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  • 1
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    New York : McGraw-Hill
    Call number: WL100:22(5) ; A240:4 ; A270:5
    Keywords: Central Nervous System / physiology ; Mental Processes / physiology ; Nervous System Diseases ; Neuropsychology
    Description / Table of Contents: Machine generated contents note: PART I: Overall Perspective (Kandel, Hudspeth)1. The Brain and Behavior (Kandel, Hudspeth)2. Nerve Cells, Neural Circuitry, and Behavior (Kandel, Barres, Hudspeth)3. Genes and Behavior (Bargmann, Gilliam) PART II: Cell and Molecular Biology of the Neuron (Siegelbaum, Hudspeth)4. The Cells of the Nervous System (Schwartz, Barres, Goldman)5. Ion Channels (Siegelbaum, Koester)6. Membrane Potential and the Passive Electrical Properties of the Neuron (Siegelbaum, Koester)7. Propagated Signaling: The Action Potential (Siegelbaum, Koester) PART III: Overview: Synaptic Transmission (Siegelbaum, Hudspeth)8. Overview of Synaptic Transmission (Siegelbaum, Kandel)9Signaling at the Nerve Muscle Synapse: Directly Gated Transmission (Siegelbaum, Kandel)10. Synaptic Integration in the Central Nervous System (Siegelbaum, Kandel, Yuste)11. Modulation of Synaptic Transmission: Second Messengers (Clapham, Siegelbaum, Schwartz)12. Transmitter Release (Siegelbaum, Kandel, Sudhof)13. Neurotransmitters (Schwartz, Javitch)14. Diseases of Nerve and the Motor Unit (Brown, Cannon, Rowland) PART IV: The Neural Basis of Cognition (Hudspeth, Kandel)15. The Organization of the Central Nervous System (Amaral, Strick)16. The Functional Organization of Perception and Movement (Amaral)17. From Nerve Cells to Cognition: The Internal Representations for Space and Action (Kandel)18. The Organization of Cognition (Olson, Colby)19. Cognitive Functions of the Premotor System (Rizzolatti, Strick)20. Functional Imaging of Cognition (Small, Heeger) PART V: Perception (Hudspeth)21. Sensory Coding (Gardner, Johnson)22. The Somatosensory System: Receptors and Central Pathways (Gardner, Johnson)23. Touch (Gardner, Johnson)24. Pain (Basbaum, Jessell)25. The Constructive Nature of Visual Processing (Gilbert)26. Low-Level Visual Processing: The Retina (Meister, Tessier-Lavigne)27. Intermediate-Level Visual Processing: Visual Primitives (Gilbert)28. High-Level Visual Processing
    Abstract: "The field's definitive work from a Nobel Prize-winning author 900 full-color illustrations Principles of Neural Science, 5e describes our current understanding of how the nerves, brain, and mind function. From molecules to anatomic structures and systems to cognitive function, this comprehensive reference covers all aspects of neuroscience. Widely regarded as the field's cornerstone reference, the fifth edition is highlighted by more than 900 full-color illustrations. The fifth edition has been completely updated to reflect the tremendous amount of new research and development in neuroscience in the last decade. Lead author Eric Kandel was awarded the Nobel Prize in Physiology or Medicine in 2000"--Provided by publisher
    Pages: xlix, 1709 p.
    Edition: 5th ed.
    ISBN: 9780071390118
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    WL100:22(5) available
    A240:4 departmental collection or stack – please contact the library
    A270:5 departmental collection or stack – please contact the library
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  • 2
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have identified the processes of mechanoreceptor sensory neurons by intracellular injection of horseradish peroxidase in order to study the structure of synapses which exhibit profound, behaviourally-relevant plasticity. These synapses are located at small, varicose expansions along or at the end of the fine, microtubule-containing neurites, and they are crowded with vesicles some of which are associated with the varicosity membrane at regions of membrane specialization morphologically equivalent to active zones described in other species. These active zones occur between pre- and postsynaptic processes at two varieties of apposition: a conventional flat one, and a more elaborate indented one. At indented appositions, the presynaptic varicosity is invaginated by a thin (less than 0.25 μm diameter) spine of variable length. The active zones of indented synapses have approximately twice the vesicle frequency of flat synapses, suggesting that indented synapses are more effective. Sensory neuron terminals are relatively uniform in their structure, having similar concentrations of vesicles and numbers of active zones, and the majority of the processes postsynaptic to them are less than 0.5 μm in diameter. These regularities, and the presence of two strikingly-different types of synaptic apposition, flat and indented, should facilitate structural comparisons of neurons from naive and behaviourally-modified animals. The possible dynamic interconversion of indented and flat appositions at the synaptic terminals of sensory neurons and its behavioural relevance are discussed.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: As part of our continuing studies into the biochemical basis of long-term changes in neuronal function in Aplysia, we have developed a simple method for obtaining amino acid sequence information from proteins isolated on two-dimensional gels. Proteins isolated on preparative two-dimensional gels are digested in situ with Staphylococcus, aureus V8 protease, and the resulting peptides electrophoresed, transferred to a polyvinylidene difluoride membrane, and sequenced in a gas-phase sequencer. The method is simple and should be applicable to a variety of other systems where the development of a two-dimensional gel database is underway.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] An inhibitor of soluble guanylyl cyclase LY83583 (50% inhibitory concentration IC50=:2 uM)12, completely blocked the induction of LTP at a concentration of 5 jiM (Fig. la), and occasionally blocked it at a concentration of 0.5 uM (two of six experiments). The effects of the inhibitor are relatively ...
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To identify new immediate-early genes whose expression is dependent on neuronal activity, we differentially screened -30,000 primary clones from our hippocampal complementary DNA library (see Fig. 1 legend) using two cDNA probes derived from mRNA isolated from the cortex of untreated animals (- ...
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] 5-HT and FMRFamide produce opposing modulatory changes in the electrical excitability of the sensory neuron and in transmitter release from the sensory neuron presynaptic terminals14'16. By acting through cAMP-dependent phosphorylation, 5-HT produces prolonged all-or-none closure of the S-K+ ...
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] To investigate biochemical mechanisms relating short- and long-term facilitation in the connections between the sensory and motor neurons in Aplysia, we first applied a single 2-min pulse of 5-HT (40 (Jim) to sensory neurons that had been labelled with 32P to isotopic equilibrium. A single pulse of ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 558-560 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] High-frequency stimulation of the Schaffer collateral/com-missural fibre pathway to the CA1 pyramidal cells leads to three sequential and well-characterized changes in synaptic effectiveness: (1) post-tetanic potentiation lasting 2 min; (2) decremental facilitation lasting 30-40 min; and (3) ...
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  • 9
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 322 (1986), S. 419-422 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A single learning event initiates several memory processes with different time courses of retention. While short term memory involves covalent modification of pre-existing proteins, the finding that long-term memory requires the expression, during learing, of additional genes, makes it possible to ...
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  • 10
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Type of Medium: Electronic Resource
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