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  • 1
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    German Medical Science; Düsseldorf, Köln
    In:  123. Kongress der Deutschen Gesellschaft für Chirurgie; 20060502-20060505; Berlin; DOC06dgch5490 /20060502/
    Publication Date: 2006-05-09
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 2
    Keywords: ENVIRONMENT ; CANCER ; GROWTH ; IN-VITRO ; tumor ; carcinoma ; IN-VIVO ; MODEL ; tumor growth ; SURGERY ; AIR ; animals ; BODY-WEIGHT ; METASTASIS ; IMPLANTATION ; PRESSURE ; CARBON-DIOXIDE ; helium ; INSUFFLATION ; laparoscopy ; RANDOMIZED TRIAL ; experimental studies ; experimental study ; hepatectomy ; insufflation gas
    Abstract: Background: After exposure of neoplastic tissue to helium, a significant reduction of tumor growth has been detected in experimental studies, both in vitro and in vivo. This tumor- suppressive effect of helium is controversly discussed in the literature. It was therefore the aim of this study to investigate the influence of pneumoperitoneum with CO2, room air, or helium in a tumor-bearing small animal model comparing laparoscopic partial hepatic resection for hepatocellular carcinoma with conventional open partial hepatectomy. Methods: One-hundred forty-eight male American Cancer Institute rats underwent partial hepatectomy for curative resection of previously induced hepatocellular carcinoma (Morris hepatoma 3924A). Resection was performed either in open laparotomy (n = 30) or laparoscopically under the employment of CO2 (n = 30), room air (n = 30), or helium (n = 30) for the pneumoperitoneum. Twenty-eight animals served as controls receiving anesthesia but no tumor resection. All animals were sacrificed on postoperative days 21, 35, or 56 for autopsy and evaluation of possible tumor recurrence and metastasis. Results: Significant reduction of postoperative tumor recurrence and metastasis was observed in the group of animals receiving laparoscopic tumor resection under helium insufflation compared to open surgery or laparoscopic resection with air pneumoperitoneum. Conclusions: The results of this study suggest a suppressive effect of helium pneumoperitoneum on postoperative tumor growth and metastatic spread. Furthermore, tumor exposure to room air appears to have a stimulative influence on tumor recurrence and metastasis compared to a pneumoperitoneum established with CO2
    Type of Publication: Journal article published
    PubMed ID: 12632132
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  • 3
    Keywords: CELLS ; GROWTH ; tumor ; Germany ; INHIBITION ; MICROSCOPY ; VOLUME ; liver ; SURGERY ; ACTIVATION ; MICROCIRCULATION ; RAT ; RATS ; SUPPRESSION ; IMPLANTATION ; EMBOLISM ; helium ; INSUFFLATION ; laparoscopy ; LIVER-CANCER ; TUMOR-GROWTH ; interaction ; PNEUMOPERITONEUM ; ANIMAL-MODEL ; histo morphology tumor volume ; intravital microscopy
    Abstract: Background: Previouse studies indicate that helium pneumoperitoneum used for laparoscopic surgery suppresses whereas carbon dioxide pneumoperitoneum increases postoperative tumor growth. The pathomechanisms of decreased tumor growth by helium are unknown. This study was designed to examine the effect of the Lyases helium. carbon dioxide (CO2), and air, and xenon, which can be used to induce pneumoperitoneum in laparoscopy on tumor volume, histomorphology, and leukocyte-endothelium interaction measured by intravital microscopy in rats with implanted liver malignoma (Morris hepatoma 3924A). Methods: In 46 rats, Morris hepatoma 3294A cells were implanted intrahepatically. After implantation, rats were randomized into two main groups. In the first main group, 10 animals were prepared for examination of leukocyte-endothelium interaction by intravital video microscopy and were randomized into two groups. Five days after implantation they underwent laparoscopy using either helium (n = 5) or CO2 (n = 5). Ten days after implantation the rats underwent intravital video microscopy to assess leukocyte-endothelium interaction in the tumor and liver vessels. In the second main group 36 rats were prepared for examination of tumor volume arid histomorphology. They were randomized into five groups. Five days after implantation they underwent laparoscopy using helium (n 7), carbon dioxide (n = 7), room air (n = 7), or xenon (n = 8). The control group (n = 7) received anesthesia only. Rats were killed 10 days after tumor implantation to assess tumor volume and histomorphology. Results: Compared to the control group or groups that received CO2, room air, or xenon for pneumoperitoneum, the establishment of helium pneumoperitoneum caused a significantly smaller tumor volume (Kruskal-Wallis test, p = 0.001; median tumor-volume: control group, 44 mm(3); helium 19 mm(3)). There