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  • 1
    Call number: C060:84
    Keywords: Bickel, Peter J ; Mathematical Statistics
    Pages: xvii, 523 p. : ill., ports.
    ISBN: 1860946704
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    C060:84 departmental collection or stack – please contact the library
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  • 2
    Keywords: Cancer Research ; Oncology   ; Gene Expression ; Psychotherapy    ; Cancer Research ; Oncology ; Gene Expression ; Psychotherapy ; Springer eBooks
    Description / Table of Contents: Module 1. Foreword -- Module 2. Preface -- Module 3. Abbreviations -- Module 4. General introduction -- Module 5. Types of cancers -- Module 6. Cancer treatment and their side effects -- Module 7. Molecular basis of cancer -- Module 8. Ayurvedic concepts of cancer -- Module 9. Plants with anti-cancer potential -- Module 10. Psychological therapy in cancer treatment
    Abstract: This book provides detailed information on the various types of cancer, etiology, effects, and challenges associated with current cancer treatment regimes. The present edition has been written to reflect recent developments, success rates and lacunae in herbal and modern cancer therapies. It also describes the use of several herbal formulations to boost patients’ immunity, in order to prevent or help them cope with several cancers. The book highlights several herbs/shrubs/trees that have been reported to possess anti-cancer properties, paving the way for in-depth research into the dose standardization and efficacy of plant-based bioactive molecules. It also focuses on the sustainable conservation of medicinal flora, so that, in future, novel biomolecules be extracted and made available for the treatment of various cancers. Given its highly relevant content, the book will benefit the entire cancer research community (students, scientists, pharmacists, herbalists and lecturers) at universities, research institutions and industry in the areas of oncology, herbal cancer therapy, biotechnology, drug discovery, pharmaceuticals, agriculture, and various disciplines of the biomedical sciences
    Pages: XVII, 1174 p. 2847 illus., 822 illus. in color. : online resource.
    Edition: 1st ed. 2019.
    ISBN: 9789813291478
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  • 3
    Keywords: Biomedical Engineering ; Environmental management ; Soil conservation ; Microbiology ; Engineering ; Biomedical Engineering/Biotechnology ; Environmental management ; Soil Science & Conservation ; Applied Microbiology ; Nanotechnology and Microengineering ; Springer eBooks
    Description / Table of Contents: Module 1_Soil pollution: causes and consequences -- Module 2_Ex situ soil remediation strategies -- Module 3_In situ soil remediation strategies -- Module 4_Chemical methods -- Module 5_Biochar and soil remediation -- Module 6_Soil remediation through microbes -- Module 7_Soil remediation through algae, plants and animals -- Module 8_Nanobioremediation -- Module 9_Case studies and future prospects
    Abstract: This book presents a comprehensive collection of various in situ and ex-situ soil remediation regimes that employ natural or genetically modified microbes, plants, and animals for the biodegradation of toxic compounds or hazardous waste into simpler non-toxic products. These techniques are demonstrated to be functionally effective in connection with physical, chemical, and biological strategies. Soil and water contamination through heavy metals, hydrocarbons and radioactive wastes is of global concern, as these factors have cumulative effects on the environment and human health through food-chain contamination. The book discusses the utilization of algae, plants, plant-associated bacteria, fungi (endophytic or rhizospheric) and certain lower animals for the sustainable bioremediation of organic and inorganic pollutants. In addition, it explores a number of more recent techniques like biochar and biofilms for carbon sequestration, soil conditioning and remediation, and water remediation. It highlights a number of recent advances in nanobioremediation, an emerging technology based on biosynthetic nanoparticles. Lastly, it presents illustrative case studies and highlights the successful treatment of polluted soils by means of these strategies
    Pages: XVII, 240 p. 53 illus., 34 illus. in color. : online resource.
