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  • 1
    Abstract: Protection of endothelial integrity has been recognized as a frontline approach to alleviating sepsis progression, yet no effective agent for preserving endothelial integrity is available. Using an unusual anti-angiopoietin 2 (ANG2) antibody, ABTAA (ANG2-binding and TIE2-activating antibody), we show that activation of the endothelial receptor TIE2 protects the vasculature from septic damage and provides survival benefit in three sepsis mouse models. Upon binding to ANG2, ABTAA triggers clustering of ANG2, assembling an ABTAA/ANG2 complex that can subsequently bind and activate TIE2. Compared with a conventional ANG2-blocking antibody, ABTAA was highly effective in augmenting survival from sepsis by strengthening the endothelial glycocalyx, reducing cytokine storms, vascular leakage, and rarefaction, and mitigating organ damage. Together, our data advance the role of TIE2 activation in ameliorating sepsis progression and open a potential therapeutic avenue for sepsis to address the lack of sepsis-specific treatment.
    Type of Publication: Journal article published
    PubMed ID: 27099174
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  • 2
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Biodiversity and conservation 2 (1993), S. 191-214 
    ISSN: 1572-9710
    Keywords: arthropods ; extinction ; inventory and monitoring ; survey
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Western culture views insects and arachnids as pests and vermin that need to be controlled. They usually are not considered as something to be preserved. Accordingly, arthropods and other small organisms have not been taken seriously for conservation by policy makers and the conservation community at large. Having existed for more than 400 million years and after surviving the Permian and Cretaceous mass extinctions, arthropods have been the most successful of all living things and along with other invertebrates constitute more than three-quarters of today's global biodiversity. Arthropods are major components of diverse ecosystems and are the major players in functioning of ecosystem processes. Nevertheless, arthropods, which are the least known and, along with other plants and animals, are relentlessly vanishing before our eyes. Thus, aside from anthropocentric perception and societal prejudice, arthropods certainly are not pests in an ecological or evolutionary context and have an inherent biological right to exist in an evolutionary context, with ecological and instrumental values. They must be preserved because of their inherent values but also because we need them for human survival. Thus, arthropods must become an important and necessary part of the conservation strategy at all levels of environmental organization, from populations and species to ecosystems and landscapes. Insect conservation aims at saving both endangered species and ecosystem processes with a multitude of approaches targeted at different scales. Conservation efforts for arthropods are daunting because all the odds are against them: whereas species diversity, population size and biomass are so large, taxonomy and faunal information are inadequate; whereas the need for taxonomic and biodiversity information increases greatly, the shortage of taxonomic expertise worsens. Basic issues of biodiversity and the loss of species are reviewed. The goals and strategies for insect conservation are discussed with a focus on inventory and monitoring. Taxonomic and environmental surveys are compared, and the needs for biodiversity monitoring are discussed as ecological monitoring process based on inventory data. This monitoring focuses on the health of nested biodiversity (composition, structure and process) and the state of species, differing from other contemporary monitoring efforts.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Biodiversity and conservation 2 (1993), S. 189-190 
    ISSN: 1572-9710
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1573-5117
    Keywords: aquatic drift ; black flies ; sibling species ; periodicity ; running water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Larval (5th-final instar) drift patterns of five species of black flies (Prosimulium mixtum, Stegopterna mutata, Simulium tuberosum FG, S. vittatum IIIL-1, and S. vittatum IS-7) were analyzed. The diel drift patterns were not species-specific, but consistently exhibited a marked increase after sunset, preceded by a period of minimal drift. The drift minimum generally occurred during or shortly after the period of maximum water temperature. Larvae showed significantly more nocturnal than diurnal drift. Pupal drift was attributed to accidental detachment from the substrate. Adult drift was over 90% diurnal and usually composed primarily of teneral individuals. Upstream larval movements of the S. vittatum and S. tuberosum complexes were each less than 6.5% of the total upstream and downstream larval movements. The proportion of parasitized larvae of the S. vittatum and S. tuberosum complexes was generally higher in the benthos than in the drift. Based in part on data included in a thesis submitted by the senior author to The Pennsylvania State University in partial fulfillment of the requirements for the Ph. D. degree.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1939
    Keywords: Coexistence ; Competition ; Niche breadth ; Niche overlap ; Feather mites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Two species of feather mites, Alloptes (A.) sp. and Laronyssus martini, coexisted on the flight feathers of kittiwakes, while Alloptes (C.) sp. occurred alone on murres. All three species were found mostly on the ventral surface of mid-wing regions. On individual feathers, the mites were attached to the distal sides of barbs on the trailing vanes. The two species coexisted on kittiwakes but occupied different portions of feathers. The results suggest that the two species compete for the attachment site on the feather and Alloptes (A.) sp. is excluded by L. martini from the preferred microhabitat.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2018-02-28
    Description: Biochemistry DOI: 10.1021/acs.biochem.8b00053
    Print ISSN: 0006-2960
    Electronic ISSN: 1520-4995
    Topics: Biology , Chemistry and Pharmacology
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