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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds168 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: CANCER ; Germany ; LUNG-CANCER ; COHORT ; cohort studies ; cohort study ; RISK ; DISTINCT ; MECHANISM ; HETEROCYCLIC AMINES ; mechanisms ; DESIGN ; WOMEN ; MEN ; PROSPECTIVE COHORT ; COLORECTAL-CANCER ; COUNTRIES ; PROSTATE-CANCER ; cancer risk ; POLYCYCLIC AROMATIC-HYDROCARBONS ; Jun ; cholesterol ; DIET ; DIETARY ; CONSUMPTION ; EPIC ; GASTRIC-CANCER ; nutrition ; EUROPE ; FOOD ; DIETARY-INTAKE ; NUTRIENTS ; FRAMEWORK ; RE ; CANCER DEVELOPMENT ; PRESERVATION ; prospective ; EUROPEAN COUNTRIES ; CANCER-RISK ; N-NITROSO COMPOUNDS ; NORTHERN ; processed meat ; 24-hour dietary recall ; ANIMAL PRODUCTS ; CHOLESTEROL OXIDATION ; cooking methods ; DONE RED MEAT
    Abstract: Objective: There is increasing evidence for a significant effect of processed meat (PM) intake on cancer risk. However, refined knowledge on how components of this heterogeneous food group are associated with cancer risk is still missing. Here, actual data on the intake of PM subcategories is given; within a food-based approach we considered preservation methods, cooking methods and nutrient content for stratification, in order to address most of the aetiologically relevant hypotheses. Design and setting: Standardised computerised 24-hour diet recall interviews were collected within the framework of the European Prospective Investigation into Cancer and Nutrition (EPIC), a prospective cohort study in 27 centres across 10 European countries. Subjects: Subjects were 22 924 women and 13 031 men aged 35 - 74 years. Results: Except for the so-called 'health-conscious' cohort in the UK, energy-adjusted total PM intake ranged between 11.1 and 47.9 g day(-1) in women and 18.8 and 88.5 g day(-1) in men. Ham, salami-type sausages and heated sausages contributed most to the overall PM intake. The intake of cured (addition of nitrate/nitrite) PM was highest in the German, Dutch and northern European EPIC centres, with up to 68.8 g day(-1) in men. The same was true for smoked PM (up to 51.8 g day(-1)). However, due to the different manufacturing practice, the highest average intake of NaNO2 through PM consumption was found for the Spanish centres (5.4 mg day(-1) in men) as compared with German and British centres. Spanish centres also showed the highest intake of NaCl-rich types of PM; most cholesterol- and iron-rich PM was consumed in central and northern European centres. Possibly hazardous cooking methods were more often used for PM preparation in central and northern European centres. Conclusions: We applied a food-based categorisation of PM that addresses aetiologically relevant mechanisms for cancer development and found distinct differences in dietary intake of these categories of PM across European cohorts. This predisposes EPIC to further investigate the role of PM in cancer aetiology
    Type of Publication: Journal article published
    PubMed ID: 16870017
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  • 3
    facet.materialart.
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds345 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 4
    Keywords: MORTALITY ; HEALTH ; POPULATIONS ; CONSUMPTION ; DRINKING ; CARDIOVASCULAR-DISEASE ; METAANALYSIS ; MORBIDITY ; COMPETING RISKS ; CONFOUNDERS
    Abstract: Methods Multivariable hazard ratios were estimated for different causes of death according to patterns of lifetime alcohol consumption using a competing risks approach: 111 953 men and 268 442 women from eight countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study were included. Self-reported alcohol consumption at ages 20, 30, 40 or 50 years and at enrolment were used for the analysis; 26 411 deaths were observed during an average of 12.6 years of follow-up. Results The association between lifetime alcohol use and death from cardiovascular diseases was different from the association seen for alcohol-related cancers, digestive, respiratory, external and other causes. Heavy users (〉 5 drinks/day for men and 〉 2.5 drinks/day for women), regardless of time of cessation, had a 2- to 5-times higher risk of dying due to alcohol-related cancers, compared with subjects with lifetime light use (1 and 0.5 drink/week for men and women, respectively). Compared with lifetime light users, men who used 〈 5 drinks/day throughout their lifetime had a 24% lower cardiovascular disease mortality (95% confidence interval 2-41). The risk of death from coronary heart disease was also found to be 34-46% lower among women who were moderate to occasionally heavy alcohol users compared with light users. However, this relationship was only evident among men and women who had no chronic disease at enrolment. Conclusions Limiting alcohol use throughout life is associated with a lower risk of death, largely due to cardiovascular disease but also other causes. However, the potential health benefits of alcohol use are difficult to establish due to the possibility of selection bias and competing risks related to diseases occurring later in life.