    ISBN: 9789811324208
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  • 4
    ISSN: 1615-6110
    Keywords: Angiosperms ; Plantaginaceae ; Plantago ; Breeding system ; floral features ; male and female investment ; meiotic system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Investigation of the genetic system of six species ofPlantago has revealed striking differences in their breeding and meiotic systems.Plantago patagonica is an inbreeder on account of preanthesis cleistogamy, whereasP. lanceolata is an obligate outbreeder, as it is self-incompatible.Plantago drummondii, P. lagopus, P. ovata, andP. major show mixed mating but in varying proportions. In terms of their energy budgets, outbreeding species invest more in floral advertisement and male function, while inbreeders invest more in female function. The contribution of the meiotic system to genetic variability, as revealed through recombination index, is more important in the inbreeding species.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2018-09-05
    Description: Metastasis is the primary cause of prostate cancer morbidity and mortality. Our previous studies revealed that Sam pointed domain ETS transcription factor, a.k.a. prostate-derived ETS factor (SPDEF/PDEF), inhibits prostate cancer metastasis. However, the mechanism is still unclear. In this study, using microarray and gene set enrichment analysis, we discovered that PDEF upregulated epithelial/luminal differentiation-related genes while it suppressed stemness and epithelial-to-mesenchymal transition–related genes, especially Twist1. We also observed loss of PDEF and gain of Twist1 expression during prostate cancer progression in the TRAMP mouse model. Moreover, Twist1 knockdown resulted in upregulation of PDEF expression, suggesting a reciprocal regulation between PDEF and Twist1. Mechanistically, our ChIP-seq analysis revealed that PDEF directly regulated cytokeratin 18 (CK18) transcription through the GGAT motif within its putative promoter region. CK18 knockdown resulted in increased expression of Twist1, suggesting that PDEF regulated Twist1 in part via CK18. Our analysis of multiple clinical prostate cancer cohorts revealed an inverse relationship between PDEF expression and tumor grade, tumor metastasis, and poor patient survival. Furthermore, a two-gene signature of low PDEF and high Twist1 can better predict poor survival in prostate cancer patients than either gene alone. Collectively, our findings demonstrate PDEF inhibits prostate tumor progression, in part, by directly regulating transcription of CK18, and that PDEF/Twist1 expression could help distinguish between lethal and indolent prostate cancer. Implications: This study reports the novel findings that PDEF suppresses Twist1 partly via CK18 and that PDEF/Twist1 could help distinguish between lethal and indolent prostate cancer. Visual Overview: http://mcr.aacrjournals.org/content/molcanres/16/9/1430/F1.large.jpg . Mol Cancer Res; 16(9); 1430–40. ©2018 AACR .
    Print ISSN: 1541-7786
    Electronic ISSN: 1557-3125
    Topics: Medicine
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  • 6
    Publication Date: 2018-06-02
    Description: TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in cancer cells, but not in normal cells; as such, it is a promising therapeutic agent. However, therapeutic resistance limits its clinical use in many malignancies, including prostate cancer. Strategies to sensitize cancer cells to TRAIL are urgently needed. We demonstrate here that small-molecule tetrandrine (TET) potentially sensitizes previously resistant (LNCaP and C4-2B cells) and mildly sensitive (PC3 cells) prostate cancer cells to TRAIL-induced apoptosis, and they do so by upregulating mRNA expression and protein levels of death receptors Apo Trail R1 (DR4) and Apo Trail R2 (DR5). Using shRNA knockdown, we show critical requirement of DR4 and DR5 in sensitization of prostate cancer cells to TRAIL. We show that double knockdown of DR4 and DR5 abrogated the apoptotic effects of TET and TRAIL. We also demonstrate that TET-induced DR4 and DR5 expression is independent of p53 status. Given that loss of p53 is associated with progression of prostate cancer to CRPC and NEPC, our results show that TET, by acting as a TRAIL-sensitizing agent in prostate cancer, could serve as a potential therapeutic agent in CRPC and NEPC, for which there is no cure to date. Mol Cancer Ther; 17(6); 1217–28. ©2018 AACR .