was no significant difference in histomorphology between the groups. There was only a statistically significant difference in the development of central tumor necrosis in accordance to tumor volume (Mann-Whitney test, p = 0.03). In the tumor samples, roller counts were statistically significantly higher in the helium group compared to the CO2 group (p = 0.04). For sticker counts, no statistically significant effects due to liver/tumor (p = 0.13) or treatment (p = 0.48) were observed. Conclusions: There was a significant decrease in tumor volume using helium pneumoperitoneum for laparoscopy compared to the other gases. Here, we demonstrate that suppression Of tumor growth is not due to variation of histomorphology. It seems that helium pneumoperitoneum effects a higher leukocyte-endothelium interaction and thereby a higher immune activation. This could be one explanation for the statistically significantly smaller tumor volume after laparoscopy with helium compared to laparoscopy with CO2
    Type of Publication: Journal article published
    PubMed ID: 15529193
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  • 4
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    German Medical Science; Düsseldorf, Köln
    In:  121. Kongress der Deutschen Gesellschaft für Chirurgie; 20040427-20040430; Berlin; DOC04dgch0946 /20041007/
    Publication Date: 2004-10-07
    Keywords: ddc: 610
    Language: German
    Type: conferenceObject
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  • 5
    Keywords: ENVIRONMENT ; APOPTOSIS ; CELLS ; GROWTH ; proliferation ; tumor ; CELL ; CELL-PROLIFERATION ; Germany ; MODEL ; tumor growth ; VOLUME ; liver ; NEW-YORK ; SURGERY ; AIR ; RAT ; RATS ; DIFFERENCE ; DECREASE ; IMPLANTATION ; HEPATOMA ; CARBON-DIOXIDE ; EMBOLISM ; helium ; INSUFFLATION ; laparoscopy ; laparoscopy,pneumoperitoneum,helium,tumor volume,proliferation,apoptosis
    Abstract: Background: Previous reports suggest that helium pneumoperitoneum used for laparoscopic surgery suppresses postoperative tumor growth. The present study was designed to determine the effects of gases used in laparoscopy on tumor volume, proliferation, and apoptosis in rats with implanted malignoma.Methods: In 36 rats Morris hepatoma 3294A cells were implanted intrahepatically. Then, after 5 days, they underwent laparoscopy using helium (n = 7), CO2 (n = 7), room air (n = 7), or xenon (n 8). One group received anesthesia only (n = 7). Rats were killed 10 days after implantation to assess tumor volume, proliferation, and apoptosis.Results: Helium pneumoperitoneum caused a significant smaller tumor volume compared to other groups (Kruskal-Wallis test: p - 0.001; median tumor volume: control: 44 mm(3); helium: 19 mm(3)). There was no significant difference in tumor cell proliferation (PCNA) and apoptosis (TUNEL reaction) between the groups.Conclusions: There was a significant decrease of tumor volume using helium pneumoperitoneum compared to the other gases, but no decreased tumor cell proliferation or increased tumor cell apoptosis
    Type of Publication: Journal article published
    PubMed ID: 12915966
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Molecular and Cellular Endocrinology 29 (1983), S. 349-362 
    ISSN: 0303-7207
    Keywords: androgens ; exchange assay ; lamb ; nuclei
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0303-7207
    Keywords: androgen-binding protein (ABP) ; ram ; receptor ; testis ; testosterone
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 0739-7240
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1433-0385
    Keywords: Key words: Endorectal ultrasound ; Rectal carcinoma ; Preoperative radio(chemo)therapy. ; Schlüsselwörter: Endorectaler Ultraschall ; Rectumcarcinom ; präoperative Radio(Chemo)therapie.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. Die endorectale Sonographie hat eine wesentliche Bedeutung für die Indikation zur präoperativen Radio(Chemo)therapie des ausgedehnten Rectumcarinoms. Die präoperative Radio(Chemo)therapie führt in 73,5 % zu einer vermehrten Echogenität des Ultraschallbildes. Dies entspricht histologisch einer vermehrten Fibrosierung. Trotzdem läßt sich die lokale Tumorinfiltrationstiefe (T) und der Lymphknotenstatus (N) nach präoperativer Radio(Chemo)therapie mit einer Genauigkeit von 75 % im Vergleich mit der postoperativen Histologie vorhersagen. Durch die endorectale Sonographie vor und nach präoperativer Radio(Chemo)therapie (n = 28 Patienten) ließ sich endosonographisch 10 × ein „downstaging“ beobachten (3 × bzgl. T und 7 × bzgl. N-Kategorie) und 3 × ein „upstaging (3 × bzgl. T und einmal bzgl. N-Kategorie). Eine endosonographische Unterschätzung der lokalen Tumorinfiltrationstiefe nach präoperativer Radio(Chemo)therapie erfolgte nicht.
