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Wie hoch liegen die Personalkosten für die Durchführung einer OSCE mit Simulationspatienten?Eine Kostenaufstellung nach betriebswirtschaftlichen Gesichtspunkten (2010)

Rau, T ; Brettschneider, J ; Weber, YG ; [et al.]

German Medical Science GMS Publishing House; Düsseldorf

In: Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA); 20100923-20100925; Bochum; DOC10gma146 /20100805/

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Publication Date: 2010-08-06

Keywords: ddc: 610

Language: German

Type: conferenceObject

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GERMAN MEDICAL SCIENCE

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Inflammatory dysregulation of blood monocytes in Parkinson's disease patients

Grozdanov, V ; Bliederhaeuser, C. ; Ruf, W.P. ; [et al.]

Acta Neuropathologica 128 (5), 651-663

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Keywords: brain ; CELLS ; DENDRITIC CELLS ; ASSOCIATION ; BONE-MARROW ; LYMPHOCYTES ; MOUSE MODEL ; CENTRAL-NERVOUS-SYSTEM ; microglia ; AMYOTROPHIC-LATERAL-SCLEROSIS ; inflammation ; FAS ; BLOOD MONOCYTES ; Parkinson's disease ; CCL2 ; FAS/FASLG

Abstract: Despite extensive effort on studying inflammatory processes in the CNS of Parkinson's disease (PD) patients, implications of peripheral monocytes are still poorly understood. Here, we set out to obtain a comprehensive picture of circulating myeloid cells in PD patients. We applied a human primary monocyte culture system and flow cytometry-based techniques to determine the state of monocytes from PD patients during disease. We found that the classical monocytes are enriched in the blood of PD patients along with an increase in the monocyte-recruiting chemoattractant protein CCL2. Moreover, we found that monocytes from PD patients display a pathological hyperactivity in response to LPS stimulation that correlates with disease severity. Inflammatory pre-conditioning was also reflected on the transcriptome in PD monocytes using next-generation sequencing. Further, we identified the CD95/CD95L as a key regulator for the PD-associated alteration of circulating monocytes. Pharmacological neutralization of CD95L reverses the dysregulation of monocytic subpopulations in favor of non-classical monocytes. Our results suggest that PD monocytes are in an inflammatory predisposition responding with hyperactivation to a "second hit". These results provide the first direct evidence that circulating human peripheral blood monocytes are altered in terms of their function and composition in PD patients. This study provides insights into monocyte biology in PD and establishes a basis for future studies on peripheral inflammation

DOI: 10.1007/s00401-014-1345-4

Type of Publication: Journal article published

PubMed ID: 25284487

Deep Link: http://www.dkfz.de/cgi-bin/sel?http://www.dkfz.de/PublicationManager/Show/ShowJournal.aspx%3fpublishedId=55595

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Elektromyographische Untersuchung nach minimalinvasiver Frakturversorgung am proximalen Humerus über einen kleinen anterolateralen Deltasplit (2009)

Röderer, G ; Hansen, P ; Sperfeld, AD ; [et al.]

German Medical Science GMS Publishing House; Düsseldorf

In: Deutscher Kongress für Orthopädie und Unfallchirurgie; 73. Jahrestagung der Deutschen Gesellschaft für Unfallchirurgie, 95. Tagung der Deutschen Gesellschaft für Orthopädie und Orthopädische Chirurgie, 50. Tagung des Berufsverbandes der Fachärzte für Orthopädie; 20091021-20091024; Berlin; DOCWI44-1286 /20091015/

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Publication Date: 2009-10-16

Keywords: ddc: 610

Language: German

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Cryoglobulinemia: A complication of infectious disease (1994)

Witzke, O. ; Kassubek, J. ; Bonmann, E. ; [et al.]

Springer

Journal of molecular medicine 72 (1994), S. 1048-1050

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ISSN: 1432-1440

Keywords: Cryoglobulinemia ; Cytomegalovirus ; Autoimmune disease

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Abstract We report on a 23-year-old male patient with general weakness, subfebrile temperatures, and arthralgia. The first symptoms were observed some months after a severe cytomegalovirus mononucleosis-gastroenteritis. High titers of cryoglobulins suggested an autoimmunological process. This case is interesting because of the association between cytomegalovirus infection and cryoglobulinemia. In conclusion, the differential diagnosis of autoimmune disease should be considered in the course of viral infections.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00577753

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