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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  53. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds); 20080915-20080919; Stuttgart; DOCEPI5-2 /20080910/
    Publication Date: 2008-09-11
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds071 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 3
    Keywords: Germany ; MODEL ; MODELS ; VOLUME ; POPULATION ; RISK ; ASSOCIATION ; AGE ; WOMEN ; MEN ; smoking ; DOSE-RESPONSE ; DIETARY ; body mass index ; FOOD ; asthma ; EAST-GERMANY ; MASSES ; ADULT ; ADULTS ; RE ; SODIUM ; ECRHS ; HEALTH-SURVEY ; RESPONSIVENESS ; SALT ; european community respiratory health survey ; AIRWAY HYPERREACTIVITY ; bronchial hyperresponsiveness ; DIETARY-SODIUM ; HISTAMINE ; METHACHOLINE
    Abstract: Background: Several investigations suggested a relationship between sodium intake and asthma and bronchial hyperresponsiveness (BHR), respectively. However, clinical and epidemiological studies did not show consistent finding. Objective: We analysed the association between dietary sodium intake and BHR to methacholine among 613 adults aged 20-65 years as one of the two German centres of the European Community Respiratory Health Survey (ECRHS). Methods: Dietary sodium intake was estimated from a 3-day weighed record of food intake. We applied multiple logistic regression models contrasting the three higher quartites of sodium intake versus the lowest to assess the risk of BHR and mild BHR estimated by PD20 and PD10, respectively, controlling for potential confounders and stratified for sex. In addition, we analysed PD20 (dose of methachotine causing a fall of 20% in forced expiratory volume in 1 s) as continuous variable expressed as transformed dose-response slope (tDRS) in the linear model. Results: Women were as expected more likely to be bronchial hyperresponsive (PD2.0: 26.1%; PD10: 52.2%) than men (PD20:15.8%; PD10: 34.8%) and had a lower mean daily sodium intake (2.36 g) compared with men (3.15 g). Logistic regression did not show any significant relationship between sodium intake and BHR in terms of PD20 after adjustment for age group, education, smoking status, body mass index and height in men or women. However, mild BHR assessed as PD10 was statistically significant positively related to the third (OR: 2.35; CI: 1.11-5.00) and highest quartite of sodium intake (OR: 2.28; CI: 1.06-4.88) in women, but not in men for third quartile (OR: 1.29; Cl: 0.68-2.44) and for fourth quartile (OR: 1.07; Cl: 0.56-2.07), respectively. Conclusion: Sodium intake by several food items does not alter BHR assessed as PD20 to methacholine but may increase mild BHR assessed as PD10. We conclude that, in addition, PD10 has to be considered when the effect of sodium intake on BHR is studied. (c) 2004 Elsevier Ltd. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 15939248
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  • 4
    Keywords: Germany ; MODEL ; MODELS ; POPULATION ; METABOLISM ; BIOMARKERS ; ASSOCIATION ; ALPHA ; PLASMA ; Jun ; DIET ; DIETARY ; PREVALENCE ; nutrition ; VEGETABLES ; antioxidants ; NUTRIENTS ; ALPHA-TOCOPHEROL ; SERUM CONCENTRATIONS ; SERUM ; ADULTS ; HAY-FEVER ; REGRESSION ; RE ; allergic sensitisation ; CHILDHOOD ASTHMA ; LEVEL ; INTERVAL ; FRUITS ; fruits and vegetables ; PARTICIPANTS ; PLASMA-LEVELS ; allergic rhinitis ; EUROPEAN COUNTRIES ; odds ratio ; GAMMA-TOCOPHEROL ; ECOLOGICAL ANALYSIS
    Abstract: Objectives: Antioxidant nutrients like carotenoids, tocopherols and vitamin C have been suggested to protect against allergic rhinitis and allergic sensitisation but scientific evidence is scarce. The aims of the study were to measure the plasma concentration of six carotenoids, alpha- and gamma-tocopherol and vitamin C as biomarkers of the intake, absorption and subsequent metabolism of these nutrients, and to assess their association with allergic rhinitis and sensitisation. Method: Data from a cross-sectional study on representative dietary and lifestyle habits of the population of Bavaria, Germany, were analysed. The plasma levels of six carotenoids (alpha-carotene, P-carotene, lycopene, lutein/zeaxanthin, canthaxanthin and cryptoxanthin) as well as of alpha-tocopherol, gamma-tocopherol and vitamin C were measured in 547 adults aged between 19 and 81 years. Participants with specific