    Notes: Summary. Endorectal ultrasound (EUS) is important for the indication of preoperative radio(chemo)therapy of locally advanced rectal carcinomas. Preoperative radio(chemo)therapy causes an increased echogenity of the ultrasound, which histologically corresponds with increased fibrosis. After preoperative radio(chemo)therapy, the accuracy rate for EUS of tumor infiltration depth (T) and lymph-node status (N) is 75 % compared with postoperative histology. With the help of EUS before and after radio(chemo)therapy (n = 28 patients) „downstaging“ was noticed endosonographically in 10 patients (3 times in T and 7 times in N staging) and „upstaging“ in 3 patients (3 times in T and 1 times in N staging). There was no„understaging“ of local tumor infiltration depth after preoperative radio(chemo)therapy.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1433-0385
    Keywords: Key words: Endosonography ; Hydrosonography ; Gastric cancer ; Preoperative staging. ; Schlüsselwörter: Endosonographie ; Hydrosonographie ; Magencarcinom ; präoperatives Staging.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung. In einer prospektiven Untersuchung wird die transabdominelle Sonographie in Hydrotechnik (Hydrosonographie) mit der Endosonographie zum locoregionären Staging des Adenocarcinoms des Magens verglichen. Dazu wurden 52 konsekutive Patienten sowohl endosonographisch (7,5 und 12 MHz) als auch hydrosonographisch (3,75 MHz) untersucht. 49 der 52 Tumoren konnten endosonographisch, 41 hydrosonographisch untersucht werden. Die Genauigkeit der Endosonographie zur T-Klassifizierung betrug 74 %, die der Hydrosonographie 46 %. Kardiacarcinome wurden oft aufgrund des subserösen Fettgewebes präoperativ als uT3 oder hT3, postoperativ als pT2 klassifiziert. Die Genauigkeit der Endosonographie in der Lymphknotendiagnostik betrug 86 %, die der Hydrosonographie 61 %. Aufgrund dieser Ergebnisse kann die transabdominelle Sonographie in Hydrotechnik die Endosonographie nicht ersetzen. Die Hydrosonographie kann jedoch im Rahmen der allgemeinen abdominellen Sonographie eine Erweiterung der orientierenden Untersuchung darstellen und in besonderen Fällen (z. B. stenosierende Tumoren) kann sie ohne Strahlenbelastung wichtige Informationen über das lokale Tumorstadium liefern.
    Notes: Summary. Transabdominal ultrasound in the hydrotechnique (hydrosonography) was compared with endosonography for the locoregional staging of gastric cancer. For this purpose 52 consecutive patients were examined by endosonography (7.5 and 12 MHz) and hydrosonography (3.75 MHz). Forty-nine of the 52 tumors could be examined by endosonography and 41 by hydrosonography. The T-staging accuracy rate of endosonography was 74 % and 46 % for hydrosonography. Carcinoma of the cardia are often classified as uT3 and hT3 preoperatively and pT2 postoperatively due to infiltration of the subserosal fat. The N-staging accuracy rate of endosonography was 86 % and 61 % for hydrosonography. Based on these results, transabdominal ultrasound in the hydrotechnique (hydrosonography) cannot replace endosonography in gastric cancer staging. However, when performed in conjunction with conventional ultrasound, hydrosonography provides useful information about the local tumor stage, especially in cases of advanced and stenotic tumors.
    Type of Medium: Electronic Resource
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