    Print ISSN: 1535-7163
    Electronic ISSN: 1538-8514
    Topics: Medicine
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  • 7
    Keywords: CANCER ; EXPRESSION ; IN-VITRO ; tumor ; AGENTS ; carcinoma ; SITES ; GENE ; GENE-EXPRESSION ; GENES ; HYBRIDIZATION ; TUMORS ; RESOLUTION ; LINES ; CANDIDATE GENE ; TARGET ; NEOPLASIA ; PROGRESSION ; AMPLIFICATION ; chromosome 2 ; COMPARATIVE GENOMIC HYBRIDIZATION ; OVARIAN-CANCER ; CHROMOSOMAL-ABERRATIONS ; MUTATION ; cervical intraepithelial neoplasia ; MUTATIONS ; SQUAMOUS-CELL CARCINOMA ; intraepithelial neoplasia ; UTERINE CERVIX ; cervical carcinoma ; gene amplification ; E7 ONCOPROTEINS ; LOH ; CGH ; CHILDHOOD NEUROBLASTOMAS ; PRECANCEROUS LESIONS ; RECURRENT PATTERN
    Abstract: We performed comparative genomic hybridization (CGH) and high- resolution deletion mapping of the long arm of chromosome 2 (2q) in invasive cervical carcinoma (CC). The CGH analyses on 52 CCs identified genetic losses at 2q33-q36, gain of 3q26-q29, and frequent chromosomal amplifications. Characterization of 2q deletions by loss of heterozygosity (LOH) in 60 primary tumors identified two sites of minimal deleted regions at 2q35-q36.1 and 2q36.3-q37.1. To delineate the stage at which these genetic alterations occur in CC progression, we analysed 33 cervical intraepithelial neoplasia (CIN) for LOH. We found that 89% of high-grade (CINII and CINIII) and 40% of low-grade (CINI) CINs exhibited LOH at 2q. To identify the target tumor suppressor gene (TSG), we performed an extensive genetic and epigenetic analyses of a number of candidate genes mapped to the deleted regions. We did not find inactivating mutations in CASP10, BARD1, XRCC5, or PPP1R7 genes mapped to the deleted regions. However, we did find evidence of downregulated gene expression in CFLAR, CASP10 and PPPIR7 in CC cell lines. We also found reactivated gene expression in CC cell lines in vitro after exposure to demethylating and histone deacetylase (HDAC) inhibiting agents. Thus, these data identify frequent chromosomal amplifications in CC, and sites of TSGs at 2q35- q36.1 and 2q36.3-q37.1 that are critical in CC development
    Type of Publication: Journal article published
    PubMed ID: 12776201
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  • 8
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A newly recorded form ofCoix with a haploid chromosome number (n=16) that is not an entire multiple of the presumed base numberx=5 andCoix aquatica (n=5) hybridize spontaneously. The hybrid plants display heterosis with regard to plant height, leaf and fruit size and anthocyanin pigmentation. All plants studied showed a total complement of 21 chromosomes. The karyotype has been classified into three size groups: long, medium and small. The chromosomes of the two parents show little homology and on the average only two bivalents are produced. Meiosis is abnormal. Only 4% viable pollen is produced and the plants are completely seedless. The production of sterile hybrids is taken to indicate a remote relationship between the genomes of the two species.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Genetica 60 (1983), S. 157-160 
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tulipa clusiana is characterized by a highly variable phenotype. The species comprises var. chrysantha Sealy (2n=2x=24), var. stellata Regel (2n=3x=36; 2n=4x=48) and var. typica Regel (2n=2x=24; 2n=4x=48; 2n=5x=60). Several populations of these varieties were all found to exhibit remarkable uniformity in basic karyotype. A few plants had some structurally altered chromosomes otherwise unknown within the species and its allies. These chromosomes are suspected to be products of translocations. They are very long with almost median centromere. Occasional aneusomaty and polysomaty have also been observed in some plants. The evolutionary significance of these aberrations is discussed.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Genetica 64 (1984), S. 135-138 
    ISSN: 1573-6857
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The paper describes the mode of origin, meiotic behaviour and phenotype of a primary trisomic (2n=12+1) of P. lagopus recovered from an experimental population of disomics. The additional chromosome advances seed germination and flowering.
    Type of Medium: Electronic Resource
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