    Type of Publication: Journal article published
    PubMed ID: 24415611
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  • 5
    facet.materialart.
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds283 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 6
    ISSN: 1432-0827
    Keywords: Key words: Ultrasound densitometry — Body composition — Fat mass — Lean body mass — Epidemiology.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Body mass is known to be related to measures of bone mineral density (BMD) as well as to parameters of quantitative ultrasound (US). To examine the effect of the body compartment's fat mass and lean body mass on quantitative ultrasonic bone parameters, data from a sample of 3241 German women were analyzed. Anthropometric measures, including skinfold thickness, were obtained from standardized measurements, and fat and lean body mass were derived from classical regression formulas based on skinfold measurements. Ultrasonic bone measurements were performed on the right os calcis, and speed of sound (SOS) and broadband ultrasound attenuation (BUA) were determined. Women were grouped into pre- and postmenopausal status; postmenopausal women were further stratified into ever and never hormone-replacement user. Correlation analysis indicated lean body mass to be stronger correlated with BUA than fat mass in both pre- (r = 0.23; P= 0.0001) and postmenopausal women with (r = 0.19; P= 0.0001) and without hormone replacement therapy (HRT) (r = 0.26; p = 0.0001). SOS demonstrated very small or no associations with body mass or its components. Multiple linear regression models were used to describe the relationship among body weight, fat mass, and lean body mass on BUA after adjustment for confounding variables. Both in pre- and postmenopausal women lean body mass was more strongly related to BUA than fat mass. However, body mass measures explained only small amounts of the overall variance in BUA (R2= 1–3% in premenopausal women; R2= 1% postmenopausal with HRT; R2= 4–5% in postmenopausal women without HRT). In conclusion, the strong influence of body mass and its components previously reported for BMD was not observed for quantitative ultrasonic bone parameters.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1436-6215
    Keywords: D2 18Omethod ; indirect calorimetry ; energy metabolism ; obesity ; D2 18O-Methode ; indirekte Kalorimetrie ; Energiemetabolismus ; Übergewicht
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Für die Bestimmung des Gesamtenergieumsatzes wurde eine neuartige2H/1H-und18O/16O-Äquilibriereinheit getestet, optimiert und eingesetzt. Es konnte gezeigt werden, daß übergewichtige Frauen und Männer, verglichen mit schlanken Probanden, sowohl erhöhte Ruhe-Nüchternumsätze, als auch erhöhte Gesamtenergieumsätze aufweisen. Der physical activity level (PAL)-Index weist tendenziell eine Verminderung auf, was eine erniedrigte physische Aktivität bei Übergewichtigen vermuten läßt.
