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  • 1
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCPO12-1071 /20131023/
    Publication Date: 2013-10-24
    Keywords: MALDI MS ; Arthritis ; m/z ; FFPE ; ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCPO23-1214 /20131023/
    Publication Date: 2013-10-24
    Keywords: MALDI MS ; Meniskusdegeneration ; m/z ; FFPE ; ddc: 610
    Language: German
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  • 3
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCPO18-534 /20131023/
    Publication Date: 2013-10-24
    Keywords: ddc: 610
    Language: German
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  • 4
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    German Medical Science GMS Publishing House; Düsseldorf
    In:  Deutscher Kongress für Orthopädie und Unfallchirurgie (DKOU 2013); 20131022-20131025; Berlin; DOCPO12-425 /20131023/
    Publication Date: 2013-10-24
    Keywords: Rheumatoide Arthritis ; Molekularpathologie ; Micro-RNA ; Osteoarthritis ; Histopathologie ; ddc: 610
    Language: German
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  • 5
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Long-term treatment with natural and synthetic thymic and splenic peptides as well as cyclosporin A inhibited the development of antigen-induced arthritis in rats. This was demonstrated by decreased joint swelling and reduced degree of macroscopically and histologically evaluated severity of synovitis. The drug treatment also decreased serum levels of antibodies against the specific antigen methylated bovine serum albumin (mBSA) and against cartilage proteoglycans and collagens type I and II. The conclusion from these studies is that the treatment with immunomodulatory thymic and splenic peptides and with the T-cell-directed immunosuppressive drug cyclosporin A inhibits the specific immune response against mBSA and/or the development of autoimmunity against cartilage constituents. The decreased immune reactivity in the joint may reduces the severity of chronic joint inflammation.
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  • 6
    ISSN: 1573-6865
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary An improved technique is described that addresses the problems of sensitivity, specificity, the use of hazardous radioactive equipment and time consumption in immunohistochemical labelling and double labelling ofin situ hybridization of tissue specimens. It consists of a two-step protocol in which digoxigenin-uridine triphosphate (UTP) labelled riboprobes in thein situ hybridization step are visualized by the immunogold-silver staining method, and double labelling of tissue antigens is achieved by the application of an alkaline phosphatase-anti-alkaline phosphatase staining step. We tested this protocol using snap-frozen tissue sections of synovial tissue from patients with rheumatoid arthritis. The target mRNA was detected by perforin or cathepsin D riboprobes, the double labelling was performed using anti-collagen type IV and alpha-smooth muscle actin antibodies. It is concluded that, in comparison with an established three-to four-day double-labelling protocol used in many laboratories, this one-day combination is currently the most rapid assay of reliable quality for double labelling ofin situ hybridization products and tissue antigens.
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  • 7
    ISSN: 1432-1963
    Keywords: Schlüsselwörter Thymom ; Hamartom ; Weichteilgewebe ; Immunhistochemie ; Key words Thymoma ; Hamartoma ; Soft tissue ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary We report the case of an ectopic hamartomatous thymoma in a 56-year-old male patient. The lesion arose subcutaneously in the supraclavicular region. Histologically, the well-circumscribed but unencapsulated tumour was composed of uniform fusiform tumour cells. In addition, mature fatty tissue, scattered T-lymphocytes, and an epithelial and a myoepithelial tumour cell component were found. The epithelial differentiation of the spindle cell tumour component was confirmed immunohistochemically and by electron microscopy. Ectopic hamartomatous thymoma has to be distinguished from ectopic cervical thymoma, thymolipoma, ectopic salivary tissue, teratoma, peripheral nerve sheath tumours, malignant epithelial tumours with thymus-like differentiation, biphasic synovial sarcoma, and skin adnexal tumours.
