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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Social Science & Medicine 28 (1989), S. 885 
    ISSN: 0277-9536
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Social Science & Medicine 25 (1987), S. 905-910 
    ISSN: 0277-9536
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 48 (1997), S. 157-165 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Zellzyklus ; Checkpoint ; Cycline ; Tumorsuppressorgene ; Apoptose ; Key words Cell cycle ; Checkpoint ; Cyclins ; Tumour-suppressor genes ; Apoptosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary During the past years the elucidation of cell cycle regulation has revolutionized our understanding of cancer development. Many new genes have been identified which promote genetic instability when mutated. They encode cyclins, inhibitors of cyclin-dependent kinases (CDKs) or other cell cycle regulators. The regulation of the CDK activities in different phases of the cell cycle controls the correct process of DNA synthesis and replication. Complex signal transduction systems, so-called checkpoints, regulate growth arrest, DNA repair and programmed cell death (apoptosis) and thereby prevent the formation of tumour cells. An overview is presented on the molecular mechanisms of cell cycle control and their significance for genetic stability. The functions of proto-oncogenes (e.g., c-myc) and tumour-suppressor genes (e.g., p53) in this context is described. In particular, recent advances in the understanding of skin carcinogenesis, the role of UV radiation and cancer therapy are discussed.
    Notes: Zusammenfassung Die Erfolge in der Aufklärung der Regulation des Zellzyklus haben während der letzten Jahre das Verständnis der Krebsentstehung revolutioniert. Zahlreiche neue Gene wurden entdeckt, deren Mutationen die genetische Instabilität fördern.Sie kodieren für Cycline, Inhibitoren von Cyclin-abhängigen Kinasen (CDKs) bzw. andere Zellzyklusregulatoren. Die Regulation der CDK-Aktivitäten in den verschiedenen Zellzyklusphasen steuert den korrekten Ablauf von DNS-Synthese und Replikation. Komplexe Signaltransduktionssysteme, sog. „Checkpoints”, regulieren Wachstumsblock, DNS-Reparatur und programmierten Zelltod (Apoptose) und tragen somit wesentlich dazu bei, die Entstehung von Tumorzellen zu verhindern. Es soll ein aktueller Überblick über die molekularen Mechanismen der Zellzykluskontrolle und ihre Bedeutung für genetische Stabilität gegeben werden. Die Funktionen von Proto-Onkogenen (z.B. c-myc) und Tumorsuppressorgenen (z.B. p53) in diesem Zusammenhang wird dargestellt. Insbesondere werden neue Aspekte der Hautkarzinogenese, der Rolle der UV-Strahlung und der Krebstherapie diskutiert.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Der Hautarzt 48 (1997), S. 253-257 
    ISSN: 1432-1173
    Keywords: Schlüsselwörter Juvenile hyaline Fibromatose ; Chromosomenanalyse ; Elektronenmikroskopie ; Key words Juvenile hyaline fibromatosis ; Chromosome-analysis ; Electronmicroscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Juvenile hyaline fibromatosis is a rare autosomal recessive connective tissue disease first described in 1873 by Murray. Major diagnostic criteria are multiple cutaneous tumors and gingival hypertrophy; minor criteria include contractures, osteolytic lesions and a positive family history. After a normal perinatal period at the age of 6 months our 24 year old patient developed gingival hypertrophy. During the first months of life several skin coloured nodules had been noticed on the neck and in the perianal area. At the age of 15 months, these nodules began to appear more rapidly, both spontaneously and posttraumatically. The patient showed normal development, but the lesions progressed. By the age of 15 years, the patient had extensive deformities and was unable to walk and move by himself. Both his sisters and the unrelated parents had no lesions. Essential for the diagnosis are the clinical picture and the histology. Electron microscopy is helpful to support the diagnosis. Defective connective tissue proteins such as chondroitin, collagen and mucopolysaccharides are probably the pathological defect. A therapy is so far unknown.
    Notes: Zusammenfassung Die juvenile hyaline Fibromatose ist eine sehr seltene erstmals 1873 von Murray beschriebene Bindegewebserkrankung mit autosomal rezessivem Erbgang. Diagnostische Hauptkriterien sind das Auftreten von multiplen kutanen Tumoren und Gingivahypertrophie, Nebenkriterien stellen die Entwicklung von Gelenkkontrakturen, osteolytischen Läsionen und das familiäre Vorkommen dar. Bei unserem 24jährigen Patienten zeigte sich nach unauffälliger Geburt und Neugeborenenperiode im Alter von 6 Monaten im Zusammenhang mit der Dentition eine Gingivahypertrophie. In den ersten Lebensmonaten fielen kleine hautfarbene Knötchen im Nacken sowie perianal auf, die nachfolgend ab dem 15. Lebensmonat verstärkt sowohl spontan, aber vornehmlich posttraumatisch, auftraten. Im weiteren Verlauf zeigte sich bei normaler geistiger Entwicklung eine deutliche Progredienz der Hautveränderungen mit nachfolgenden multiplen schwersten Deformationen der Extremitäten sowie Gelenksteifigkeit und Bewegungseinschränkungen, so daß ab dem 15. Lebensjahr eine selbständige Fortbewegung kaum mehr möglich war. Beide Geschwister und die nicht blutsverwandten Eltern des Patienten haben keinerlei auffällige Hautveränderungen. Wegweisend für die Diagnosesicherung sind Klinik und Histologie. Die elektronenmikroskopischen Befunde können wertvolle Zusatzinformationen liefern und die Diagnose bestätigen. Aufgrund einer gestörten Bildung von Bindegewebsproteinen kommt es zu Ablagerungen von Chondroitin, Kollagen und Mukopolysacchariden in den fibroblastären Zellen und im dermalen Bindegewebe. Eine wirksame Therapie der Haut- und Gelenksveränderungen existiert nicht.
