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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  22. Jahrestagung der Retinologischen Gesellschaft; 20090626-20090627; Berlin; DOCRG2009-50 /20090629/
    Publication Date: 2009-07-07
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Retinale Angiome werden unterschieden in solche vom kapillären Typ und solche vom kavernösen Typ. Daneben ist der Typ des razemösen Angioms beschrieben worden, mit dem im allgemeinen eine arterio-venöse Malformation beim Wyburn-Mason Syndrom bezeichnet wird [2]. In dieser Übersicht werden die kapillären Angiome abgehandelt, während die kavernösen Angiome differentialdiagnostisch erwähnt werden.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1433-0415
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Die Zahl der Patienten mit Aderhautmetastasen solider Tumoren wurde in der Vergangenheit eher unterschätzt. Inzwischen ist gesichert, daß Aderhautmetastasen die häufigsten intraokulären Tumormanifestationen darstellen. Sie treten am häufigsten bei Patienten mit Bronchial- oder Mammakarzinom auf. Wegen ihrer meist zentralen Lage werden sie häufig nach einem subjektiv bemerkten Visusverlust diagnostiziert. Befinden sie sich in der peripheren Netzhaut, können sie jedoch eine beacht- liche Größe erreichen, bevor sie symptomatisch werden. Ziel der vorliegenden Arbeit ist, neben den Inzidenzen von Aderhautmetastasen, die therapeutischen Möglichkeiten – die perkutane Strahlentherapie und bei Sonderfällen auch die Chemotherapie – vorzustellen. Dabei sollen die therapeutischen Ergebnisse, die Nebenwirkungen und die Therapie des Lokalrezidivs diskutiert werden.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-2013
    Keywords: Key words Mucin secretion ; Colon cells ; HT-29/B6 cells ; Cholera toxin ; Carbachol ; Compound exocytosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Cholinergic stimulation triggers the secretion of apically stored, preformed mucin from goblet cells but the pathway of cAMP-stimulated mucin secretion is not known. In this study the effect of cholera toxin on mucin secretion in the human colonic goblet cell line HT-29/B6 was investigated and compared to the action of carbachol. PAS staining of mucin blotted onto nitrocellulose served to quantify the secretion of total mucin. Metabolic labelling was used to evaluate the secretion of newly synthesized mucin. The mucinous nature of the detected material was confirmed with an immunoblot employing a well-characterized polyclonal antibody reacting with MUC2-mucin. Cholera toxin caused a 116-fold increase of intracellular cAMP and strongly stimulated the secretion of both preformed and newly synthesized mucin for more than 20 h. Carbachol only triggered the release of preformed mucin immediately after addition. The secretory response to cholera toxin could be partly inhibited by the protein kinase A inhibitor H8 and the microtubule inhibitor colchicine. The action of carbachol was not affected by these agents. In conclusion, we demonstrate a direct cAMP-dependent effect of cholera toxin on mucin secretion by intestinal goblet cells. In contrast to carbachol, the action of cholera toxin involves de novo synthesis of mucin molecules and microtubule-mediated secretion. There seem to be distinct secretion pathways for muscarinic or cAMP-dependent stimulation of mucin secretion.
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  • 5
    ISSN: 1435-702X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Background: To evaluate the significance of angioma number (single or multiple) for the presence of von Hippel-Lindau (VHL) disease in patients presenting with capillary retinal angioma. Methods: Forty-one nonrelated patients presenting with capillary retinal angioma were evaluated. An ophthalmic workup, screening for other organ lesions, and molecular genetic screening for a mutation of the VHL gene was performed. The diagnosis of VHL was made on the basis of the personal and family history, the presence of other VHL-associated organ lesions, or the presence of a mutation of the VHL gene. Results: Thirteen patients (32%) presented with a single angioma and 28 patients (68%) presented with multiple angiomas. In 81% of all patients, VHL could be diagnosed. Diagnosis of VHL could be readily made by the personal or family history in 51% of all patients. In another 27% of all patients, VHL disease was evidenced by screening for other VHL-associated lesions. In two patients (3%) VHL could be diagnosed by molecular genetics only. All patients with multiple retinal angiomas had VHL disease and, in 38% of patients with a single angioma, VHL was present. Reasons for a missing family history in patients with VHL disease were the presence of a de novo mutation (15% of VHL patients) or clinical anticipation of VHL disease (18% of VHL patients). Conclusion: The presence of multiple retinal angiomas strongly suggests VHL disease, which, however, can be obscured by presence of a de novo mutation or by clinical anticipation of VHL disease in affected families. A single retinal angioma may be sporadic as well as the presenting sign of VHL. Diagnosis and screening for this multitumor syndrome is substantially supported by molecular genetics.
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