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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  GMS Medizinische Informatik, Biometrie und Epidemiologie; VOL: 4; DOC15 /20081028/
    Publication Date: 2008-10-29
    Description: Die Führung eines Asthma-Tagebuchs erfordert gerade von erkrankten Kindern und Jugendlichen sehr viel Disziplin. So sollen mehrmals täglich Peak-Flow-Werte mit Uhrzeit und Datum, eingenommene Medikamente und eventuell aufgetretene Beschwerden notiert werden, um den behandelnden Ärzten bessere Betreuungs- und Therapiemöglichkeiten zu bieten. In diesem Beitrag wird die Problematik erläutert und aufgezeigt, wie mit Hilfe einer mobilen Anwendung von InprimoTM versucht wird, die Compliance der jungen Patienten zu steigern und ihnen dabei zu helfen, gefährliche Asthmaanfälle zu vermeiden. Durch spezielle Funktionen werden an die anstehende Messungen erinnert und deren Einhaltung durch ein Belohnungssystem gefördert. Zudem wird die Systemstruktur dargestellt, wie etwa auf beunruhigende Verschlechterungen von Messwerten reagiert wird bzw. wie diese Trends definiert sind und erkannt werden können.
    Keywords: Mobile Computing ; Gesundheitspflege ; Tagebuch ; Asthma ; ddc: 610
    Language: German
    Type: article
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  • 2
    Keywords: APOPTOSIS ; CELLS ; IN-VITRO ; BLOOD ; CELL ; Germany ; INHIBITION ; DISEASE ; HEART ; PATIENT ; MACROPHAGES ; SERA ; treatment ; ACID ; GLUTATHIONE ; PLASMA ; DECREASE ; cholesterol ; LDL ; LIPOPROTEIN ; PERIPHERAL-BLOOD ; OXIDATION ; cysteine ; arteriosclerosis,risk factors in hyperlipidemia,glutathione in atherosclerosis,redox status as a ris ; CORONARY-ARTERY DISEASE ; HEART-DISEASE ; N-ACETYL-CYSTEINE ; SERUM LEVELS
    Abstract: Treatment of hyperlipidemic patients with the thiol compound N-acetyleysteine (NAC) was previously shown to cause a significant dose-related increase in the high-density lipoprotein (HDL) -cholesterol serum level, suggesting the possibility that its disease-related decrease may result from a diminished thiol concentration and/or thiol/disulfide redox status (REDST) in the plasma. We therefore investigated plasma thiol levels and REDST in normo-/byperlipidemic subjects with and without coronary heart disease (CHD). The thiol level, REDST, and amino acid concentrations in the plasma and intracellular REDST of peripheral blood mononuclear cells (PBMC) have been determined in 62 normo- and hyperlipidemic subjects. Thirty-three of these subjects underwent coronary angiography, because of clinical symptoms of CHD. All groups of hyperlipidemic patients under test and those normolipidemic individuals with documented coronary stenoses showed a marked decrease in plasma thiol concentrations, plasma and intracellular REDST of PBMCs, and a marked increase in plasma taurine levels. Individual plasma thiol concentrations and plasma REDST were strongly negatively correlated with the serum LDL-cholesterol and positively correlated with the serum HDL-cholesterol level. Together with the earlier report about the effect of NAC on the HDL-cholesterol serum level, our findings suggest strongly that lower HDL-cholesterol serum levels may result from a decrease in plasma thiol level and/or REDST possibly through an excessive cysteine, catabolism into taurine. (C) 2003 Elsevier Inc
    Type of Publication: Journal article published
    PubMed ID: 14607527
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  • 3
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    German Medical Science; Düsseldorf, Köln
    In:  Hypertonie 2003; 27. Wissenschaftlicher Kongress der Deutschen Hochdruckliga; 20031126-20031129; Bonn; DOC03hochV44 /20041111/
    Publication Date: 2004-11-12
    Keywords: ddc: 610
    Language: English
    Type: conferenceObject
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 125 (1949), S. 707-714 
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Zusammenfassung Röhrengalvanometer mit technischen Röhren werden theoretisch und praktisch untersucht. Entgegen den verbreiteten Ansichten lä\t sich normalerweise eine Me\grenze von 10−13 A, mit ausgewählten Röhren auch 10−14 A erreichen. Die Angaben werden an einem praktisch erprobten Gerät erläutert.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1435-1285
    Keywords: Schlüsselwörter Kosten-Effizienz – Statine – sekundäre und primäre Prävention der koronaren Herzerkrankung ; Key words Cost-effectiveness – statins – secondary and primary prevention of coronary heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In secondary prevention, statins are cost-effective and even more cost-effective than other lipid lowering drugs. Statins are especially favorable in patients with previous myocardial infarction compared to those with angina pectoris. For secondary prevention of coronary heart disease, statins should be administered generously. In primary prevention, statins are effective but not cost-efficient. Unfavorable results have to be expected especially in premenopausal women, younger patients, and in those with a low risk factor profile. For population based primary prevention, only dietary measures can be advocated; however, apart from a serious lack of compliance their efficiency has not yet been proven. Preventive measures have their own prize; in general they are considered not to prevent coronary heart disease but retard it. Therefore, such therapeutic interventions can be assumed not to reduce but rather to increase the “direct” medical costs. Furthermore, successful prevention of coronary heart disease leads, due to life-prolongation, to an increase in people out of work and in disabled patients due to age and/or disease. Therefore, an increase especially of the “indirect” costs for unemployment, pension, nursing homes, etc. must be expected.
