg and dropped sharply at 40 mg/kg. Similar results were obtained for intertrial hurdle-crossing, indicating a direct relationship between avoidance response and intertrial hurdle-crossing.
    Type of Medium: Electronic Resource
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