    Notes: Zusammenfassung Vorgestellt wird der Fall eines ektopischen hamartomatösen Thymoms bei einem 56 jährigen männlichen Patienten. Der subkutan gelegene, gut umschriebene, jedoch nicht gekapselte Tumor war supraklavikulär lokalisiert und aus relativ uniformen, spindeligen Tumorzellen aufgebaut. Zusätzlich fanden sich reife Fettgewebsinseln, eingestreute T-Lymphozyten sowie eine epitheliale und eine myoepitheliale Tumorzellkomponente. Sowohl immunhistologisch als auch ultrastrukturell konnte die epitheliale Differenzierung der spindeligen Tumorzellen nachgewiesen werden. Differentialdiagnostisch muß das ektopische hamartomatöse Thymom gegenüber ektopischen zervikalen Thymomen, Thymolipomen, ektopischem Speicheldrüsengewebe, Teratomen, peripheren Nervenscheidentumoren, malignen epithelialen Tumoren mit einer thymusähnlichen Differenzierung, biphasischen Synovialsarkomen und Tumoren der Hautadnexe abgegrenzt werden.
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  • 8
    ISSN: 1433-0385
    Keywords: Key words: Pulmonary artery sarcoma ; Intimal sarcoma ; Surgical therapy ; Pulmonary artery obstruction ; Pulmonary thromboendarterectomy. ; Schlüsselwörter: Pulmonalissarkom ; intimales Sarkom ; chirurgische Therapie ; Pulmonalarterienverschluß ; pulmonale Thrombendarteriektomie.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Unter den ohnehin seltenen Malignomen der großen Gefäße stellen die intimalen Sarkome der Pulmonalarterie eine Rarität dar. Trotz systematischer Diagnostik ist die Unterscheidung zwischen Lungenembolie und Tumor kaum möglich. Berichtet wird von einem Patienten mit linksseitigem Pulmonalarterienverschluß, bei dem präoperativ ein maligner Tumor nicht ausgeschlossen werden konnte. Der operative Eingriff wurde als Pulmonalisthrombendarteriektomie begonnen, die Schnellschnittuntersuchung wies den mesenchymalen Tumor nach, so daß eine Pneumonektomie unter Einsatz der Herz-Lungen-Maschine mit Pulmonalisrekonstruktion durchgeführt wurde. Eine kontralaterale Solitärmetastase wurde 3 Monate später mittels Keilresektion entfernt. Die Resektion ist die derzeit einzige erfolgversprechende Therapie des Pulmonalarteriensarkoms. Allerdings sind diese Operationen sehr ausgedehnt und erfordern, da differentialdiagnostisch chronische Lungenembolien schwer auszuschließen sind, Erfahrung mit dem ganzen Spektrum der Pulmonalarterienchirurgie.
    Notes: Summary. Intimal sarcoma of the pulmonary artery is an extremely rare type of malignant tumor of the large vessels. Despite systematic diagnostics, distinguishing between pulmonary emboli and tumors is difficult. We report a patient who was referred because of suspected embolic occlusion of the pulmonary artery. The operation was started with the intention of performing a pulmonary artery thromboendarterectomy; however, intraoperative histology revealed a malignant mesenchymal tumor. Therefore, the left lung was resected with the use of extracorporeal circulation, and the pulmonary trunk and right pulmonary artery were reconstructed. A solitary right lung metastasis was resected 3 months later using stapling devices. Complete surgical resection is the treatment of choice for patients with sarcoma of the pulmonary arteries. Surgical therapy often includes extensive reconstructive measures. Since, thromboembolic obstruction cannot be excluded preoperatively, patients with this type of disease should be treated at centers experienced with the broad spectrum of pulmonary artery surgery.