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 7 (2002), S. 0 
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract Socio-demographic information was collected from 52 (45 men, seven women) currently drinking moderately dependent alcohol misusers attending an outpatient clinic in South London for medical assessment and treatment. Assessments at baseline and 12-week follow-up included: (i) Severity of Alcohol Dependence (SADQ) (baseline only), (ii) Hospital Anxiety and Depression Scale (HADS); (iii) Nottingham Health Profile sleep subscale (NHP) and (iv) the EuroQoL (EQ-5D). The main outcome measure was drinking at a “sensible level” at 12-week follow-up as recommended by the Royal College of Psychiatrists. There were significant interactions between sleeping badly, lying awake at night and HADS depression scores. The Health-related Quality of Life (HrQoL) of this group was poor compared to general population norms. Lower EQ-5D index scores were associated with poorer educational attainment and lower EQ-5D Visual Analogue Scale (VAS) patient ratings with greater baseline alcohol consumption. Clinician ratings on the EQ-5D VAS were consistently lower than the patient ratings. The correlations between patient self-assessment and clinician ratings (EQ-5D VAS) were not significant. The forty-seven subjects (90%) who were successfully followed-up showed a significant reduction in the total amount of alcohol consumed. Ten (21%) subjects returned to sensible drinking levels at 12 weeks but there was not a corresponding improvement in HrQoL, sleep, or affective status scores or biochemical measures in these subjects.
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  • 6
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A randomized, double-blind, multicentre study was performed to compare the efficacy of acitretin (50 mg/day) with hydroxychloroquine (400 mg/day) in 28 and 30 patients, respectively, suffering from cutaneous lupus erythematosus (LE). The study was carried out over an 8-week period. Improvement of facial LE lesions after treatment with acitretin and hydroxychloroquine was assessed using several clinical parameters. In the acitretin group there was marked improvement or clearing of erythema in 10/24 patients (42%), of infiltration in 15/24(63%) and of scaling/hyperkeratosis in 12/20 (60%). In the hydroxychloroquine group there was complete clearing or marked improvement of erythema in 17/25 patients (68%), of infiltration in 17/25 (68%) and of scaling/hyperkeratosis in 15/23 (65%). Overall improvement occurred in 13/28 patients (46%) treated with acitretin and in 15/30 patients (50%) with hydroxychloroquine. The incidence of side-effects was higher in the acitretin group, and necessitated discontinuation of treatment in four patients. The present results demonstrate that both acitretin and hydroxychloroquine provide effective treatment in approximately 50% of cases of cutaneous LE.
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  • 7
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background A matched case–control study was performed in Munich, Germany, in 1996–97 to evaluate the risk of cutaneous melanoma due to ultraviolet (UV) exposure behaviour in Southern Bavaria, Germany. Objectives Patients with cutaneous melanoma and controls were investigated by two physicians using a standardized questionnaire to identify risk factors for the development of melanoma, such as professional and leisure sun exposure behaviour. In each person, a total body examination was performed to detect benign skin alterations, phenotypic characteristics and precursor lesions for skin cancer. Patients/methods A total of 271 melanoma patients and 271 controls were individually matched for residence, age and gender. A multiple conditional logistic regression analysis was performed. Results Of 56 factors, those risk factors with a strong effect on the development of melanoma were: the existence of melanoma in first degree relatives, solar lentigo, actinic keratosis, actinic cheilitis, skin phototype, immediate skin reaction to UV light at the start of the outdoor season, sunburn in childhood and sun exposure during holidays in sunny areas 20 years before melanoma was diagnosed; outdoor activities in childhood were found to be protective. Conclusions Sunburn in childhood and increased sun exposure during annual holidays in sunny areas should be avoided. In contrast, outdoor activities in childhood, including soccer and gardening, should be encouraged because they are associated with a lower risk of melanoma formation.
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    British journal of dermatology 143 (2000), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Little is known about the role of mechanical trauma in the pathogenesis of malignant melanoma. In individual patients, traumatic events have been discussed as a causative factor for the induction of melanoma and diagnosis of melanoma following trauma may raise medico-legal questions. Objectives To evaluate the relationship between traumatic single or recurrent events and melanoma characteristics. Methods Retrospective questionnaire in 369 melanoma patients. Results A large number of patients (337 of 369; 91·3%) denied an association between a possible traumatic event and melanoma formation. Thirty-two of 369 patients (8·7%) considered an association of trauma and melanoma formation likely. Of these 32 patients, 22 patients (13 men, nine women) reported a single event, and 10 patients (four men, six women) a persisting irritation. An irritation of a pre-existing melanocytic naevus was reported by two patients with histologically confirmed melanoma on acquired or congenital naevus. Conclusions As most of the patients who mentioned a trauma in this study suffered from acral melanoma, or melanoma located on the extremities, a history of trauma should be expected more frequently at these body sites. A review of epidemiological, clinical and scientific research indicates that there seems to be no evidence for single or persistent traumatic events as a causative factor for melanoma formation.
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  • 9
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Reactive perforating collagenosis (RPC) is a rare skin disorder characterized by reddish papules with a central keratotic plug which appear mainly on the extensor aspects of the limbs. An idiopathic or classical variant has been delineated from an acquired one which occurs in diabetes mellitus and renal failure. Histopathological examination of the lesions shows transepidermal elimination of abnormally staining bundles of collagen. To clarify the origin of this collagenous material we performed an immunohistochemical study including biopsies of two patients with RPC, one classical and one acquired. Staining reactivity to antibodies against type IV collagen was observed, thus providing evidence that the collagen eliminated in RPC may be derived from the basement membrane zone.
    Type of Medium: Electronic Resource
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