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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  83. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie; 20120516-20120520; Mainz; DOC12hnod044 /20120404/
    Publication Date: 2012-04-05
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    HNO 46 (1998), S. 692-694 
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Cochlear-Implant ; Tullio-Phänomen ; Postoperativer Schwindel ; Key words Cochlear implantation ; Tullio phenomenon ; Postoperative vertigo
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary The Tullio phenomenon is defined as an acoustically inducible vestibular disorder that was first described in 1929. In an animal experiment Tullio provoked acoustic oscillations at the labyrinth followed by signs of imbalance. In the literature this phenomenon can be found in healthy but sensitive persons as well as in patients with Meniere’s disease and patients with lesions between the stapes, footplate and the membranous labyrinth caused by fractures, stapes dislocations, labyrinthitis or perilymphatic fistulas. In this case report a patient complained about vertigo after cochlear implantation provoked by acoustical stimulation at a sound pressure level above 90 dB independent of the cochlear implant (CI). During tympanoscopy we found scar tissue surrounding the ossicles after CI. After disconnecting the ossicular chain no vertigo or nystagmus could be provoked. After CI regular ENT examinations and appropriate explorations of postoperative complaints are necessary. Vertigo especially requires very careful diagnostic procedures.
    Notes: Zusammenfassung Das sog. Tullio-Phänomen wird als akustisch auslösbare Gleichgewichtsstörung definiert. Sein Erstbeschreiber Tullio (1929) konnte tierexperiementell Schwingungen im häutigen Labyrinth nach akustischer Provokation nachweisen, die zu subjektiver Schwindelsymptomatik führen. Diverse Autoren beschreiben dieses Phänomen sowohl als physiologische Reaktion und als zusätzliches Symptom bei M. Menière. Verwachsungen zwischen Stapesfußplatte und häutigem Labyrinth nach Felsenbeinfrakturen, bei Zustand nach Labyrinthitis, Stapesfehllage oder bei Fisteln der Endolymophschläuche werden in ursächlichem Zusammenhang gebracht [3, 4, 7, 13]. In dem vorliegenden Fall beklagte der Patient einen akustisch auslösbaren Schwindel, der auch bei ausgeschaltetem „cochlear implant” (CI) bei Schallpegeln über 90 dB auftrat. Nach Amboßentfernung war subjektiv kein Schwindel mehr vorhanden, der Nystagmus nicht mehr nachweisbar. Nach CI-Operationen ist eine regelmäßige Otoskopie und eine adäquate Exploration möglicher postoperativer Komplikationen erforderlich. Insbesondere postoperative Schwindelbeschwerden erfordern eine subtile Diagnostik, um auch seltene, z.B. mittelohrbedingte Ursachen aufzuspüren.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0458
    Keywords: Schlüsselwörter Otobasisfraktur ; Meningitis ; Rhinoliquorrhö ; Key words Temporal bone fracture ; Rhinoliquorrhea ; Meningitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report our experience in managing a temporal bone fracture after head trauma that had no apparent clinical signs. Recurrent CSF rhinorrhea and meningitis lead to extensive diagnostic procedures. Operative exploration of the temporal bone demonstrated a fracture line along the horizontal part of the carotid artery. The location of the fracture did not cause such typical symptoms as hearing impairment, facial paralysis, vertigo or tinnitus. Only CSF liquorrhea through the Eustachian tube indicated a fracture at the lateral skull base.