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  • 9
    ISSN: 1434-3940
    Keywords: Schlüsselwörter Odontogene Zyste ; Laterale parodontale Zyste ; Botryoide odontogene Zyste ; Kieferzyste ; Zytokeratine ; Keywords Odontogenic cyst ; Lateral periodontal cyst ; Botryoid odontogenic cyst ; Jaw cyst ; Cytokeratins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract The botryoid odontogenic cyst (BOC) is considered a rare multilocular variant of the lateral periodontal cyst. The origin of the BOC can be seen in aberrant odontogenic tissue. The BOC is found especially in the premolar region of the mandible, as well as in the frontal region of the maxilla of patients aged between 60 and 70 years. Most of the 11 published articles of BOC have shown high rates of recurrence. Histopathologically the BOC is marked by multilocular cysts lined by a thin, nonkeratinized epithelium. Clusters of glycogen-rich epithelial cells may be noted in nodular thickenings of the cyst lining. For the clinician, the differentiation of the BOC from the keratocyst and ameloblastoma is ¶relevant. One case of a large BOC (65-year-old male, BOC regio 33–45, diameter 5 cm, radiographically and histologically multilocular) is presented with a review of the literature, including the therapeutic management, and the possible diagnostic criteria are discussed. The immunohistochemically determined expression of cytokeratin (CK) 13 implicates the histogenetic origin of the BOC from the squamous epithelium of the oral cavity and excludes the origin from the small salivary glands. The expression of CK 19 and the lack of expression of p53, as well as the higher proliferation rate of the basal epithelial cell layer by the BOC, may be useful for distinction between the keratocyst.
    Notes: Zusammenfassung Die botryoide odontogene Zyste (BOC) ist eine seltene multilokuläre Variante der lateralen parodontalen Zyste. Sie entsteht aus versprengten odontogenen Zellanteilen. Die BOC tritt besonders häufig im Prämolarenbereich des Unterkiefers und im anterioren Oberkiefer bei Patienten zwischen der 6. und 7. Lebensdekade auf. Unter den bisher publizierten 11 Arbeiten zeigt sich eine hohe Rezidivhäufigkeit. Histologisch ist die BOC durch multilokuläre Zysten mit einem isomorphen Epithel gekennzeichnet. Dieses zeigt fokale plaqueähnliche Verdickungen durch Gruppierungen glykogenreicher Plattenepithelzellen. Für den Kliniker ist die Abgrenzung zur Keratozyste bzw. zum Ameloblastom differentialdiagnostisch bedeutsam. Ein Zufallsbefund einer besonders großen BOC (65 Jahre, männlich, BOC-Regio 33–45, 5 cm Durchmesser, radiologisch und histologisch multilokulär) wird inklusive therapeutischem Vorgehen und Literaturübersicht vorgestellt, mögliche Diagnosekriterien werden diskutiert. Der immunhistochemische Nachweis der Expression von CK13 impliziert eine histogenetische Ableitung der BOC vom oralen Plattenepithel und spricht gegen eine Ableitung von den Speicheldrüsen. Die Expression von CK19 und die fehlende Expression des p53 sowie die hohe Proliferation in der Basalzellschicht durch die BOC können zur Abgrenzung von der Keratozyste benutzt werden.
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  • 10
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Progress in biocompatibility and tissue engineering would today be inconceivable without the aid of in vitro techniques. Endothelial cell cultures represent a valuable tool not just in haemocompatibility testing, but also in the concept of designing hybrid organs. In the past endothelial cells (EC) have frequently been used in cytotoxicity testing of materials, especially polymers, used in blood-contacting implants, as well as for investigating seeding technologies for vascular prostheses. At present the exponential development both in theory and practice of cell and molecular biology of the endothelium offers great promise in the biomaterial field. Up until now this EC research field has mostly been non-biomaterial orientated. Nevertheless, the relevance for biomaterial research is apparent. Four aspects will be concisely reviewed under the headings inflammation, with special reference to cell adhesion molecules (CAMs) and cytokines, angiogenesis, focusing on the healing response, signal transduction, presenting examples from cytokine- and metal ion-induced up-regulation of genes coding for CAMs, and, finally, endothelial functionality, with emphasis on the principal characteristics of the physiological endothelial phenotype. Finally, the application of these fields to three foci of biomaterial research will be discussed, emphasizing the role of EC culture techniques in controlling the host response to biomaterials (microvascular EC), controlling EC functionality (promoting positive effects and down-regulating negative effects), and tissue engineering (integration of EC into hybrid organs/biosensors). The need for more co-culture and three-dimensional models will be stressed and data from the authors’ laboratory presented to illustrate these principles. © 1999 Kluwer Academic Publishers
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