    Notes: Zusammenfassung In der sekundären Prävention sind Statine kosteneffizient, sie sind vorteilhafter als andere Lipidsenker insbesondere bei Patienten mit durchgemachtem Herzinfart im Vgl. zu Patienten mit Angina pectoris. Statine sollten deshalb in der Sekundärprävention der koronaren Herzerkrankung großzügig verabreicht werden. Statine sind in der primären Prävention zwar wirksam, aber nicht sehr kosteneffizient. Besonders ungünstige Ergebnisse sind bei Frauen vor der Menopause, jüngeren Patienten und solchen mit einem geringen Risikoprofil zu erwarten. Für eine bevölkerungsbezogene primäre Prävention der koronaren Herzerkrankung kommt eigentlich nur eine diätetische Behandlung in Betracht, die aber eine schlechte Compliance aufweist und deren Wirksamkeit nicht hinreichend belegt ist. Da präventive Maßnahmen ihren eigenen Preis haben und den Ausbruch einer koronaren Herzerkrankung nicht verhindern dürften, dürfte eine derartige Therapie kaum eine Senkung, sondern eher eine Steigerung der “direkten”, medizinischen Kosten bedingen. Eine erfolgreiche Prävention der koronaren Herzerkrankung dürfte infolge der Lebensverlängerung wegen Alters und/oder Erkrankung zu einer Zunahme der Arbeitsunfähigen und der Behinderten führen, so daß nicht nur die “direkten” Kosten, sondern vor allem auch die “indirekten” für Renten, Sozialhilfe, Pflegeheime usw. ansteigen.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0009-3084
    Keywords: Artery wall ; Atherosclerosis ; C3H/HeJ mice ; C56BL/6 mice ; Lipoprotein retention
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Chemistry and Physics of Lipids 67-68 (1994), S. 381-385 
    ISSN: 0009-3084
    Keywords: Lp(a) and thrombolysis ; Myocardial infarction ; Plasminogen
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1440
    Keywords: Monocyte ; Adhesion ; Protein kinase C ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The accumulation of blood monocytes at sites of predilection of the vessel wall is an early cellular event of atherogenesis. Proteins of the vessel wall may facilitate monocyte adhesion and thus promote their recruitment. It has been shown that the relative content of extracellular fibrinogen increases during lesion development, and this study investigated the contribution of immobilized fibrinogen to monocyte adhesion and the underlying mechanism. Freshly isolated human blood monocytes were cultivated in serum-free RPMI 1640 in tissue culture wells precoated with albumin, fibrinogen, or fibrin. After 16 h the plates were washed and adherent cells enumcrated. Immobilized fibrinogen enhanced monocyte adhesion more than 1.9-fold compared to immobilized albumin or fibrin (P〈0.05). Concomitant addition of the protein kinase C (PKC) inhibitors staurosporine or H7 suppressed monocyte adherence to immobilized fibrinogen but exerted no significant effect upon adhesion to any other surface tested. Stimulation of monocytes using phorbol myristate acetate resulted in increased binding of monocytes on fibrinogen but not on bovine serum albumin. When PKC activity was reduced through prolonged incubation with PMA for 16h, a significant reduction of monocyte adhesion on fibrinogen was observed. Peptides containing RGD sequences, which have been demonstrated to be ligands for certain integrins, did not inhibit monocyte adhesion. The data suggest that fibrinogen promotes monocyte adhesion in vitro by a PKC-dependent mechanism. PKC appears to be important not only for the initial cell adhesion but also for sustained binding of monocytes to fibrinogen.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1440
    Keywords: Key words Monocyte ; Adhesion ; Protein kinase C ; Atherosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The accumulation of blood monocytes at sites of predilection of the vessel wall is an early cellular event of atherogenesis. Proteins of the vessel wall may facilitate monocyte adhesion and thus promote their recruitment. It has been shown that the relative content of extracellular fibrinogen increases during lesion development, and this study investigated the contribution of immobilized fibrinogen to monocyte adhesion and the underlying mechanism. Freshly isolated human blood monocytes were cultivated in serum-free RPMI 1640 in tissue culture wells precoated with albumin, fibrinogen, or fibrin. After 16 h the plates were washed and adherent cells enumerated. Immobilized fibrinogen enhanced monocyte adhesion more than 1.9-fold compared to immobilized albumin or fibrin (P〈0.05). Concomitant addition of the protein kinase C (PKC) inhibitors staurosporine or H7 suppressed monocyte adherence to immobilized fibrinogen but exerted no significant effect upon adhesion to any other surface tested. Stimulation of monocytes using phorbol myristate acetate resulted in increased binding of monocytes on fibrinogen but not on bovine serum albumin. When PKC activity was reduced through prolonged incubation with PMA for 16 h, a significant reduction of monocyte adhesion on fibrinogen was observed. Peptides containing RGD sequences, which have been demonstrated to be ligands for certain integrins, did not inhibit monocyte adhesion. The data suggest that fibrinogen promotes monocyte adhesion in vitro by a PKC-dependent mechanism. PKC appears to be important not only for the initial cell adhesion but also for sustained binding of monocytes to fibrinogen.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1440
    Keywords: Gene therapy ; Vascular gene transfer ; Vessel wall ; Smooth muscle cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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