serum immunoglobulin E 〉= 700 U l(-1) were categorised as sensitised. The association of plasma antioxidant levels, allergic rhinitis and allergic sensitisation was assessed by means of unconditional logistic regression models. Results: We observed a negative association between plasma total carotenoids and the prevalence of allergic rhinitis, with odds ratio (95% confidence interval) of 1.13 (0.54-2.39) for the second, 0.72 (0-33-1-58) for the third and 0.44 (0.19-1.03) for the fourth quartile of total carotenoids concentration (P for trend = 0.0332); results for lycopene failed to reach statistical significance (P = 0.0608). Other single carotenoids, tocopherols and vitamin C were unrelated to allergic rhinitis. Allergic sensitisation was negatively associated with plasma gamma-tocopherol, with odds ratio (95% confidence interval) of 0.92 (0.51-1.65) for the second, 1.00 (0-56-1.80) for the third and 0.45 (0.23-0.88) for the fourth quartile of plasma gamma-tocopherol concentration (P for trend = 0.0410). No other antioxidant was significantly related to allergic sensitisation. Conclusions: High plasma carotenoid concentrations reflecting a diet high in various fruits and vegetables might have a protective effect on allergic rhinitis in adulthood
    Type of Publication: Journal article published
    PubMed ID: 16870019
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  • 5
    Keywords: Germany ; DISEASE ; DISEASES ; METABOLISM ; MARKER ; ASSOCIATION ; ACID ; PLASMA ; AGE ; fatty acids ; DIETARY ; CHILDREN ; PREVALENCE ; ARACHIDONIC-ACID ; DIETARY-INTAKE ; asthma ; SERUM ; FATTY-ACID ; ADULT ; ADULTS ; ASSOCIATIONS ; RE ; immunoglobulin ; PHOSPHOLIPIDS ; HEALTH-SURVEY ; CHILDHOOD ASTHMA ; allergic rhinitis ; sensitisation ; ATOPIC DISEASE ; european community respiratory health survey ; LINOLEIC-ACID ; total IgE
    Abstract: The dietary intake of certain fatty acids might contribute to the development of allergic diseases such as hay fever and asthma. We investigated the association between the concentrations of fifteen fatty acids in serum phospholipids, as a marker of dietary intake and metabolism, and hay fever, allergic sensitisation and total IgE in adults. Data from a population-based cross-sectional study on respiratory health, including the measurement of fatty acids in the serum phospholipids of 740 adults between 20 and 64 years of age, were analysed. Positive associations were found between hay fever and arachidonic acid, and allergic sensitisation and oleic acid. No other fatty acids showed any association with hay fever or allergic sensitisation. Elevated levels of total IgE were not related to fatty acids. Concentrations of long-chain n-3 fatty acids, trans fatty acids or saturated fatty acids in serum phospholipids were not associated with allergic diseases in adults in this study. The present result on the association between hay fever and arachidonic acid is consistent with current hypotheses but warrants further research
    Type of Publication: Journal article published
    PubMed ID: 15946416
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  • 6
    Keywords: measurement ; Germany ; DISEASE ; DISEASES ; POPULATION ; SERA ; ASSOCIATION ; ACID ; ACIDS ; NO ; HEALTH ; AGE ; fatty acids ; FATTY-ACIDS ; DIET ; DIETARY ; sensitization ; PREVALENCE ; CONSUMPTION ; DIETARY-FAT ; DIETARY-INTAKE ; SERUM PHOSPHOLIPIDS ; asthma ; EAST-GERMANY ; SUBPOPULATION ; SERUM ; ADULT ; ADULTS ; HAY-FEVER ; PHOSPHOLIPIDS ; allergy ; allergic sensitisation ; ECRHS ; FATTY-ACID INTAKE ; hay fever ; HEALTH-SURVEY
    Abstract: The dietary intake of certain fatty acids might contribute to the development of atopic diseases Eke allergic rhinitis and asthma. We investigated the association between the ratio of n-6 and n-3 fatty acids in serum phospholipids and hay fever or allergic sensitisation in adults. Data from a population based cross-sectional study on respiratory health including measurement of fatty acids in serum phospholipids of 740 adults between 20 and 64 years of age were analysed. We could not find any significant association between n6/n3-ratio of fatty acids in serum phospholipids and hay fever or allergic sensitisation neither in the total population nor in the sub-population stratified by sex. Since no previous study on fatty acid intake confirmed the n6/n3-ratio hypothesis and this study did not find any association between the n6/n3-ratio in serum-phospholipids and hay fever or allergic sensitization, we conclude that the n6/n3-ratio hypothesis is not confirmed although biological plausible
