Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    ISSN: 0168-583X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 2
    Keywords: PATHWAYS ; DISEASES ; GENE ; COMPLEX ; RESPONSES ; FAMILY ; VARIANTS ; AUTOIMMUNITY ; SCAN ; STATISTICAL-METHOD
    Abstract: To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls. We identified associations at eight previously unreported genomic loci. Seven loci harbored genes with recognized immune functions (IL28RA, REL, IFIH1, ERAP1, TRAF3IP2, NFKBIA and TYK2). These associations were replicated in 9,079 European samples (six loci with a combined P 〈 5 x 10(-)(8) and two loci with a combined P 〈 5 x 10(-)(7)). We also report compelling evidence for an interaction between the HLA-C and ERAP1 loci (combined P = 6.95 x 10(-)(6)). ERAP1 plays an important role in MHC class I peptide processing. ERAP1 variants only influenced psoriasis susceptibility in individuals carrying the HLA-C risk allele. Our findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis.
    Type of Publication: Journal article published
    PubMed ID: 20953190
    Signatur Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1741-0444
    Keywords: Radiotelemetry ; Arterial pressure ; Transmitter ; Monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Description / Table of Contents: Sommaire On a conçu un transmetteur radiotélémétrique se conformant aux normes de télémtrie biomédicale du gouvernement britannique, pour l'entegistrement soit intermittent, soit continu de la pression intra-artérielle de sujets complètement ambulants. La fréquence d'un sous-porteur de 1 kHz est modulée par l'onde de pression, la fréquence du sous-porteur est elle-même modulée à 17060 MHz sur un oscillateur controlé par cristal, et après multiplication de la fréquence, produit un signal de sortie entrainant une antenne de demionde à 102 360 MHz. L'appareil a été utilisé avec succès pour des périodes de contrôle allant de 3 à 36 h.
    Abstract: Zusammenfassung Es wurde ein Funktelemetrie-Sender, der den staatlichen britischen Vorschriften für die biomedizinische Telemetrie entspricht, für die zeitweise oder ständige Aufzeichnung des intra-arteriellen Drucks an völlig ambulanten Patienten erfunden. Durch die Druckwellenform wird die Frequenz eines Zwischenträgers von 1 kHz moduliert. Die Frequenz des Zwischenträgers wird wiederum bei 17 060 MHz zu einem quarzgesteuerten Oszillator moduliert, durch den sich nach Frequenzmultiplikation eine Leistung ergibt, die eine integrale Halbwellenantenne mit 102,360 MHz antreibt. Der Sender wurde mit Erfolg zur Überwachung von Zeiten zwischen 3 und 36 Stunden eingesetzt.
    Notes: Abstract A radiotelemetry transmitter conforming to British Governmental specifications for biomedical telemetry has been devised for either intermittent or continuous recording of intra-arterial pressure in fully ambulant subjects. A1 kHz subcarrier is frequency modulated by the pressure waveform, the subcarrier being in turn frequency modulated on to a crystal-controlled oscillator at 17·060 MHz which, after frequency multiplication, produces an output to drive an integral halfwave aerial at 102·360 MHz. The apparatus has been successfully used for monitoring for periods of 3 to 36 h.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 4
    ISSN: 1439-6327
    Keywords: Key words Peak V ; O2 ; Anaerobic performance ; Muscle volume ; Magnetic resonance imaging ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This study examined the relationships between thigh muscle volume (TMV) and aerobic and anaerobic performance in children. A total of 32 children, 16 boys and 16 girls, aged 9.9 (0.3) years completed a treadmill running test to exhaustion for the determination of peak oxygen uptake (peak V˙O2) and a Wingate Anaerobic Test (WAnT) for the determination of peak power (PP) and mean power (MP). The volume of the right thigh muscle was determined using magnetic resonance imaging. TMV was not significantly different in boys and girls [2.39 (0.29) l vs 2.18 (0.38) l, P 〉 0.05]. Peak V˙O2 and MP were significantly higher in boys than girls (P 〈 0.01) whether expressed in absolute, mass-related or allometrically scaled terms. Absolute PP was not significantly different in boys and girls but mass-related and allometrically scaled values were higher in boys (P 〈 0.01). TMV was correlated with absolute peak V˙O2, PP and MP in both sexes (r = 0.52–0.89, P 〈 0.01). In boys, mass-related PP was correlated with TMV (r =0.53, P 〈 0.01), and in girls mass-related peak V˙O2 was correlated with TMV (r = −0.61, P 〈 0.01). However, in neither sex were allometrically scaled peak V˙O2, PP or MP correlated with TMV (P 〉 0.05). There were no significant differences between boys and girls in terms of peak V˙O2, PP or MP when expressed in a ratio to TMV or allometrically scaled TMV. In conclusion, this study has demonstrated that, when body size is appropriately accounted for using allometric scaling, TMV is unrelated to indices of aerobic and anaerobic power in 10-year-old children. Furthermore, there appear to be no qualitative differences in the muscle function of boys and girls in respect of aerobic and anaerobic function.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Oxford [u.a.] : International Union of Crystallography (IUCr)
