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  • 1
    Keywords: APOPTOSIS ; SURVIVAL ; Germany ; PATHWAY ; HYBRIDIZATION ; TIME ; PROGRESSION ; COMPARATIVE GENOMIC HYBRIDIZATION ; MALIGNANCIES ; meta-analysis ; ABERRATIONS ; REGIONS ; CHROMOSOMAL IMBALANCES ; GLIOMAS ; MALIGNANCY ; RE ; SOLID TUMORS ; oligodendroglioma ; 19Q ; LOSSES ; ARMS 1P
    Abstract: Many oligodendrogliomas (ODG) have been investigated by comparative genomic hybridization (CGH), To visualize characteristic aberration profiles of non-anaplastic in a comparison with anaplastic ODGs, we performed a meta-analysis of the CGH results of all 89 cases published so far. Therefore, we expanded all given aberrations to the maximum of 850 GTG band resolution. The frequencies of each chromosomal band affected by a genetic imbalance were calculated for WHO grades II and III separately. In non-anaplastic ODGs, -1p and -19q were the most prominent aberrations. In anaplastic ODGs, +7, -4q, -9p, -10, and -15q emerged additionally. We could confirm the existence of three disjunct genetically defined subgroups of ODGs, characterized by -1p/-19q (n = 58, 65%, subgroup A), +7/-10 (n = 6, 7%, subgroup B) or the absence of either of the two patterns (n = 25, 28%, subgroup C). Interestingly, we found a unique aberration pattern in subgroup C (-1p31; -4q, -11p15, -18q, -22q, +17p, + 17q) that was different from subgroups A and B, which could indicate a unique molecular carcinogenetic pathway of this ODG subset. Scrutinizing published putative progression markers of ODG, we found that only + 7, -10, and -15q significantly correlated with a higher grade of malignancy. Summing up, the expansion of the CGH results to the 850 GTG band resolution enabled a meta-analysis to visualize WHO grade-specific aberration profiles in ODG for the first time. (c) 2005 Elsevier GmbH. All rights reserved
    Type of Publication: Journal article published
    PubMed ID: 16356658
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  • 2
    Keywords: TUMOR-CELLS ; INHIBITION ; ACTIVATION ; resistance ; CANCER-CELLS ; MULTIPLE-MYELOMA ; MEDIATED APOPTOSIS ; CHEMOTHERAPEUTIC DRUGS ; HEPATOCELLULAR-CARCINOMA CELLS ; ANTICANCER THERAPY
    Abstract: A meningioma is the most common primary intracranial tumor in adults. Here, we investigated the therapeutic potential of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in 37 meningiomas. Freshly isolated primary meningioma cells were treated with TRAIL with or without different sensitizing protocols, and apoptotic cell death was then quantified. Mechanisms of TRAIL sensitization were determined by a combination of Western blotting, flow cytometry, receptor complex immunoprecipitation, and siRNA-mediated knockdown experiments. Tumor necrosis factor-related apoptosis-inducing ligand receptor expression was analyzed using immunohistochemistry and quantified by an automated software-based algorithm. Primary tumor cells from 11 (29.7%) tumor samples were sensitive to TRAIL-induced apoptosis, 12 (32.4%) were intermediate TRAIL resistant, and 14 (37.8%) were completely TRAIL resistant. We tested synergistic apoptosis-inducing cotreatment strategies and determined that only the proteasome inhibitor bortezomib potently enhanced expression of the TRAIL receptors TRAIL-R1 and/or TRAIL-R2, the formation of the TRAIL death-inducing signaling complex, and activation of caspases; this treatment resulted in sensitization of all TRAIL-resistant meningioma samples to TRAIL-induced apoptosis. Bortezomib pretreatment induced NOXA expression and downregulated c-FLIP, neither of which caused the TRAIL-sensitizing effect. Native TRAIL receptor expression could not predict primary TRAIL sensitivity. This first report on TRAIL sensitivity of primary meningioma cells demonstrates that TRAIL/bortezomib cotreatment may represent a novel therapeutic option for meningiomas.
    Type of Publication: Journal article published
    PubMed ID: 25289891
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  • 3
    ISSN: 1434-6036
    Keywords: PACS. 71.10.Pm Fermions in reduced dimensions (anyons, composite fermions, Luttinger liquid, etc.) - 73.40.Hm Quantum Hall effect (integer and fractional) - 71.27.+a Strongly correlated electron systems; heavy fermions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract: We reconsider the theory of the half-filled lowest Landau level using the Chern-Simons formulation and study the grand-canonical potential in the random-phase approximation (RPA). Calculating the unperturbed response functions for current- and charge-density exactly, without any expansion with respect to frequency or wave vector, we find that the integral for the ground-state energy converges rapidly (algebraically) at large wave vectors k, but exhibits a logarithmic divergence at small k. This divergence originates in the k-2 singularity of the Chern-Simons interaction and it is already present in lowest-order perturbation theory. A similar divergence appears in the chemical potential. Beyond the RPA, we identify diagrams for the grand-canonical potential (ladder-type, maximally crossed, or a combination of both) which diverge with powers of the logarithm. We expand our result for the RPA ground-state energy in the strength of the Coulomb interaction. The linear term is finite and its value compares well with numerical simulations of interacting electrons in the lowest Landau level.
    Type of Medium: Electronic Resource
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  • 4
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 2013-08-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tassin, Philippe -- Koschny, Thomas -- Soukoulis, Costas M -- New York, N.Y. -- Science. 2013 Aug 9;341(6146):620-1. doi: 10.1126/science.1242253.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ames Laboratory-U.S. Department of Energy and Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23929971" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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