    Type of Publication: Journal article published
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  • 7
    Keywords: Germany ; LUNG ; DISEASE ; DISEASES ; POPULATION ; IMPACT ; ASSOCIATION ; ACID ; HEALTH ; AGE ; HORMONE REPLACEMENT THERAPY ; PARAMETERS ; fatty acids ; NETHERLANDS ; DIETARY-INTAKE ; asthma ; NATIONAL-HEALTH ; SERUM ; ADULT ; ADULTS ; ECRHS ; lung function ; methods ; YOUNG-ADULTS ; bronchial hyperresponsiveness ; DOCOSAHEXAENOIC ACID ; SHORT-TERM ; PLASMA PHOSPHOLIPIDS ; ANTI-INFLAMMATION ; RESPIRATORY-HEALTH-SURVEY
    Abstract: Background The dietary intake of certain fatty acids might have an impact on inflammatory processes in the lung and therefore contribute to the development of lung diseases like asthma or COPD. Methods In this study data from a population based cross-sectional study on respirator y health including measurement of fatty acids in serum phospholipids of 593 adults between 20 and 64 years of age were analyzed. Results Statistically significant positive associations were found between percentage predicted FEV1 (P = 0.0085) and FVC (P = 0.0267) and docosahexaenoic acid concentration in serum phospholipids in men. Dihomo-gamma-linolenic acid content in serum phospholipids was significantly negatively associated with percentage predicted FEV1 (P = 0.0003) and FVC (P = 0.0045) and transformed dose-response slopes (P = 0.0488) in men. Palmitoleic acid was negatively associated with percentage predicted FEV1 (P = 0.0037) and FVC (P = 0.0029) in men. Other fatty acids in serum phospholipids did not consistently affect lung function parameters or bronchial hyperreactivity. Conclusion A high concentration of docosahexaenoic acid in serum phospholipids may have a protective effect on lung function. Because this long-chain n-3 polyunsaturated fatty acid is almost exclusively derived from marine oils, fish might have a beneficial effect on lung diseases
    Type of Publication: Journal article published
    PubMed ID: 18204906
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  • 8
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    German Medical Science; Düsseldorf, Köln
    In:  50. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie (gmds), 12. Jahrestagung der Deutschen Arbeitsgemeinschaft für Epidemiologie; 20050912-20050915; Freiburg im Breisgau; DOC05gmds061 /20050908/
    Publication Date: 2005-09-09
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 9
    Keywords: BLOOD ; Germany ; MODEL ; MODELS ; RISK ; ASSOCIATION ; ACID ; DESIGN ; MEMBRANE ; AGE ; WOMEN ; MEN ; fatty acids ; DIET ; DIETARY ; CHILDREN ; PREVALENCE ; nutrition ; DIETARY-INTAKE ; asthma ; SERUM ; FATTY-ACID ; ADULT ; ADULTS ; RE ; immunoglobulin ; SUPPLEMENTATION ; allergic sensitisation ; INTERVAL ; allergic rhinitis ; ALPHA-LINOLENIC ACID ; ATOPIC DISEASES ; dietary intake ; FISH-OIL ; IGE ; n-3 fatty acids ; red blood cell (RBC) membrane ; sensitisation ; SYMPTOMS
    Abstract: Objective: Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis. Design: Cross-sectional, population-based study. Setting: Bavarian Nutrition Survey II ( 2002 - 03), Germany. Subjects: A total of 568 adult participants, 325 women and 243 men. Methods: By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class 〉= 2), and ( ii) self-reported allergic rhinitis was examined. Results: A high cell membrane level of eicosapentaenoic acid ( EPA, 20: 5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio ( OR) and 95% confidence interval ( 95% CI) were 0.52 (0.30 - 0.90) for the highest ( vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR ( 95% CI) of 0.50 (0.24 - 1.03; P = 0.027 for trend). A higher dietary intake of alpha-linolenic acid ( ALA, 18: 3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs ( 95% CIs) of 0.51 (0.28 - 0.93) and 0.43 (0.20 - 0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y. Conclusions: In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes ( EPA) or in the diet ( ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis
    Type of Publication: Journal article published
    PubMed ID: 16015268
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