    Notes: Zusammenfassung In dieser Kasuistik wird eine Otobasisfraktur nach Schädel-Hirn-Trauma (SHT) beschrieben, die zunächst klinisch stumm verlief. Erst eine rezidivierend aufgetretene Rhinoliquorrhö mit mehrfachen Meningitiden führte zu einer erweiterten Diagnostik. Die operative Revision der Otobasis über einen transtemporalen Zugang zeigte eine Felsenbeinlängsfraktur mit Knochenlücke im Bereich des horizontalen Karotiskanals. Diese hatte jedoch nicht zu den erwarteten Symptomen, wie Hörminderung, Fazialisparese, Vertigo oder Tinnitus geführt, sondern erst der Liquorabflußüber die Tuba eustachii bedingte die weitere Diagnostik.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1434-4726
    Keywords: epidermodysplasia verruciformis ; Human papilloma virus ; Head and neck ; Diagnosis ; Treatment In situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Data from a young adult man with epidermodysplasia verruciformis (EV) and multiple metachronous spinaliomas in the head and neck region are presented. Diagnosis of this rare, human papilloma virus (HPV)-associated disease was based on: (1) Typical skin lesions, including viral warts, verruca plana-type lesions and pityriasis versicilor; (2) typical histological features, including ‘foamy giant keratinocytes”; (3) evidence of HPV 5, 8 and 20 in pityriasis versicilor-like lesions; (4) a cellular immunodeficiency due to a relative T-helper-cell deficit. No specific treatment of EV is known, so that therapy concentrates on early removal of spinaliomas and treatment of intercurrent infections. Since EV patients have numerous benign skin lesions and frequently develop metastatic and non-metastatic carcinomas, molecular changes of HPV during carcinogenesis can be studied.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1434-4726
    Keywords: In situ hybridization ; Oligonucleotide probe ; Cochlear neurotransmission ; Gamma-aminobutyric acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The inhibitory neurotransmitter gamma-arninobutyric acid (GABA) is most likely involved in the efferent cochlear neurotransmission. In situ hybridization (ISH) results in specific annealing of a labelled nucleic acid probe to complementary sequences in fixed tissue and allows subsequent visualization of the location of the probe. We used the ISH technique to localize messenger ribonucleic acid (mRNA) sequences of the alpha-1 subunit of the GABAA receptor with an S-35 labelled oligonucleotide probe. Experiments were performed in rat and guinea pig brain sections and surface tissue preparations of the guinea pig cochlea. Positive signals were obtained for the alpha-1 probe in cortical and hippocampal regions of the rat brain and had weaker expression in the guinea pig brain. Alpha-1 subunit mRNA was localized in Purkinje cells and in stellate and basket cells of the stratum moleculare in the rat and guinea pig cerebellum. In surface tissue preparations of the guinea pig cochlea mRNA sequences of the alpha-1 subunit were detectable with high signal expression. Positive signals were seen on both sides of the tunnel of Corti, predominantly in the region of the outer hair cells. The results indicate expression of GABAA-receptor mRNA in cochlear tissue, supporting the importance of GABAA receptors in cochlear neurotransmission.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1434-4726
    Keywords: Isolated outer hair cells ; Glutaraldehyde cell fixation ; Cuticular plate ; Cell motility ; Guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Motile properties of outer hair cells (OHCs) may contribute to sharp tuning and amplification in the mammalian cochlea. Shape changes of isolated OHCs in response to various physical and chemical influences have been investigated intensively. However, determinations of shape may have been influenced by unanticipated effects of preparation and preservation of the OHCs investigated. Thus, in a first step, lengths of freshly isolated OHCs from the guinea pig cochlea were determined using a video-enhancing magnification system. The cuticular plate/cell axis angle (CP/CA angle) was then measured in native cells and under the influence of potassium chloride and potassium gluconate incubation. To show the influence of glutaraldehyde (GA) fixation on the isolated OHCs, fixative dependent changes on cell length and CP/CA angle were recorded in native and preincubated OHCs. In these experiments, the cell length of vital isolated OHCs was between 41.5 μm, in the basal turn, and 103.7 μm, in the apical turn. The average CP/CA angle was 106° ± 4.2° (n = 324 cells, turns 1–4) with no statistically significant differences for the four turns. Under the influence of potassium chloride, cell length was reduced by 8.1%. Potassium gluconate incubation led to a shortening of cell length, followed by a 5.3% increase after 5 min. The CP/CA angle under potassium chloride was decreased (97.0°) and was then increased under the influence of potassium gluconate (110.7°) as a result of cuticular plate tilting. Cell shrinkage after fixation depended on the fixative's osmolarity and on the GA concentration. Increased GA levels amplified cell shrinkage from 34% for hypo-osmolar solutions to 15% in iso-osmolar and 29% in hyperosmolar solutions. The CP/CA angle of native and incubated OHCs was not different from those fixed with GA. The present data provide a rational basis for isolated OHC shape parameters. Moreover, functionally induced changes can be better interpreted when OHCs are influenced by fixatives, as shown in the GA experiments.
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  • 7
    ISSN: 1434-4726
    Keywords: Key words Cochlear implant ; Management of ; complications ; Children ; Postoperative care ; Infection ; Device failure ; Reimplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a retrospective analysis we evaluated the intra- and postoperative complications in children who underwent cochlear implantation between 1984 and 1993 at the Medizinische Hochschule Hannover. The data and records of 366 children were collected and analyzed. Relevant parameters were major complications such as significant infection, intraoperative bleeding, facial nerve injury, implant loss and device failure, as well as lesser complications, including delayed wound healing, chronic pain and vertigo. Late complications such as cholesteatoma or electrode dislocations were also registered. Cases of acute otitis media were managed with conservative treatment. Data presented indicate that cochlear implant surgery in children is a reliable and safe procedure with a low percentage of severe complications. Problems related to ear surgery can occur and should be manageable with standard procedures. Careful operative techniques and sufficient personal experience can help avoid severe postoperative problems.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1434-4726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Plant systematics and evolution 29 (1879), S. 372-377 
    ISSN: 1615-6110
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Plant systematics and evolution 29 (1879), S. 411-411 
    ISSN: 1615-6110
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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