    Acta crystallographica 48 (1992), S. 519-523 
    ISSN: 1600-5759
    Source: Crystallography Journals Online : IUCR Backfile Archive 1948-2001
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 0140-1971
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine , Psychology
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1600-0625
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A C-insertion polymorphism in the NOD2 gene (3020insC) on chromosome 16 is a rare mutation associated with Crohn's disease. Crohn's disease and psoriasis are more commonly observed together than expected by chance. Furthermore a susceptibility locus for psoriasis has been identified on chromosome 16q which overlaps the recently identified susceptibility locus for Crohn's disease. Thus, NOD2 may potentially be important as a candidate susceptibility gene for psoriasis. We tested this hypothesis by genotyping psoriasis patients for the C-insertion polymorphism using the Taqman ABI 7700 sequencing system. No statistically significant differences were observed between psoriasis vulgaris (n = 216), palmo-plantar pustular psoriasis (PPP) (n = 100), guttate psoriasis (n = 118) and the control group (n = 283). In both patient and control groups, no mutant homozygotes were observed and approximately 4% were heterozygotes. This particular insertion mutation in the NOD2 gene does not appear to contribute to the genetic susceptibility of psoriasis vulgaris, PPP or guttate psoriasis. However, other mutations exist in the NOD2 gene, which may potentially have a role in psoriasis susceptibility.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 137 (1997), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Psoriasis may, in some patients, be triggered and/or exacerbated by stress.Objectives  As activation of the hypothalamic–pituitary–adrenal (HPA) axis is critical to a successful stress response we investigated this in patients with psoriasis.Methods  Forty patients with chronic plaque psoriasis and 40 age-matched normal controls experienced three randomly presented acute psychological stressors (cognitive, emotional and social). Serial serum cortisol, pulse rate and blood pressure assessments were undertaken at baseline and following each of the stressors. Salivary cortisol samples were collected at 09·00 h on the day of testing.Results  In control subjects there was a significant (r = 0·38; P 〈 0·05) correlation between pulse rate and serum cortisol level following the social performance stressor; this was not evident in the psoriasis group (r = 0·07; not significant). Patients who believed that their psoriasis was highly stress responsive had significantly lower salivary cortisol levels at baseline (P 〈 0·01) and lower serum cortisol levels following the social performance stressor (P = 0·016) than patients with nonstress-responsive disease who believed that stress had no impact. In contrast, there was no difference between the groups for change in pulse rate poststressor.Conclusions  This study shows that patients with psoriasis, and in particular those whose disease appears to be stress responsive, exhibit an altered HPA response to acute social stress. The implication is that such patients may perhaps be primed to flares of their psoriasis. Whether this is genetically predetermined and/or a consequence of the distress of living with psoriasis remains to be determined.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
  • 10
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background  Psoriasis is characterized by symmetry of plaques and modulation of multiple genes within those plaques.Objectives  We compared gene expression profiles of plaques of psoriasis at different anatomical sites for both symmetrical and asymmetrical disease to ascertain whether the same genes were expressed.Methods  Gene expression profiles were analysed in biopsies from lesional and uninvolved skin from two groups of patients with either predominantly symmetrical or truncal plaques of psoriasis vulgaris, and from normal skin of healthy volunteers. Genomic analyses were performed using cDNA array and kinetically monitored reverse transcriptase-initiated polymerase chain reaction (kRT-PCR) approaches. A cluster of genes upregulated in involved psoriasis skin as compared with normal skin was identified using each of these two technologies.Results  Clustering of patients based on their gene expression profile did not reveal any correlation with family history of psoriasis, age at onset or association of psoriasis with arthritis. There was no difference in gene expression profile between the type (symmetrical vs. truncal) or location (left vs. right side of body) of psoriatic plaques. Gene expression profiles of involved psoriatic skin analysed by kRT-PCR analysis did correlate with both global (Psoriasis Area and Severity Index) and local (erythema, desquamation and plaque elevation) clinical severity.Conclusions  These results indicate that it may be feasible to analyse the molecular effects of pharmacological agents on psoriatic skin in ‘minizone’ protocols, that the obtained data can be correlated with clinical severity and that plaques of psoriasis in the same individual express the same genes.
    Type of Medium: Electronic Resource
    Signatur Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...