    Notes: Summary A new2H/1H and18O/16O equilibration device was tested, standardized and employed for the determination of total energy expenditure. It was shown that overweight men and women have increased resting metabolic rate as well as increased total energy expenditure when compared to their lean counterparts. The physical activity level (PAL)index was slightly decreased which possibly suggests a decreased physical activity in obese people.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1436-6215
    Keywords: obesity ; under-reporting ; energy intake ; nutrient intake ; dietary questionnaire ; Übergewicht ; underreporting ; Energieaufnahme ; Nährstoffaufnahme ; Verzehrshäufigkeits-Fragebogen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Zusammenfassung Die Angaben zur Energie- und Nährstoffaufnahme aus einem semi-quantitativen Verzehrshäufigkeits-Fragebogen wurden auf eine mögliche Unterschätzung in Abhängigkeit vom relativen Körpergewicht untersucht. Die Studienpopulation bildeten 2 531 Personen aus Potsdam und den umliegenden Gemeinden, Männer im Alter von 40 bis 64 Jahren und Frauen im Alter von 35 bis 64 Jahren. Das Verhältnis von Energieaufnahme (EI) zu Grundumsatz (BMR) diente als Maß für die alters- und gewichtsunabhängige relative Energieaufnahme. Die Studienteilnehmer wurden auf Basis des Parameters EI/BMR in Quintile eingeteilt. Zwischen dem body mass index (BMI) und dem Parameter EI/BMR konnte, bei Männern und Frauen, ein inverses Verhältnis beobachtet werden. Zwischen verschiedenen sozio-ökonomischen Variablen und EI/BMR zeigte sich dagegen kein Zusammenhang. Während die absolute Nährstoffaufnahme mit steigendem EI/BMR zunahm, war der energieadjustierte Verzehr von Fett, Protein, Kohlenhydraten und Alkohol unabhängig von der relativen Energieaufnahme. Der Verzehr aus Lebensmittelgruppen, ebenfalls energieadjustiert, zeigte bei Frauen einen leicht ansteigenden Trend über die EI/BMR-Quintile für die Gruppen, ‚Getreide‘ und ‘Fette’ sowie einen leicht abfallenden Trend für ‚Süßigkeiten‘. Nach Zuordnung der Meßwerte in drei BMI-Kategorien, zeigte sich, daß die angegebene Energieaufnahme mit zunehmendem BMI abnahm. Der auf Basis des BMR geschätzte Energieverbrauch stieg dagegen über die BMI-Kategorien an. Es konnte ein direkter Zusammenhang zwischen der Differenz von angegebener Energieaufnahme und geschätztem Energieverbrauch und dem relativen Körpergewicht beobachtet werden. Die Ergebnisse zeigen, daß Übergewicht als ein wesentlicher Prädiktor für die Unterschätzung der Energieaufnahme gelten kann. Energieadjustierte Werte der Nährstoffaufnahme erscheinen unabhängig von dem methodischen Einfluß der Unterschätzung.
    Notes: Summary The phenomenon of underreporting of dietary intake has been observed previously in many epidemiologic studies. In this study it was investigated whether dependencies exist between energy intake obtained by a semi-quantitative, self-administered food frequency questionnaire and lifestyle or anthropometric factors, particularly obesity. The study population consisted of 2 531 subjects, men aged 40 to 64 years and women aged 35 to 64 years from the general population of Potsdam and the surrounding areas. First, subjects were allocated into quintiles of the ratio ‘reported energy intake (EI)’ to ‘calculated basal metabolic rate (BMR)’ as a measure of age and weight adjusted energy intake. No apparent dependencies between socio-economic variables and the ratio EI/BMR were observed. Among anthropometric variables, BMI and related measures of obesity were inversely related to the ratio EI/BMR in men and women. While dietary intake was directly related to the ratio EI/BMR in absolute quantities, energy adjusted intake of fat, protein, carbohydrate, and alcohol was found to be independent of this ratio. Energy adjusted food group consumption was also found to be independent of the ratio EI/BMR, showing only slightly increasing trends across quintiles of EI/BMR for cereals and fats, and a slightly decreasing trend for sweet foods in women. When subjects were classified into three categories of BMI, reported energy intake decreased across categories. Estimated energy expenditure based on BMR was increasing with BMI categories. A close direct relationship was observed between BMI categories and the difference between reported energy intake and estimated energy expenditure. It is concluded that obesity is a major determinant of underreporting. Energy adjusted dietary variables were found to be largely independent of such methodological influences.
    Type of Medium: Electronic Resource
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