Blackwell Publishing Journal Backfiles 1879-2005
Aim: Multi-center's clinical study, using allogeneic CDS are proceeded in 30 hospitals as the Millennium Project of the Ministry of Health, Labor and Welfare. The clinical trial in our hospital was designed to evaluate the efficacy of CDS for the treatment of refractory skin ulcers. Methods: The application of CDS on the debrided wound was repeated at an interval of 3 to 5 days. The evaluation was performed according to the protocol, especially focused on granulation tissue formation, wound size reduction, and epithelialization. Results: The clinical trials were conducted in 6 cases, including 5 cases with various complications, i.e., diabetes (2 cases), collagen diseases (1 case), renal failure (1 case), and skin defect after resection of tumor (1 case). According to the comprehensive judgement, 5 cases were evaluated as achieving excellent, and 1 case was evaluated as achieving good. Conclusion: The successful application of CDS is dependent on the control of wound conditions free from infection. Appropriate debridment was necessary prior to application of CDS.
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