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  • 1
    Keywords: RECEPTOR ; CELLS ; EXPRESSION ; IN-VITRO ; tumor ; Germany ; THERAPY ; VITRO ; DISEASE ; DISEASES ; MICE ; ACTIVATION ; MECHANISM ; REDUCTION ; ANTIGEN ; DENDRITIC CELLS ; SKIN ; T cell activation ; T cells ; T-CELLS ; treatment ; MIGRATION ; RECRUITMENT ; ANTIGEN-PRESENTING CELLS ; C3H/HEJ MICE ; FOLLICLE ; SUBSET ; RE ; HAIR FOLLICLE ; LYMPHOID ORGANS ; REGULATORY T-CELLS ; DELAYED-TYPE HYPERSENSITIVITY ; RECOVERY ; HAIR LOSS ; lymph node ; LYMPH-NODE ; RELEVANCE ; AA ; autoimmune disease ; PROGRESS ; ACID DIBUTYLESTER SADBE ; ACTIVATED T-CELLS ; ATOPIC-DERMATITIS ; SKIN-ASSOCIATED CHEMOKINE
    Abstract: Long-lasting allergen treatment is the most efficient therapy in alopecia areata (AA). The underlying mechanism is unknown. We here asked whether treatment with a contact sensitizer influences leukocyte migration such that dendritic cell (DC) migration or the recruitment of activated T-cells towards the skin become hampered. Allergen treatment of AA mice was not accompanied by a decrease in skin- infiltrating leukocytes or draining lymph node cells (LNC). However, the distribution of leukocyte subsets was changed with a dominance of monocytes in the skin and a reduced percentage of DCs in draining nodes. Chemokine and chemokine receptor expression in skin and draining nodes was strikingly increased and LNC from untreated and allergen-treated AA mice showed high migratory activity in vitro and readily homed in draining nodes and skin after intravenous injection. However, FITC labelling of the skin and subcutaneous transfer of dye-labelled DC revealed that allergen treatment created a chemokine milieu severely hampering DC migration from the skin towards the draining node. An allergic eczema. Induced reduction in DC migration and antigen transfer could well contribute to insufficient T-cell activation and the recovery of hair follicle in AA and possibly be of relevance for other skin- related autoimmune diseases
    Type of Publication: Journal article published
    PubMed ID: 16675965
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  • 2
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Eine neue Methode zum raschen, oxydativen Aufschluß von hochaktiven Graphittabletten, Aktivkohle und beschichteten Kernbrennstoffpartikeln (“coated particles”) in Sauerstoff bei etwa 1000°C wird beschrieben. Der Aufschluß wird in einer einfachen, fernbedienbaren Quarz-Anordnung in einer Bleizelle durchgeführt. Die Probenasche wird für Strontiumbestimmungen in HF/HCl oder anderen Säuregemischen gelöst; die Gesamtausbeute hierfür liegt bei mindestens 99%.
    Notes: Abstract A new method for rapid oxidizing digestion of highly radioactive graphite pellets, charcoal and coated particles in oxygen at about 1000° C is described. Digestion is carried out in a simple remote handling quartz-apparatus in a lead cell. The sample ash is dissolved for strontium determination in HF/HCl or other acid mixtures. The over-all yield was found to be at least 99%.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0138-4988
    Keywords: Life Sciences ; Life Sciences (general)
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: The aim of this work was to prove if a Bordetella bronchiseptica living vaccine is able to induce humoral and local antibodies in pigs. The living vaccine was compared with a killed Bordetella bronchiseptica adjuvans vaccine. The results show that piglets of sows vaccinated parenterally with living vaccine and killed adjuvans vaccine develop a stronger humoral immune reaction than piglets vaccinated locally with living vaccine. Sows immunized parenterally with living vaccine permint their piglets in the first three weeks colostral antibodies like sows immunized with killed adjuvans vaccine. The living vaccine induces especially local antibodies.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1437-160X
    Keywords: Anti-cardiolipin antibodies ; IgG ; IgM Systemic lupus erythematosus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a multicentre study anticardiolipin antibodies of the IgG and IgM isotypes were measured by a solid phase enzyme immunoassay in 368 patients with systemic lupus erythematosus (SLE) who were not selected on the basis of features of antiphospholipid syndrome. Clinical and laboratory associations of increased levels of anticardiolipin antibodies were evaluated. IgG and IgM antibodies to cardiolipin were documented in 224 (60.9%) and 128 (34.8%) patients, respectively. Regarding the symptoms of antiphospholipid syndrome, elevated amounts of anticardiolipin IgG were significantly associated with spontaneous abortion (P〈0.001), thrombocytopenia (P〈0.01), livedo reticularis (P〈0.01) and a positive direct Coombs test (P〈0.05), but not with thrombosis or central nervous system diseases such as epilepsy and psychosis. IgM antibodies to cardiolipin were associated with a positive direct Coombs test (P〈0.01), but with no other symptom of antiphospholipid syndrome. The predictive values of anticardiolipin antibody determinations in unselected SLE patients were poor for all features of antiphospholipid syndrome because of high proportions of false-positive and false-negative results. As for other manifestations of SLE, positive correlations between raised antibodies to double-stranded DNA and the occurrence of anticardiolipin antibodies of the IgG isotype were observed, and anticardiolipin IgM was negatively associated with nephritis.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1437-160X
    Keywords: Immunoglobulin allotypes ; Systemic lupus erythematosus ; Genetics ; Gm ; Km ; HLA-antigens ; Autoantibodies ; Clinical symptoms
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Immunoglobulin heavy chain (G1m, G2m, G3m, A2m) and kappa light chain (Km) allotype and phenotype frequencies of 323 central European Caucasian patients with systemic lupus erythematosus (SLE) were examined and correlated with various genetic, serologic and clinical markers of SLE. No significant associations were found between immunoglobulin allotypes or phenotypes and all 20 parameters tested (nephritis, vasculitis, arthralgias, photosensitivity, discoid lesions, central nervous system disease, Raynaud's phenomenon, sex, anti-Ro, anti-La, anti-nRNP, HLA-DR1-DR7, HLA phenotypes B8-DR3, B7-DR2). It could therefore be assumed that Gm, A2m and Km allotypes were not associated with HLA-antigens and had no influence on the serologic and clinical expression of SLE.
    Type of Medium: Electronic Resource
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